Exherin
Exherin(Exherin)
CAS: 229971-81-7
化学式: C22H34N8O6S2
| 中文名 | Exherin |
| 英文名 | Exherin |
| 别名 | ADH 1游离态 化合物EXHERIN (4R,7S,10S,13S,16R)-13-((1H-咪唑-5-基)甲基)-16-乙酰氨基-7-异丙基-10-甲基-6,9,12,15-四氧基-1,2-二硫基-5,8,11,14-四氮杂环庚烷-4-酰胺 |
| 英文别名 | ADH 1 CS-2142 Exherin Exherin TFA ADH-1 Exherin Exherin (ADH-1) L-Cysteinamide, N-acetyl-L-cysteinyl-L-histidyl-L-alanyl-L-valyl-, cyclic (1→5)-disulfide (4R,7S,10S,13S,16R)-13-((1H-Imidazol-5-yl)methyl)-16-acetamido-7-isopropyl-10-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraazacycloheptadecane-4-carboxamide |
| CAS | 229971-81-7 |
| 化学式 | C22H34N8O6S2 |
| 分子量 | 570.69 |
| 溶解度 | 10毫米DMSO |
| 存储条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| 体外研究 | ADH-1 (0.2 mg/mL) blocks collagen I-mediated changes in pancreatic cancer cells, and is highly effective at preventing cell motility that is induced by expression of N-cadherin. ADH-1 (0, 0.1, 0.2, 0.5 and 1.0 mg/mL) induces apoptosis in a dose-dependent and N-cadherin-dependent manner. |
| 体内研究 | ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells. ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model. ADH-1 (10 mL/kg, i.p.) augmentation of melanoma tumor growth is overcome through its ability to make regionally infused melphalan more effective. ADH-1 mediated augmentation of melanoma tumor growth is not altered by regionally infused temozolomide. In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts. |
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