Davercin_化工百科

中文名	环酯红霉素
英文名	Davercin
别名	达发新大威霉素环酯红霉素红霉素杂质50 红霉素杂质10 环酯红霉素(大威霉素) (3AR,4R,7R,8S,9S,10R,11R,13R,15R,15AR)-10-(((2S,3R,4S,6R)-4-(二甲基氨基)-3-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-4-乙基-11-羟基-8-(((2R,4R,5S,6S)-5-羟基-4-甲氧基-4,6-二甲基四氢-2H-吡喃-2-基)氧基)-3A,7,9,11,13,15-六甲基八氢-3AH-[1,3]二氧杂戊环并[4,5-C][1]氧杂环十四烷-2,6,14(4H,7H)-三酮
英文别名	CWE Davercin DAVERCIN Erythromycin Cyclocarbonate Cykliczny weglan erytromycyny a Carbonato ciclico de eritromicina a Erythromycin A cyclic 11,12-carbonate erythromycin A cyclic 11,12-carbonate Carbonato ciclico de eritromicina A [spanish] (1R,2R,5R,6S,7S,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-6-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-1,5,7,9,11,13-hexamethyl-3,15,17-trioxabicyclo[12.3.0]heptadecane-4,12,16-trione (1R,2R,5R,6S,7S,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-6-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-1,5,7,9,11,13-hexamethyl-3,15,17-trioxabicyclo[12.3.0]heptadecane-4,12,16-trione (3aR,4R,7R,8S,9S,11R,13R,15R,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4-ethyl-11-hydroxy-8-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3a,7,9,11,13,15-hexamethyloctahydro-4H-[1,3]dioxolo[4,5-c]oxacyclotetradecine-2,6,14(3aH,7H)-trione (non-preferred name)
CAS	55224-05-0
化学式	C38H65NO14
分子量	759.93
InChI	InChI=1/C38H65NO14/c1-14-25-38(10)32(52-35(44)53-38)20(4)27(40)18(2)16-36(8,45)31(51-34-28(41)24(39(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-37(9,46-13)30(42)23(7)48-26/h18-26,28-32,34,41-42,45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30+,31?,32-,34+,36-,37-,38-/m1/s1
密度	1.22±0.1 g/cm3(Predicted)
熔点	>135°C (dec.)
沸点	859.8±65.0 °C(Predicted)
闪点	473.8°C
蒸汽压	1.91E-34mmHg at 25°C
溶解度	氯仿 (微溶) 、乙醇 (微溶) 、甲醇 (微溶)
折射率	1.534
酸度系数	13.49±0.70(Predicted)
存储条件	2-8°C
外观	固体
颜色	White
体外研究	Erythromycin is used in treatment of respiratory, gastrointestinal, and genital tract infections, as well as skin and soft tissue infections. Erythromycin, with its ten chiral centers and two sugar substituents (L-cladinose and D-desosamine), is a good starting point for numerous medicinal chemistry efforts for improvement of its biological profile (better activity, higher stability, and improved bioavailability) since the first generation of macrolides, which had low toxicity and good tolerability, are unstable in acidic media, had low toxicity and good tolerability.

Davercin - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.316 ml	6.58 ml	13.159 ml
5 mM	0.263 ml	1.316 ml	2.632 ml
10 mM	0.132 ml	0.658 ml	1.316 ml
5 mM	0.026 ml	0.132 ml	0.263 ml

最后更新：2024-01-02 23:10:35

Davercin - 简介

环酯红霉素是一种广谱抗生素，它属于大环内酯类抗生素家族的成员。它的化学名称为9-{O-[(2-{[4-{[(2-{[(2-{[(4-{[(2-{[(1R,2R,3S,4S,6R,8R,10R,11R,12S,13S,15S,17S)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-1-hydroxyethyl)-4-hydroxy-8-methyloxacyclotetradecan-2-yl]oxy}-5-ethyl-1,3,4-trioxopentan-2-yl]oxy}-15-hydroxy-13-methyl-1,5,7,9,14,16-hexaoxaoctadecan-12-yl]oxy}-6-methyl-1-oxobicyclo[11.2.1]hexadec-7-en-17-yl]carbonyl}-11,12-dihydroxy-4-[(2S,4R)-4-hydroxy-6-methyl-2-tetrahydropyranyl]-8-methoxy-1-methylethyl]-3,6,10,12,14,16-hexaoxohexadecan-1-yl}nonadecan-21-oate。

环酯红霉素具有优异的抗生物活性，可抑制多种细菌的生长。它主要应用于临床上治疗多种感染疾病，如呼吸道感染、皮肤软组织感染、耳鼻喉感染等。环酯红霉素还可用于治疗胃肠道感染和性传播疾病。

环酯红霉素的制备方法一般是通过将红霉素与环酯基团反应而得到。具体制备方法包括酯化反应、络合反应等。

最后更新：2024-04-09 20:52:54

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产品名: (3aR,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-(((2S,3R,4S,6R)-4-(二甲基氨基)-3-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-4-乙基-11-羟基-8-(((2R,4R,5S,6 去供应商网站查看询盘
CAS: 55224-05-0
产地: 北京
包装: 瓶
规格: YS102162-250mg,YS102162-100mg
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产品名: (3aR,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-(((2S,3R,4S,6R)-4-(二甲基氨基)-3-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-4-乙基-11-羟基-8-(((2R,4R,5S,6S)-5-羟基-4-甲氧基-4,6-二甲基四氢-2H-吡喃-2-基)氧基)-3a,7,9,11,13,15-六甲基八氢-3aH-[1,3]二氧杂戊环并[4,5-c][1]氧杂环十四烷-2,6,14(4H,7H)-三酮去供应商网站查看询盘
CAS: 55224-05-0
产地: 中国上海
包装: 10mg
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产品描述: 中文名：(3aR,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-(((2S,3R,4S,6R)-4-(二甲基氨基)-3-羟基-6-甲更多

上海麦克林生化科技股份有限公司

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产品名: 环酯红霉素去供应商网站查看询盘
CAS: 55224-05-0
产地: 上海
规格: E794781
价格: 1ml-1833,5mg-950,10mg-1600
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上海源叶生物科技有限公司

产品名: Davercin 去供应商网站查看询盘
CAS: 55224-05-0
产地: 上海
规格: 95%
价格: 5mg 1400,10mg 2400,25mg 3800
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