CAY10505
CAY10505(CAY10505)
CAS: 1218777-13-9
化学式: C14H8FNO3S
| 中文名 | CAY10505 |
| 英文名 | CAY10505 |
| 别名 | PI3KΓ抑制剂(CAY10505) (5E)-5-[[5-(4-氟苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮 |
| 英文别名 | CAY10505 (E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione (5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione 2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-, (5E)- CAY10505 ( 5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione |
| CAS | 1218777-13-9 |
| 化学式 | C14H8FNO3S |
| 分子量 | 289.28 |
| 密度 | 1.466 |
| 酸度系数 | 7.21±0.20(Predicted) |
| 存储条件 | -20℃ |
| 体外研究 | A class IB PI3Kγ isoform inhibitor CAY10505 at 200 nM (IC 50 =30 nM) partially reduces the baicalein-induced Akt phosphorylation in neurons. The pharmacological PI3K inhibitor CAY10505 (PIK3CG) is tested on an extended panel of multiple myeloma (MM) cell lines and freshly isolated primary MM samples. MM cells are CAY10505-treated for 3 d (MM cell lines) or 5 d (primary MM cells) respectively, and survival is analysed by flow cytometry (annexin V-FITC/PI staining). Treatment of bone marrow stromal cells (BMSCs)-co-cultured primary MM samples with the PIK3CA inhibitor CAY10505 results in anti-survival effects (mean survival relative to DMSO-treated controls: CAY10505: 84±14%, tested at 10 μM). |
| 体内研究 | Administration of CAY10505 (0.6 mg/kg, p.o.), Losartan (25 mg/kg, p.o.), or Atorvastatin (30 mg/kg, p.o.) significantly increases serum nitrite and (or) nitrate concentrations in hypertensive rats. Acetylcholine (ACh) and Sodium nitroprusside (SNP) produce endothelium-dependent and-independent relaxation in isolated rat aortic ring precontracted with Phenylephrine (3 μM), in a dose dependent manner. Administration of CAY10505 (0.6 mg/kg,p.o.), Losartan (25 mg/kg, p.o.), or Atorvastatin (30 mg/kg, p.o.) significantly prevents hypertension-induced attenuation of ACh-induced endothelium-dependent relaxation. Deoxycorticosterone acetate salt (DOCA, 40 mg/kg, s.c.) induced hypertension markedly attenuates acetylcholine-induced endothelium-dependent relaxation, but does not affect SNP-induced endotheliumindependent relaxation. |
CAY10505 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.457 ml | 17.284 ml | 34.569 ml |
| 5 mM | 0.691 ml | 3.457 ml | 6.914 ml |
| 10 mM | 0.346 ml | 1.728 ml | 3.457 ml |
| 5 mM | 0.069 ml | 0.346 ml | 0.691 ml |
最后更新：2024-01-02 23:10:35
CAY10505 - 简介
CAY10505是一种化合物的名称，它是一种有机化合物。
最后更新：2024-04-10 22:29:15
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