BENZIMIDAVIR 苯并咪唑核苷
BENZIMIDAVIR(BENZIMIDAVIR)
CAS: 176161-24-3
化学式: C15H19Cl2N3O4
| 中文名 | BENZIMIDAVIR |
| 英文名 | BENZIMIDAVIR |
| 别名 | 马立巴韦 苯并咪唑核苷 BENZIMIDAVIR 苯并咪唑核苷 |
| 英文别名 | Maribavi Maribavir BENZIMIDAVIR 5,6-DICHLORO-2-ISOPROPYLAMINO-1-(-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE 5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(BETA-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE (2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]-imidazol-1-yl)-5-(hydroxymethyl)tetr |
| CAS | 176161-24-3 |
| 化学式 | C15H19Cl2N3O4 |
| 分子量 | 376.24 |
| 密度 | 1.67±0.1 g/cm3 (20 ºC 760 Torr) |
| 沸点 | 611.0±65.0 °C(Predicted) |
| 酸度系数 | 13.20±0.70(Predicted) |
| 存储条件 | 2-8°C(protect from light) |
| 体外研究 | Maribavir is a potent inhibitor of the autophosporylation of the wild type and all the major Ganciclovir (GCV) resistant UL97 mutants analysed with a mean IC 50 of 35 nM. The M460I mutation results in hypersensitivity to Maribavir with an IC 50 of 4.8 nM. A Maribavir resistant mutant of UL97 (L397R) is functionally compromised as both a Ganciclovir kinase and a protein kinase (~ 10% of wild type levels). Enzyme kinetic experiments demonstrate that Maribavir is a competitive inhibitor of ATP with a K i of 10 nM. Maribavir (1263W94) inhibits viral replication in a dose-dependent manner, with IC 50 of 0.12±0.01 μM as measured by a multicycle DNA hybridization assay. The pUL97 protein kinase is strongly inhibited by Maribavir, with 50% inhibition occurring at 3 nM. |
BENZIMIDAVIR 苯并咪唑核苷 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.658 ml | 13.29 ml | 26.579 ml |
| 5 mM | 0.532 ml | 2.658 ml | 5.316 ml |
| 10 mM | 0.266 ml | 1.329 ml | 2.658 ml |
| 5 mM | 0.053 ml | 0.266 ml | 0.532 ml |
最后更新：2024-01-02 23:10:35
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产品名: BENZIMIDAVIR 去供应商网站查看 询盘
CAS: 176161-24-3
产地: 上海
规格: 98%
价格: 5mg 1940,10mg 3400
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产品描述: BENZIMIDAVIR 98% MedMol 货号：S83964
CAS: 176161-24-3
产地: 上海
规格: 98%
价格: 5mg 1940,10mg 3400
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: BENZIMIDAVIR 98% MedMol 货号：S83964
产品名: BENZIMIDAVIR 去供应商网站查看 询盘
CAS: 176161-24-3
产地: 上海
规格: 98%
价格: 5mg 1940,10mg 3400
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: BENZIMIDAVIR 98% MedMol 货号：S83964
CAS: 176161-24-3
产地: 上海
规格: 98%
价格: 5mg 1940,10mg 3400
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: BENZIMIDAVIR 98% MedMol 货号：S83964
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