Maribavi
BENZIMIDAVIR
CAS: 176161-24-3
Molecular Formula: C15H19Cl2N3O4
Maribavi - Names and Identifiers
Maribavi - Physico-chemical Properties
| Molecular Formula | C15H19Cl2N3O4 |
| Molar Mass | 376.24 |
| Density | 1.67±0.1 g/cm3 (20 ºC 760 Torr) |
| Boling Point | 611.0±65.0 °C(Predicted) |
| pKa | 13.20±0.70(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| In vitro study | Maribavir is a potent inhibitor of the autophosporylation of the wild type and all the major Ganciclovir (GCV) resistant UL97 mutants analysed with a mean IC 50 of 35 nM. The M460I mutation results in hypersensitivity to Maribavir with an IC 50 of 4.8 nM. A Maribavir resistant mutant of UL97 (L397R) is functionally compromised as both a Ganciclovir kinase and a protein kinase (~ 10% of wild type levels). Enzyme kinetic experiments demonstrate that Maribavir is a competitive inhibitor of ATP with a K i of 10 nM. Maribavir (1263W94) inhibits viral replication in a dose-dependent manner, with IC 50 of 0.12±0.01 μM as measured by a multicycle DNA hybridization assay. The pUL97 protein kinase is strongly inhibited by Maribavir, with 50% inhibition occurring at 3 nM. |
Maribavi - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.658 ml | 13.29 ml | 26.579 ml |
| 5 mM | 0.532 ml | 2.658 ml | 5.316 ml |
| 10 mM | 0.266 ml | 1.329 ml | 2.658 ml |
| 5 mM | 0.053 ml | 0.266 ml | 0.532 ml |
Last Update：2024-01-02 23:10:35
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