BIBF0775
BIBF0775(BIBF0775)
CAS: 334951-90-5
化学式: C31H34N4O2
| 中文名 | BIBF0775 |
| 英文名 | BIBF0775 |
| 别名 | 化合物BIBF0775 (Z)-N-乙基-N-甲基-2-氧代-3-(苯基((4-(哌啶-1-基甲基)苯基)氨基)亚甲基)二氢吲哚-6-甲酰胺 |
| 英文别名 | BIBF0775 (3Z)-N-ethyl-N-methyl-2-oxo-3-[phenyl-[4-(piperidin-1-ylmethyl)anilino]methylidene]-1H-indole-6-carboxamide (Z)-N-Ethyl-N-methyl-2-oxo-3-(phenyl((4-(piperidin-1-ylmethyl)phenyl)amino)methylene)indoline-6-carboxamide 1H-Indole-6-carboxamide, N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-, (3Z)- |
| CAS | 334951-90-5 |
| 化学式 | C31H34N4O2 |
| 分子量 | 494.63 |
| 密度 | 1.223±0.06 g/cm3(Predicted) |
| 沸点 | 705.9±60.0 °C(Predicted) |
| 溶解度 | DMSO: 60 mg/mL( < 1 mg/mL指产品微溶或不溶) |
| 酸度系数 | 11.33±0.20(Predicted) |
| 存储条件 | Sealed in dry,Room Temperature |
| 靶点 | TGFβR1(ALK5); Alk5 |
| 参考资料 展开查看 | 1: Roth GJ, Heckel A, Brandl T, Grauert M, Hoerer S, Kley JT, Schnapp G, Baum P,Mennerich D, Schnapp A, Park JE. Design, synthesis, and evaluation of indolinonesas inhibitors of the transforming growth factor β receptor I (TGFβRI). J MedChem. 2010 Oct 28;53(20):7287-95. doi: 10.1021/jm100812a. PubMed PMID: 20919678. |
BIBF0775 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.022 ml | 10.109 ml | 20.217 ml |
| 5 mM | 0.404 ml | 2.022 ml | 4.043 ml |
| 10 mM | 0.202 ml | 1.011 ml | 2.022 ml |
| 5 mM | 0.04 ml | 0.202 ml | 0.404 ml |
最后更新：2024-01-02 23:10:35
BIBF0775 - 细胞实验
The high-content cytotoxicity assay (kit I) was performed according to the manufacturer’s instructions. HaCaT cells were cultured overnight in black 96-well plates, incubated for 24 h with each compound at different concentrations, and stained with cytotoxicity cocktail. Cells were fixed, washed, and scanned on the Cellomics ArrayScan II platform. Images were analyzed with the Cell Health image analysis algorithm. Cytotoxicity indices were calculated for each of the four parameters (cellular membrane integrity, nuclear fragmentation and density, and lysosomal mass) to indicate the percentage of cells outside of the normal range which was defined using a vehicle-treated reference cell population.
最后更新：2023-08-16 21:32:38
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现货供应
产品名: (Z)-N-乙基-N-甲基-2-氧代-3-(苯基((4-(哌啶-1-基甲基)苯基)氨基)亚甲基)二氢吲哚-6-甲酰胺 去供应商网站查看 询盘CAS: 334951-90-5
产地: 中国上海
包装: 5mg
规格: 97%
价格: 1196.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：(Z)-N-乙基-N-甲基-2-氧代-3-(苯基((4-(哌啶-1-基甲基)苯基)氨基)亚甲基)二氢吲哚-6-甲酰胺 英文名:(Z)-N-Ethyl-N 更多
现货供应
产品名: (Z)-N-乙基-N-甲基-2-氧代-3-(苯基((4-(哌啶-1-基甲基)苯基)氨基)亚甲基)二氢吲哚-6-甲酰胺 去供应商网站查看 询盘CAS: 334951-90-5
产地: 中国上海
包装: 5mg
规格: 97%
价格: 1196.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：(Z)-N-乙基-N-甲基-2-氧代-3-(苯基((4-(哌啶-1-基甲基)苯基)氨基)亚甲基)二氢吲哚-6-甲酰胺 英文名:(Z)-N-Ethyl-N 更多
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