946387-07-1
RN-1734(2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide)
CAS: 946387-07-1
化学式: C14H22Cl2N2O2S
| 中文名 | RN-1734 |
| 英文名 | 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide |
| 别名 | 化合物RN-1734 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺 |
| 英文别名 | RN-1734 RN 1734 TRPV4 Antagonist I, RN-1734 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide 2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734) 2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]- |
| CAS | 946387-07-1 |
| 化学式 | C14H22Cl2N2O2S |
| 分子量 | 353.31 |
| 溶解度 | DMSO: >20 mg/mL |
| 存储条件 | 2-8°C |
| 外观 | 黄色固体 |
| 颜色 | white to off-white |
| 体外研究 | RN-1734 (27 hours; 10μM) reverses the increase in the apoptotic rate of oligodendrocytes induced by CM (LPS-activated microglia group) apoptosis. RN-1734 (27 hours; 10μM) alleviates CM-induced decreases in CNP. Apoptosis Analysis Cell Line: Microglial cells Concentration: 27 hours Incubation Time: 10μM Result: Significantly decreased the percentage of cleaved-caspase 3 positive cells. Western Blot Analysis Cell Line: Microglial cells Concentration: 27 hours Incubation Time: 10 μM Result: Alleviated CM (with LPS only)-induced decreases in CNP. |
| 体内研究 | RN-1734 (0.5 μl; microinjector pump; daily for 5 weeks) significantly reverses the decrease in CNP protein and improves myelination in CPZ-induced demyelination mouse. Animal Model: CPZ-induced demyelination mouse model (C57BL/6 male mice) Dosage: 0.5 μl (10 μM in 5% DMSO and 0.9% NaCl) Administration: Microinjector pump for 5 weeks Result: Significantly reversed the decrease in CNP protein and improved myelination in CPZ-induced demyelination mouse. |
| WGK Germany | nwg |
946387-07-1 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.833 ml | 14.164 ml | 28.329 ml |
| 5 mM | 0.567 ml | 2.833 ml | 5.666 ml |
| 10 mM | 0.283 ml | 1.416 ml | 2.833 ml |
| 5 mM | 0.057 ml | 0.283 ml | 0.567 ml |
最后更新：2024-01-02 23:10:35
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现货供应
产品名: 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺 去供应商网站查看 询盘CAS: 946387-07-1
产地: 中国上海
包装: 25mg
规格: 98%
价格: 1718.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺 英文名:2,4-dichloro-N-isopropyl-N-[2-(isop 更多
现货供应
产品名: 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺 去供应商网站查看 询盘CAS: 946387-07-1
产地: 中国上海
包装: 25mg
规格: 98%
价格: 1718.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺 英文名:2,4-dichloro-N-isopropyl-N-[2-(isop 更多
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