DL-Carnitine hydrochloride
DL-肉碱盐酸盐(DL-Carnitine hydrochloride)
CAS: 461-05-2
化学式: C7H16ClNO3
| 中文名 | DL-肉碱盐酸盐 |
| 英文名 | DL-Carnitine hydrochloride |
| 别名 | 肉毒碱盐酸盐 混旋肉堿盐酸盐 混旋肉碱盐酸盐 DL-卡尼汀盐酸 DL-肉碱盐酸盐 DL-肉碱盐酸盐饲料级 DL-肉碱盐酸盐医药级 DL-肉碱盐酸盐(左卡尼汀杂质) |
| 英文别名 | DL-Carnitine HCl (Carnitine chloride DL-Carnitine hydrochloride dl-bicarnesine hydrochloride DL-Bicarnesine Hydrochloride (2,4-dihydroxy-4-oxo-butyl)-trimeth (3R)-3-hydroxy-4-(trimethylammonio)butanoate 3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium (2,4-dihydroxy-4-oxobutyl)-trimethylammonium chloride 3-hydroxy-4-trimethylazaniumylbutanoate hydrochloride 3-Hydroxy-4-(trimethylammonio)butanoate hydrochloride 3-hydroxy-4-trimethylazaniumyl-butanoate hydrochloride (2,4-dihydroxy-4-oxo-butyl)-trimethyl-ammonium chloride (2S)-3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium (2,4-dihydroxy-4-keto-butyl)-trimethyl-ammonium chloride 3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride N-(3-carboxy-2-hydroxypropyl)-N,N,N-trimethylammonium chloride |
| CAS | 461-05-2 |
| EINECS | 207-309-1 |
| 化学式 | C7H16ClNO3 |
| 分子量 | 197.66 |
| InChI | InChI=1/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H/p+1 |
| InChIKey | JXXCENBLGFBQJM-UHFFFAOYSA-N |
| 熔点 | 197-199°C |
| 比旋光度 | -0.2～+0.2°(20℃/D)(c=5,H2O) |
| 水溶性 | SOLUBLE |
| 溶解度 | 碱水溶液 (微溶)，甲醇 (微溶，加热)，水 (微溶，超声处理 |
| PH值 | 1.8-2.5 (100g/l, H2O) |
| 存储条件 | Store below +30°C. |
| 稳定性 | 吸湿性 |
| 敏感性 | Hygroscopic |
| 外观 | 粉末、晶体、针和/或块 |
| 颜色 | White to almost white |
| Merck | 14,1849 |
| BRN | 4163212 |
| 物化性质 | 熔点 190-205°C 水溶性 SOLUBLE |
| MDL号 | MFCD00011904 |
| 体外研究 | The main role of L-carnitine is to shuttle long-chain fatty acids across the inner mitochondrial membrane. After L-carnitine and acyl-CoA become acyl-carnitine by activation of carnitine palmitoyl transferase (CPT)-I, the transported acyl-carnitine is changed into acyl-CoA by CPT-II in the mitochondria matrix. Palmitoyl-CoA-induced mitochondrial respiration is increased by L-carnitine treatment, and then is accelerated by the presence of ADP. This acceleration is induced by treatment with L-carnitine in a concentration-dependent manner, and is saturated at 5 mM L-carnitine. Pretreatment with L-carnitine augments Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H 2 O 2 -treated HL7702 cells. L-carnitine protects HL7702 cells against H 2 O 2 -induced cell damage through Akt-mediated activation of Nrf2 signaling pathway. |
| 体内研究 | L-carnitine is found to down-regulate the ubiquitin proteasome pathway and increase IGF-1 concentrations in animal models. L-carnitine administration for 2 weeks of hindlimb suspension alleviates the decrease in weight and fiber size in the soleus muscle. In addition, L-carnitine suppresses atrogin-1 mRNA expression, which has been reported to play a pivotal role in muscle atrophy. Simultaneous treatment with L-carnitine attenuates the renal fibrosis (which correlated with a reduction of plasma TGF-β1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR-γ. |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 S37/39 - 戴适当的手套和护目镜或面具。 |
| WGK Germany | 3 |
| RTECS | BP2979140 |
| TSCA | Yes |
| 海关编号 | 29239000 |
| 上游原料 | 环氧氯丙烷 甲醇 |
DL-Carnitine hydrochloride - 简介
DL-肉碱盐酸盐是一种白色结晶粉末，化学名为4-羟基-3,4-二甲氧基苯乙胺盐酸盐。它是一种具有弱碱性的化合物。
它是一种常见的营养补充剂，用于增强体力、提高运动能力和减少脂肪堆积。它还常用于治疗心脏疾病和代谢紊乱等疾病，因其具有保护心脏和改善脂肪代谢的作用。
制备DL-肉碱盐酸盐的方法通常是将DL-肉碱与盐酸反应，生成肉碱盐酸盐，随后通过结晶获得纯品。生产中可采用化工合成或者微生物发酵的方法制取。
过量摄入可能导致副作用，如恶心、呕吐、腹泻等。
它是一种常见的营养补充剂，用于增强体力、提高运动能力和减少脂肪堆积。它还常用于治疗心脏疾病和代谢紊乱等疾病，因其具有保护心脏和改善脂肪代谢的作用。
制备DL-肉碱盐酸盐的方法通常是将DL-肉碱与盐酸反应，生成肉碱盐酸盐，随后通过结晶获得纯品。生产中可采用化工合成或者微生物发酵的方法制取。
过量摄入可能导致副作用，如恶心、呕吐、腹泻等。
最后更新：2024-04-09 20:52:54
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