KAVATIN_化工百科

中文名	麻醉椒苫素
英文名	methysticin
别名	麻醉椒苫素麻醉椒苦素 5,6-二氢-4-甲氧基-6-(3,4-(亚甲基二氧基)苯乙烯基)-2H-吡喃-2-酮
英文别名	KAVATIN KAVAHIN METHYSTICIN methysticin (±)-Methystici) Methysticin (DL-Methysticin 5,6-Dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)-2H-pyran-2-one (2S)-2-[(E)-2-(1,3-benzodioxol-5-yl)vinyl]-4-methoxy-2,3-dihydropyran-6-one (6S)-6-[(E)-2-(1,3-Benzodioxol-5-yl)vinyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one 2H-Pyran-2-one, 6-[(1E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy- 2H-pyran-2-one, 6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, (6S)-
CAS	20697-20-5
化学式	C15H14O5
分子量	274.27
InChI	InChI=1/C15H14O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h2-6,8,11H,7,9H2,1H3/b4-2+/t11-/m1/s1
密度	1.31±0.1 g/cm3(Predicted)
熔点	129-131 °C
沸点	496.5±45.0 °C(Predicted)
闪点	223.9°C
蒸汽压	5.39E-10mmHg at 25°C
溶解度	氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。
折射率	1.597
存储条件	2-8℃
外观	粉末
体外研究	Methysticin triggers the most profound inducing effect on CYP1A1. Consistent with the experimental results, in silico molecular docking studies based on the aryl hydrocarbon receptor (AhR)-ligand binding domain homology model also reveals favorable binding to AhR for Methysticin compared with the remaining kavalactones. Additionally, results from a luciferase gene reporter assay suggested that kava extract, Methysticin is able to activate the AhR signaling pathway. Kava extract induces the expression of CYP1A1 via an AhR-dependent mechanism and that Methysticin contributes to CYP1A1 induction. The induction of CYP1A1 indicates a potential interaction between kava or kavalactones and CYP1A1-mediated chemical carcinogenesis. The MTS cell viability assay is used to determine the effects of kava extract and kavalactones on cell viability in mouse hepatic cells. Hepa1c1c7 cells are treated with various concentrations of kava extract (0-50 µg/mL) and six kavalactones (0-100 µM) for 24 h. The results indicate that kava extract at concentrations up to 50 µg/mL and kavalactones up to 100 µM do not induce cell death. For the following studies, kava extract at 0.78-6.25 µg/mL and kavalactones at 0.78-25 µM, concentrations that cause no damage to cells, are used.
体内研究	The kavalactone Methysticin (6 mg/kg) is administered once a week for a period of 6 months to 6 month old transgenic APP/Psen1 mice by oral gavage. Methysticin treatment activates the Nrf2 pathway in the hippocampus and cortex of mice. The Aβ deposition in brains of Methysticin-treated APP/Psen1 mice is not altered compared to untreated mice. However, Methysticin treatment significantly reduces microgliosis, astrogliosis and secretion of the pro-inflammatory cytokines TNF-α and IL-17A. Methysticin treatment results in a significant activation of the Nrf2/ARE pathway in hippocampus and the cortex but not in the midbrain and cerebellum of ARE-luciferase reporter gene mice. Methysticin treatment significantly increases the expression of both genes compared to untreated animals.

KAVATIN - 简介

麻醉椒苫素（Capsaicin）是一种天然产物，主要存在于辣椒中。以下是关于麻醉椒苫素的性质、用途、制法和安全信息的详细介绍：

性质：
麻醉椒苫素是一种无色结晶，外观微黄色，具有强烈的辣味和刺激性。它在液体中不溶于水，但可溶于有机溶剂如乙醇和乙醚。

用途：它通过刺激神经末梢，达到镇痛和消炎的效果。

制法：
麻醉椒苫素的制法通常是从辣椒中提取得到。辣椒研磨成粉末后，用乙醇或乙醚等溶剂进行提取，然后通过蒸馏和结晶得到纯净的麻醉椒苫素。

安全信息：
麻醉椒苫素具有辣椒的辣味和刺激性，接触到皮肤、眼睛和呼吸道时可能引起疼痛、刺激和灼伤。
过量的麻醉椒苫素摄入可能导致胃肠道不适和消化不良。

最后更新：2024-04-09 19:05:04

上海吉至生化科技有限公司

现货供应

产品名: 麻醉椒苫素去供应商网站查看询盘
CAS: 20697-20-5
产地: 中国上海
包装: 10mg
规格: 分析对照品,HPLC≥98%
价格: 1768.00
库存: 10个工作日
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产品描述: 中文名：麻醉椒苫素英文名:methysticin CAS:20697-20-5 规格:分析对照品,HPLC≥98% 产地:中国上海

上海麦克林生化科技股份有限公司

现货供应

产品名: Methysticin 去供应商网站查看询盘
CAS: 20697-20-5
产地: 上海
规格: M880620
价格: 5mg-1231,10mg-1846
库存: 现货
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