(3R)-3-hydroxy-4-(trimethylammonio)butanoate
DL-Carnitine hydrochloride
CAS: 461-05-2
Molecular Formula: C7H16ClNO3
(3R)-3-hydroxy-4-(trimethylammonio)butanoate - Names and Identifiers
(3R)-3-hydroxy-4-(trimethylammonio)butanoate - Physico-chemical Properties
| Molecular Formula | C7H16ClNO3 |
| Molar Mass | 197.66 |
| Melting Point | 197-199°C |
| Specific Rotation(α) | -0.2～+0.2°(20℃/D)(c=5,H2O) |
| Water Solubility | SOLUBLE |
| Solubility | Aqueous Base (Slightly), Methanol (Slightly, Heated), Water (Sparingly, Sonicate |
| Appearance | White powder |
| Color | White to almost white |
| Merck | 14,1849 |
| BRN | 4163212 |
| PH | 1.8-2.5 (100g/l, H2O) |
| Storage Condition | Store below +30°C. |
| Stability | Hygroscopic |
| Sensitive | Hygroscopic |
| MDL | MFCD00011904 |
| Physical and Chemical Properties | Melting point 190-205°C water-SOLUBLE SOLUBLE |
| Use | For medicine, aquatic feed add nutrients, etc |
| In vitro study | The main role of L-carnitine is to shuttle long-chain fatty acids across the inner mitochondrial membrane. After L-carnitine and acyl-CoA become acyl-carnitine by activation of carnitine palmitoyl transferase (CPT)-I, the transported acyl-carnitine is changed into acyl-CoA by CPT-II in the mitochondria matrix. Palmitoyl-CoA-induced mitochondrial respiration is increased by L-carnitine treatment, and then is accelerated by the presence of ADP. This acceleration is induced by treatment with L-carnitine in a concentration-dependent manner, and is saturated at 5 mM L-carnitine. Pretreatment with L-carnitine augments Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H 2 O 2 -treated HL7702 cells. L-carnitine protects HL7702 cells against H 2 O 2 -induced cell damage through Akt-mediated activation of Nrf2 signaling pathway. |
| In vivo study | L-carnitine is found to down-regulate the ubiquitin proteasome pathway and increase IGF-1 concentrations in animal models. L-carnitine administration for 2 weeks of hindlimb suspension alleviates the decrease in weight and fiber size in the soleus muscle. In addition, L-carnitine suppresses atrogin-1 mRNA expression, which has been reported to play a pivotal role in muscle atrophy. Simultaneous treatment with L-carnitine attenuates the renal fibrosis (which correlated with a reduction of plasma TGF-β1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR-γ. |
(3R)-3-hydroxy-4-(trimethylammonio)butanoate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| RTECS | BP2979140 |
| TSCA | Yes |
| HS Code | 29239000 |
| Toxicity | LD50 subcutaneous in mouse: 6gm/kg |
(3R)-3-hydroxy-4-(trimethylammonio)butanoate - Upstream Downstream Industry
| Raw Materials | Epichlorohydrin Epichlorohydrin Methyl alcohol Methyl alcohol Trimethylamine Hydrochloric acid Hydrochloric acid |
(3R)-3-hydroxy-4-(trimethylammonio)butanoate - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| traits | white crystal or crystalline powder |
| use | mixed carnitine hydrochloride can be used as food additives and adjuvant therapeutic agents. used to add nutrients to medicine and aquatic feed, etc. |
| Biological activity | DL-Carnitine HCl is a quaternary ammonium compound for the biosynthesis of amino acids lysine and methionine. |
| category | toxic substances |
| toxicity classification | low toxicity |
| acute toxicity | subcutaneous-rat LD50: 10000 mg/kg; Subcutaneous-mouse LD50: 6000 mg/kg |
| flammability hazard characteristics | thermal decomposition discharges toxic nitrogen oxides and chloride smoke |
| storage and transportation characteristics | warehouse low temperature ventilation and drying |
| fire extinguishing agent | water, carbon dioxide, foam, dry powder |
Last Update：2024-04-09 20:52:54
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Product Name: DL-Carnitine hydrochloride Request for quotation
CAS: 461-05-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
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CAS: 461-05-2
Tel: 0086-551-65418684
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Raw Materials for (3R)-3-hydroxy-4-(trimethylammonio)butanoate