GEFITINIB盐酸盐
盐酸吉非替尼(Gefitinib hydrochloride)
CAS: 184475-55-6
化学式: C22H24ClFN4O3.HCl
| 中文名 | 盐酸吉非替尼 |
| 英文名 | Gefitinib hydrochloride |
| 别名 | 盐酸吉非替尼 吉非替尼盐酸盐 吉非替尼原料药 EGFR酪氨酸激酶抑制剂 GEFITINIB盐酸盐 4-(3-氯-4-氟苯基氨基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉盐酸盐 |
| 英文别名 | Gefitinib Hcl Iressa hydrochloride ZD-1839 hydrochloride Gefitinib hydrochloride Gefitinib hydrochloride salt Gefitinib hydrochloride (ZD-1839 hydrochloride) 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine hydrochloride |
| CAS | 184475-55-6 |
| EINECS | 1533716-785-6 |
| 化学式 | C22H24ClFN4O3.HCl |
| 分子量 | 483.37 |
| InChI | InChI=1/C22H24ClFN4O3.ClH/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15;/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27);1H |
| 沸点 | 607.7°C at 760 mmHg |
| 闪点 | 321.3°C |
| 蒸汽压 | 4.9E-15mmHg at 25°C |
| 存储条件 | 2-8℃ |
| 体外研究 | Gefitinib (0.01-0.1 mM) results in increased phosphotyrosine load of the receptor, increased signalling to ERK and stimulation of proliferation and anchorage-independent growth, presumably by inducing EGFRvIII dimerisation in long-term exposure of EGFRvIII-expressing cells. On the other hand, gefitinib (1-2 mM) significantly decreases EGFRvIII phosphotyrosine load, EGFRvIII-mediated proliferation and anchorage-independent growth. Gefitinib (ZD1839) inhibits the monolayer growth of these EGF-driven untransformed cells with IC 50 of 20 nM. Gefitinib leads to an inhibition of CALU-3 and GLC82 cell proliferation, with an IC 50 of 2 μM. |
| 体内研究 | Gefitinib (150 mg/kg, p.o.) in conbination with Metformin induces a significant reduction in tumor growth in nude mice bearing H1299 or CALU-3 GEF-R cells that are grown subcutaneously as tumor xenografts. In irradiated rats, Gefitinib treatment augmentes lung inflammation, including inflammatory cell infiltration and pro-inflammatory cytokine expression, while Gefitinib treatment attenuates fibrotic lung remodeling due to the inhibition of lung fibroblast proliferation. |
供应商列表
现货供应
产品名: Gefitinib hydrochloride 去供应商网站查看 询盘CAS: 184475-55-6
产地: 上海
规格: Z873735
价格: 5mg-117,25mg-265,1ml-205
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
产品名: 4-(3-氯-4-氟苯基氨基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉盐酸盐 去供应商网站查看 询盘
CAS: 184475-55-6
产地: 上海
规格: 99%
价格: 100mg 460,500mg 920,1g 1250,5g 4500
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: 4-(3-氯-4-氟苯基氨基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉盐酸盐 99% 源叶 货号：S84081
CAS: 184475-55-6
产地: 上海
规格: 99%
价格: 100mg 460,500mg 920,1g 1250,5g 4500
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: 4-(3-氯-4-氟苯基氨基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉盐酸盐 99% 源叶 货号：S84081
现货供应
产品名: Gefitinib hydrochloride 去供应商网站查看 询盘CAS: 184475-55-6
产地: 上海
规格: Z873735
价格: 5mg-117,25mg-265,1ml-205
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
产品名: 4-(3-氯-4-氟苯基氨基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉盐酸盐 去供应商网站查看 询盘
CAS: 184475-55-6
产地: 上海
规格: 99%
价格: 100mg 460,500mg 920,1g 1250,5g 4500
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: 4-(3-氯-4-氟苯基氨基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉盐酸盐 99% 源叶 货号：S84081
CAS: 184475-55-6
产地: 上海
规格: 99%
价格: 100mg 460,500mg 920,1g 1250,5g 4500
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: 4-(3-氯-4-氟苯基氨基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉盐酸盐 99% 源叶 货号：S84081
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