AKTI-2008_化工百科

中文名	AKTI-2008
英文名	AKTI-2008
别名	化合物 T14152 AKT1变构抑制剂(AKT1 AND AKT2-IN-1) 3-苯基-2-[4-[[4-[5-(2-吡啶)-1H-1,2,4-三唑-3-基]-1-哌啶]甲基]苯基]-1,6-萘啶-5(6H)-酮
英文别名	Akti_2008 AKTI-2008 Akt1Akt2-IN-17 Akt1 and Akt2-IN-1 3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one 3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)-1,6-naphthyridin-5(6H)-one 1,6-Naphthyridin-5(6H)-one, 3-phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-
CAS	893422-47-4
化学式	C33H29N7O
分子量	539.63
存储条件	2-8℃
体外研究	Consistent with the allosteric mode of inhibition, Akt1 and Akt2-IN-1 (Compound 17) is dependent on the PH-domain for Akt inhibition, is selective for Akt1/2 over Akt3 (IC 50 =1900 nM), and is highly selective over other members of the AGC family of kinases (>50 μM vs PKA, PKC, SGK). Akt1 and Akt2-IN-1 (Compound 17) has moderate activity in an hERG binding assay (IC 50 =5610 nM) and is a substrate for human P-glycoprotein.
体内研究	Akt1 and Akt2-IN-1 (Compound 17) is well tolerated in at exposures that provide high levels of Akt1 and 2 inhibition in vivo. Akt1 and Akt2-IN-1 (Compound 17) has also been shown to inhibit the growth of A2780 tumors in vivo when used as monotherapy. Akt1 and Akt2-IN-1 (Compound 17) has potent inhibitory activity against Akt1 and 2 in vivo in a mouse lung and efficacy in a tumor xenograft model. Akt1 and Akt2-IN-1 (Compound 17) shows good pharmacokinetics in rat with a low clearance of 4.6 mL/min/kg and a half-life of 3.8 h. Due to the improved cell potency, physical properties, and rodent pharmacokinetics of Akt1 and Akt2-IN-1 (Compound 17), tolerability and Akt inhibition are assessed in mice. Using an acute dosing schedule (IP dosing of 50 mg/kg at times 0, 3, and 8 h), administration of Akt1 and Akt2-IN-1 (Compound 17) is well tolerated in mice and shows high levels of Akt inhibition in mouse lung.

AKTI-2008 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.853 ml	9.265 ml	18.531 ml
5 mM	0.371 ml	1.853 ml	3.706 ml
10 mM	0.185 ml	0.927 ml	1.853 ml
5 mM	0.037 ml	0.185 ml	0.371 ml

最后更新：2024-01-02 23:10:35

AKTI-2008 - 简介

AKTI-2008是一种化学物质，其化学名为2-氨基-2-甲基-1-丙醇（2-amino-2-methyl-1-propanol），也被称为丙醇胺或AMP。下面是关于AKTI-2008的性质，用途，制法和安全信息的介绍：

性质：AKTI-2008是无色或浅黄色液体，具有氨的气味。它易溶于水和醇，但不溶于非极性溶剂。AKTI-2008是碱性物质，其pH值约为10-11。

用途：AKTI-2008在化学工业中有广泛的用途。它常用作一种高效的中性化剂和缓冲剂，可以被用于调整化学反应体系的酸碱平衡。AKTI-2008还可以用作表面活性剂、乳化剂和溶解剂，在染料和颜料的制备过程中起到重要作用。

制法：AKTI-2008通常通过2-甲基-2-丙醇（2-methyl-2-propanol）与氨反应而得到。该反应是通过将氨气通入2-甲基-2-丙醇的醇溶液中进行。

安全信息：AKTI-2008是一种有机化合物，需要在使用过程中遵守相应的安全操作规程。它对眼睛和皮肤有刺激性，并且可能对呼吸道造成伤害。使用AKTI-2008时，应注意佩戴适当的防护设备，如手套、护目镜和呼吸防护器。在储存时，AKTI-2008需要避免与强酸、强氧化剂和易燃物接触，以防止意外事故的发生。

最后更新：2024-04-09 20:52:54

上海吉至生化科技有限公司

现货供应

产品名: 3-苯基-2-[4-[[4-[5-(2-吡啶)-1H-1,2,4-三唑-3-基]-1-哌啶]甲基]苯基]-1,6-萘啶-5(6H)-酮去供应商网站查看询盘
CAS: 893422-47-4
产地: 中国上海
包装: 100mg
规格: 99%
价格: 20998.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
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产品描述: 中文名：3-苯基-2-[4-[[4-[5-(2-吡啶)-1H-1,2,4-三唑-3-基]-1-哌啶]甲基]苯基]-1,6-萘啶-5(6H)-酮英文名:Akt1 更多

上海麦克林生化科技股份有限公司

现货供应

产品名: Akt1 and Akt2-IN-1 去供应商网站查看询盘
CAS: 893422-47-4
产地: 上海
规格: A876701
价格: 5mg-3325,10mg-4749
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320

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上海源叶生物科技有限公司

产品名: AKTI-2008 去供应商网站查看询盘
CAS: 893422-47-4
产地: 上海
规格: 99%
价格: 5mg 3500,10mg 5000
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403