85858-76-0
FK-448 Free base(FK-448 Free base)
CAS: 85858-76-0
化学式: C25H30N2O3
| 中文名 | FK-448 Free base |
| 英文名 | FK-448 Free base |
| 别名 | 化合物 T11290 |
| 英文别名 | FK-448 Free base 1-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-, 4-[[4-(1-methylethyl)-1-piperazinyl]carbonyl]phenyl ester |
| CAS | 85858-76-0 |
| 化学式 | C25H30N2O3 |
| 分子量 | 406.52 |
| 存储条件 | 2-8℃ |
| 体外研究 | FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC 50 of 720 nM. FK-448 Free base slightly inhibits esterolysis of Trypsin and Thrombin, with IC 50 s of 780 and 35 μM, respectively, but shows no effects on esterolysis of plasmin, plasma kallikrein or pancreas kallikrein, with IC 50 s of all >1 mM. FK-448 moderately inhibits hydrolytic activities of cathepsin G with an IC 50 of 15 μM. |
| 体内研究 | FK-448 (20 mg/kg, i.p.) results in a decrease in the blood glucose level, and inhibits the degradation of insulin by pancreatic enzymes in rats. FK-448 (20 mg/kg, p.o.) also decreases the blood glucose level, and increases plasma IRI level in dogs. |
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现货供应
产品名: FK-448 Free base 去供应商网站查看 询盘CAS: 85858-76-0
产地: 上海
规格: F876974
价格: 5mg-6861,1mg-3431
库存: 15天内发货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
现货供应
产品名: FK-448 Free base 去供应商网站查看 询盘CAS: 85858-76-0
产地: 上海
规格: F876974
价格: 5mg-6861,1mg-3431
库存: 15天内发货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191
微信: 19863730987/13918391375
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