中文名 | Merafloxacin |
英文名 | 1-Ethyl-7-(3-((ethylamino)methyl)pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
别名 | 化合物MERAFLOXACIN 3-喹啉羧酸,1-乙基-7-[3-[((乙基氨基)甲基]-1-吡咯烷基]-6,8-二氟-1,4-二氢-4-氧代- |
英文别名 | CI 934 PD-114843 Aids007688 Aids-007688 Merafloxacin Quinolone cl-934 Merafloxacin (CI-934) 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 1-Ethyl-7-(3-((ethylamino)methyl)pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 3-Quinolinecarboxylic acid, 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo- |
CAS | 91188-00-0 |
化学式 | C19H23F2N3O3 |
分子量 | 379.4 |
存储条件 | -20℃ |
产品用途 | Merafloxacin, also known as CI 934, is a fluoroquinolone antibacterial, which was also identified as a −1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on −1 PRF of other beta coronaviruses. Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting −1 PRF as an effective antiviral strategy for SARS-CoV-2. |
参考资料 展开查看 | Sun Y, Abriola L, Surovtseva YV, Lindenbach BD, Guo JU. Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro. bioRxiv [Preprint]. 2020 Oct 21:2020.10.21.349225. doi: 10.1101/2020.10.21.349225. PMID: 33106809; PMCID: PMC7587830. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.636 ml | 13.179 ml | 26.357 ml |
5 mM | 0.527 ml | 2.636 ml | 5.271 ml |
10 mM | 0.264 ml | 1.318 ml | 2.636 ml |
5 mM | 0.053 ml | 0.264 ml | 0.527 ml |
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