Lusaperidone_化工百科

中文名	LUSAPERIDONE
英文名	LUSAPERIDONE
别名	化合物 T11894
英文别名	R107474 LUSAPERIDONE Lusaperidone [inn] 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-(3,4-dihydrobenzofuro[3,2-c]pyridin-2(1H)-yl)ethyl]-2-methyl- 2-Methyl-3-[2-(1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-2-yl)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one
CAS	214548-46-6
化学式	C22H21N3O2
分子量	359.42
密度	1.31±0.1 g/cm3(Predicted)
沸点	538.3±60.0 °C(Predicted)
酸度系数	6.93±0.20(Predicted)
存储条件	Room Temprature
体外研究	Lusaperidone has subnanomolar affinity for α2A and α2C adrenergic receptor (K i =0.13 and 0.15 nM, respectively) and shows nanomolar affinity for the hα2B adrenergic receptor and h5-HT7 receptors (K i =1 and 5 nM, respectively). Lusaperidone interacts weakly (K i values ranging between 81 and 920 nM) with dopamine-hD2L, -hD3 and -hD4, h5-HT1D-, h5-HT1F-, h5-HT2A-, h5-HT2C-, and h5-HT5A receptors. Lusaperidone, tested up to 10 μM, interacts only at micromolar concentrations or not at all with any of the other receptor or transporter binding sites tested in this study. Lusaperidone has been shown to reverse the clonidine-induced inhibition of cyclic AMP production mediated by human α2A and α2C adrenoceptors expressed in cell lines (K b is 2.8 and 4.4 nM, respectively) and is a full antagonist on both receptor subtypes.
体内研究	Lusaperidone occupies the α2A and α2C adrenergic receptor with an ED 50 of 0.014 mg/kg sc (0.009-0.019) and 0.026 mg/kg sc (0.022-0.030), respectively. The uptake of R107474 after in vivo intravenous administration is very rapid; in most tissues (including the brain) it reaches maximum concentration at 5 min after tracer injection.

北京索莱宝科技有限公司

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产品名: Lusaperidone 去供应商网站查看询盘
CAS: 214548-46-6
产地: 北京
包装: 5mg/瓶;
规格: IL3890-5mg
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上海麦克林生化科技股份有限公司

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产品名: Lusaperidone 去供应商网站查看询盘
CAS: 214548-46-6
产地: 上海
规格: L880439
价格: 1mg-1830,5mg-3659
库存: 7天内发货
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上海源叶生物科技有限公司

产品名: LUSAPERIDONE 去供应商网站查看询盘
CAS: 214548-46-6
产地: 上海
规格: ≥97%
价格: 1mg 2440,5mg 4880
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