BETA淀粉样蛋白片段1-40

中文名	β 淀粉样蛋白片段1-40
英文名	Amyloid β Protein Fragment 1-40
别名	Β淀粉样肽1-40 β 淀粉样蛋白片段1-40 Β 淀粉样蛋白片段1-40 淀粉样Β-蛋白(人,1-40) BETA淀粉样蛋白片段1-40 Β-淀粉样蛋白(1-40),人
英文别名	aβ40 AΒ40 Β-AMYLOID 1-40 SS-AMYLOID (1-40), RAT Amyloidb-Peptide(1-40)(human) M.W. 4329.86 C194H295N53O58S amyloid β protein fragment 1-40 AMYLOID B-PROTEIN FRAGMENT 1-40 Amyloid β Protein Fragment 1-40 Amyloid beta Protein fragment 1-40 HCl Salt AMYLOID BETA-PROTEIN (HUMAN, 1-40) TRIFLUOROACETATE H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Gly-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
CAS	131438-79-4
化学式	C194H295N53O58S
分子量	4329.8034
溶解度	H2O: ~ 6 mg/mL
存储条件	-20°C
外观	粉末
颜色	white
物化性质	生物活性 β-Amyloid (1-40) 是阿尔茨海默病患者脑斑块中发现的主要蛋白质。
MDL号	MFCD00130509
体外研究	β-Amyloid (1-40) and (1-42) are major components of senile plaque amyloids, are physiological peptides present in the brain, cerebrospinal fluid (CSF) and plasma. The levels of CSF β-Amyloid (1-40) and (1-42) show a U-shaped natural course in normal aging.Chronic infusion of beta-amyloid (1-40) for 14 days into the rat cerebroventricle decreased the activity of soluble protein kinase C (PKC) in the hippocampus. Subcellular translocation of PKC to membrane fraction in hippocampal slices of rats treated with beta-amyloid (1-40) is completely abolished under acute stimulation with 0.5 microM phorbol-dibutyrate (PDBu).The further aggregation of β-Amyloid (1-40) 1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure. 2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80°C. 3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing. 4. Next, the solution was age 48h at 4-8°C. The sample was then centrifuged at 14000g for 10 min at 4-8°C; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments. Methods vary depends on the downstream applications.
体内研究	Chronic infusion of β-Amyloid (1-40) into rat cerebroventricle leads to deficit in spatial and non-spatial memory formation. Chronic treatment of β-Amyloid (1-40) does not change lever-pressing performance significantly, but performance declined significantly 30 days after termination of the chronic daily regimen. The soluble unaggregated form of β-Amyloid (1-40), injected into the dorsal hippocampus, does not appear to have behavioral effects on performance or short-term working memory in rats, but multiple repeat injections produced performance decrements several weeks later. Repeated injection of β-Amyloid (1-40) through indwelling cannulae shows promise for development of an animal model of Alzheimer's disease.
WGK Germany	3

BETA淀粉样蛋白片段1-40 - 介绍

Amino Acid Sequence:Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

最后更新：2022-10-16 17:41:24

BETA淀粉样蛋白片段1-40 - 用途与合成方法

β淀粉样蛋白片段1-40是一种蛋白质片段，也被简称为Aβ 1-40。它是β淀粉样蛋白的主要组成部分之一，其 peptides 通过在细胞内的代谢过程中产生。

β淀粉样蛋白以及Aβ 1-40的用途：
研究阿尔茨海默病（Alzheimer's disease）：Aβ 1-40是阿尔茨海默病中形成淀粉样斑块的主要成分之一。研究人员使用Aβ 1-40来了解该病的发病机制和治疗方法。

合成方法：
Aβ 1-40的合成通常由化学合成方法完成。具体合成方法包括固相肽合成（solid-phase peptide synthesis）和液相肽合成（solution-phase peptide synthesis）。固相合成是最常用的方法，它基于将不同氨基酸通过酰氯（acyl chloride）或活化的酯（activated ester）与聚合物基质（resin）上的已固定氨基酸连接起来。随后利用逐步的反应和去保护（deprotection）步骤，将氨基酸连接起来，最终得到目标Aβ 1-40肽段。

在合成过程中，需要确保保护组的选择、连结反应、去保护反应的条件等，以确保高纯度、正确连接的Aβ 1-40得到合成。这样的合成方法经过多年的改进和优化，并且在研究中得到广泛应用。值得一提的是，在合成过程中需要严格控制实验室的条件和操作，以确保安全和避免污染。

最后更新：2024-04-09 21:54:55

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CAS: 131438-79-4
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产品名: Amyloid β Protein Fragment 1-40 去供应商网站查看询盘
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