856307-27-2_化工百科

中文名	安乃近杂质C(EP)
英文名	4-Methylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one Hydrochloride (4-Methylaminophenazone Hydrochloride)
别名	安乃近杂质C 安乃近杂质C(EP) 安乃近EP杂质C盐酸盐安乃近杂质C(EP) 4-甲氨基安替比林盐酸盐安乃近EP杂质C HCL 安乃近杂质C(EP) 标准品 N-甲基-4-氨基安替比林盐酸盐
英文别名	Metamizole EP Impurity C Metamizole EP Impurity C HCl 4-Methylamino-1,5-dimethyl-2-phenyl 4-Methylaminoantipyrine hydrochloride 4-METHYLAMINOANTIPYRINE HYDROCHLORIDE N-Methyl-4-aminoantipyrine Hydrochloride MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-, hydrochloride 4-Methylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one Hydrochloride (4-Methylaminophenazone Hydrochloride)
CAS	856307-27-2
化学式	C12H16ClN3O
分子量	253.73
熔点	>195°C
溶解度	氯仿 (微溶，超声处理)，DMSO (微溶)，水 (微溶)
存储条件	Hygroscopic, -20°C Freezer, Under inert atmosphere
稳定性	吸湿性
外观	固体
颜色	Pale Orange to Light Brown
体外研究	Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important.
体内研究	The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine.

湖北扬信医药科技有限公司

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产品名: 安乃近杂质3 盐酸盐（安乃近EP杂质C 盐酸盐）去供应商网站查看询盘
CAS: 856307-27-2
产地: 中国-STD
包装: 支
规格: 10mg，25mg，50mg，100mg
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上海麦克林生化科技股份有限公司

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产品名: 1,5-dimethyl-4-(methylamino)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride 去供应商网站查看询盘
CAS: 856307-27-2
产地: 上海
规格: M937652
价格: 25mg-1134,50mg-1674,100mg-2646
库存: 15天内发货
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