Lexacalcitol_化工百科

中文名	Lexacalcitol
英文名	Lexacalcitol
别名	来沙骨化醇化合物 T15745
英文别名	KH 106 KH 1060 Lexacalcitol Lenosacalcitol Lexacalcideferol (1S,3R,5Z),7aalpha))-(5Z,7E,20R)-20-((4-Ethyl-4-hydroxyhexyl)oxy)-9,10-secopregna-5,7,10(19)-triene-1alpha,3beta-diol 1,3-Cyclohexanediol, 5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-[(4-ethyl-4-hydroxyhexyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)- (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-(4-ethyl-4-hydroxyhexoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CAS	131875-08-6
化学式	C29 H48 O4
分子量	460.69
密度	1.07±0.1 g/cm3(Predicted)
沸点	600.3±55.0 °C(Predicted)
酸度系数	14.43±0.40(Predicted)
存储条件	-20℃
体外研究	Lexacalcitol inhibits cell proliferation by 50% at 10 -12 M (14,000 times more active than la,25(OH) 2 D 3 ) in human histiocytic lymphoma cell line U 937. Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10 -16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10 -15 M.
体内研究	Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients. Animal Model: Male and female spontaneously diabetic NOD mice Dosage: 0.5 mg/kg/2 days Administration: Intraperitoneal injection Result: Single treatment with KH1060 or CyA did not result in statistically significant suppression of early graft failure, while the combination of KH1060 and CyA can prevent early graft failure and delay graft rejection of xenogeneic islets in spontaneously diabetic NOD mice.

Lexacalcitol - 介绍

Lexacalcitol (KH1060)的活性是1alpha,25-(OH)2D3的100倍。

最后更新：2022-10-16 17:42:01

上海吉至生化科技有限公司

现货供应

产品名: 来沙骨化醇去供应商网站查看询盘
CAS: 131875-08-6
产地: 中国上海
包装: 1mg
规格: 99%
价格: 3498.00
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产品描述: 中文名：来沙骨化醇英文名:Lexacalcitol CAS:131875-08-6 规格:99% 产地:中国上海

上海麦克林生化科技股份有限公司

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产品名: Lexacalcitol 去供应商网站查看询盘
CAS: 131875-08-6
产地: 上海
规格: L883257
价格: 1mg-1843,5mg-7601
库存: 7天内发货
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上海源叶生物科技有限公司

产品名: Lexacalcitol 去供应商网站查看询盘
CAS: 131875-08-6
产地: 上海
规格: 98%
价格: 1mg 1950,5mg 8050
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