BTZ043
BTZ043(BTZ043)
CAS: 1161233-85-7
化学式: C17H16F3N3O5S
| 中文名 | BTZ043 |
| 英文名 | BTZ043 |
| 别名 | 化合物BTZ043 DPRE1抑制剂(BTZ043) DPRE1抑制剂(PBTZ169) 2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮 |
| 英文别名 | BTZ043 CS-2310 PBTZ 169 BTZ 10526043 BTZ043 raceMate BTZ043 (BTZ-043 2-[(3S)-3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one 2-[(2S)-2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one |
| CAS | 1161233-85-7 |
| 化学式 | C17H16F3N3O5S |
| 分子量 | 431.39 |
| 密度 | 1.68 |
| 熔点 | 190-191°C |
| 溶解度 | 氯仿 (微溶)，甲醇 (非常微溶) |
| 存储条件 | -20°C Freezer |
| 外观 | 固体 |
| 颜色 | White to Pale Yellow |
| 体外研究 | The MIC of BTZ043 against M. tuberculosis H37Rv and Mycobacterium smegmatis are 1 ng/mL (2.3 nM) and 4 ng/mL (9.2 nM), respectively. The in vitro activity of BTZ043 against 30 Nocardia brasiliensis isolates is also tested. The MIC50 and MIC90 values for BTZ043 are 0.125 and 0.25 μg/mL. The MIC for N. carnea ATCC 6847 is 0.003μg/mL, for N. transvalensis ATCC 6865 is 0.003μg/mL, for N. brasiliensis NCTC10300 is 0.03 μg/mL, and for N. brasiliensis HUJEG-1 is 0.125μg/mL. The MIC value for M. tuberculosis H37Rv is 0.000976 μg/mL. The MIC value of BTZ-043 is >64 μg/mL for Escherichia coli ATCC 25922 and S. aureus ATCC 29213. |
| 体内研究 | Four weeks of treatment with BTZ043 reduces the bacterial burden in the lungs and spleens by 1 and 2 logs, respectively, at the concentrations used. Additional results suggest that BTZ043 efficacy is time-rather than dose-dependent. Acute (5 g/kg) and chronic (25 and 250 mg/kg) toxicology studies in uninfected mice show that, even at the highest dose tested, there are no adverse anatomical, behavioral, or physiological effects after one month. |
BTZ043 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.318 ml | 11.591 ml | 23.181 ml |
| 5 mM | 0.464 ml | 2.318 ml | 4.636 ml |
| 10 mM | 0.232 ml | 1.159 ml | 2.318 ml |
| 5 mM | 0.046 ml | 0.232 ml | 0.464 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: 2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮 去供应商网站查看 询盘CAS: 1161233-85-7
产地: 中国上海
包装: 50mg
规格: 99%
价格: 6798.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮 英文名:BTZ04 更多
现货供应
产品名: 2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮 去供应商网站查看 询盘CAS: 1161233-85-7
产地: 中国上海
包装: 50mg
规格: 99%
价格: 6798.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮 英文名:BTZ04 更多
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