LEVCROMAKALIM_化工百科

中文名	LEVCROMAKALIM
英文名	LEVCROMAKALIM
别名	左色满卡林左克罗卡林
英文别名	brl38227 lemakalim LEVCROMAKALIM levcromakelim (3s-trans)-yrrolidinyl) 2h-1-benzopyran-6-carbonitrile,3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p (3S,4R)-3β-Hydroxy-4-(2-oxopyrrolizino)-2,2-dimethyl-3,4-dihydro-6-cyano-2H-1-benzopyran (3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE
CAS	94535-50-9
化学式	C16H18N2O3
分子量	286.33
密度	1.31±0.1 g/cm3(Predicted)
熔点	242-244°
沸点	482.3±45.0 °C(Predicted)
比旋光度	D26 -52.2° (c = 1 in chloroform)
溶解度	DMSO: ≤ 10毫米，可溶
酸度系数	13.18±0.60(Predicted)
存储条件	Store at RT
外观	固体
体外研究	Levcromakalim ((-)-Cromakalim) inhibits spontaneous contractions completely in a glibenclamide-sensitive manner. LevCromakalim (5 µM) inhibits spontaneous contractions, which are recovered by glibenclamide. Levcromakalim (1, 5 and 10 µM) inhibits phasic contractions to 34±21.1%, 20.1±20.0% and 0% of the control (n=5, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions caused by LevCromakalim (5 µM) to 84±1.5% of the control (n=5; P<0.05). Levcromakalim (20 and 100 µM) also inhibits oxytocin (OXT) (10 nM)-induced phasic contractions to 34±21.4% and 14±12.6% of the control (n=6 and 4, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions by LevCromakalim (100 µM) to 79±3.5% of the control (n=4; P<0.05). Tonic contraction by OXT is also suppressed by Cromakalim in a glibenclamide-sensitive manner.The function of the K ATP channels is examined with the specific channel opener LevCromakalim (Cromakalim). LevCromakalim induces dose-dependent relaxation in both the young and old mesenteric artery (MAs); and there is no difference in relaxation with age. However, the relaxation is markedly reduced in response to the high-salt (HS) diet in the old MAs (P<0.05). Maximum dilations to Levcromakalim (10 -4 M) are 97 ± 3% in the young MAs versus 98 ± 1% in the young salt arteries, while dilations are 99±0.7% in the old MAs when compared with 85 ± 5% in the old salt arteries (P<0.05).
安全术语	S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。
WGK Germany	3
RTECS	DJ2177500

LEVCROMAKALIM - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.492 ml	17.462 ml	34.925 ml
5 mM	0.698 ml	3.492 ml	6.985 ml
10 mM	0.349 ml	1.746 ml	3.492 ml
5 mM	0.07 ml	0.349 ml	0.698 ml

最后更新：2024-01-02 23:10:35

上海吉至生化科技有限公司

现货供应

产品名: 左克罗卡林去供应商网站查看询盘
CAS: 94535-50-9
产地: 中国上海
包装: 50mg
规格: 99%
价格: 6798.00
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产品描述: 中文名：左克罗卡林英文名:Levcromakalim CAS:94535-50-9 规格:99% 产地:中国上海

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产品名: Levcromakalim 去供应商网站查看询盘
CAS: 94535-50-9
产地: 上海
规格: L876225
价格: 5mg-1300,2mg-866
库存: 7天内发货
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产品名: LEVCROMAKALIM 去供应商网站查看询盘
CAS: 94535-50-9
产地: 上海
规格: 99%
价格: 5mg 1200,10mg 1650,50mg 6800
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