Merimepodib_化工百科

中文名	Merimepodib
英文名	Merimepodib
别名	美泊地布 (S)-四氢呋喃-3-基 3-(3-(3-甲氧基-4-(恶唑-5-基)苯基)脲基)苄基氨基甲酸酯
英文别名	MMP VX497 VX-497 VX 497 VI21497 VI 21497 VI-21497 VI 21497 Merimepodib MERIMEPODIB MeriMepodib, VI-21497, VX-497 (S)-Tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate [(3S)-oxolan-3-yl] N-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate [[3-[[[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]carbamic acid (3S)-tetrahydro-3-furanyl ester Carbamic acid, N-[[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]-, (3S)-tetrahydro-3-furanyl ester
CAS	198821-22-6
化学式	C23H24N4O6
分子量	452.46
密度	1.36±0.1 g/cm3(Predicted)
沸点	571.4±50.0 °C(Predicted)
溶解度	DMSO: ≥ 31 mg/mL
酸度系数	11.66±0.46(Predicted)
存储条件	Sealed in dry,Room Temperature
体外研究	VX-497 has antiproliferative effect on lymphoid and keratinocyte cells. The antiproliferative effect of VX-497 in cells is reversed within 48 h of its removal. VX-497 has intermediate antiviral activity against a second group of viruses, which includes HSV-1, parainfluenza-3 virus, BVDV, VEEV, and dengue virus, with IC 50 s ranging from 6 to 19 μM. VX-497 is 100-fold more potent, with an IC 50 of 380 nM and a corresponding CC 50 of 5.2 μM, for a therapeutic index of 14. The antiviral activity of VX-497 in HepG2.2.2.15 cells is reversed threefold by the addition of guanosine.
体内研究	Oral administration of VX-497 inhibits the primary IgM antibody response in a dose-dependent manner, with an ED 50 value of appr 30-35 mg/kg in mice. Single daily dosing of VX-497 is observed to be as effective as twice-daily dosing in this model of immune activation. GVHD developed in the vehicle-treated allografted F1 mice and treatment with VX-497 improved all manifestations of the disease significantly. The 2.9-fold increase in spleen weight in allografted animals is reduced to a 1.6-fold increase in the VX-497-treated mice. Serum IFN-gamma levels are increased 54-fold in the vehicle group while there is a 7.4-fold increase in VX-497-treated animals.

Merimepodib - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.21 ml	11.051 ml	22.101 ml
5 mM	0.442 ml	2.21 ml	4.42 ml
10 mM	0.221 ml	1.105 ml	2.21 ml
5 mM	0.044 ml	0.221 ml	0.442 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

提供多种规格现货供应

产品名: (S)-四氢呋喃-3-基 3-(3-(3-甲氧基-4-(恶唑-5-基)苯基)脲基)苄基氨基甲酸酯去供应商网站查看询盘
CAS: 198821-22-6
产地: 北京
包装: 瓶
规格: YS107934-5mg,YS107934-2mg
价格: 电话、微信、QQ、邮件
库存: 一周左右
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036

微信: 17801761073
产品描述: 索莱宝直销，欢迎来询

上海吉至生化科技有限公司

现货供应

产品名: (S)-四氢呋喃-3-基 3-(3-(3-甲氧基-4-(恶唑-5-基)苯基)脲基)苄基氨基甲酸酯去供应商网站查看询盘
CAS: 198821-22-6
产地: 中国上海
包装: 5mg
规格: 98%
价格: 1082.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013

微信: 18017137653
产品描述: 中文名：(S)-四氢呋喃-3-基 3-(3-(3-甲氧基-4-(恶唑-5-基)苯基)脲基)苄基氨基甲酸酯英文名:Merimepodib CAS:198821- 更多

上海麦克林生化科技股份有限公司

现货供应

产品名: Merimepodib 去供应商网站查看询盘
CAS: 198821-22-6
产地: 上海
规格: M880785
价格: 5mg-1120,2mg-750,1ml-886
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320

微信: 19863730987/17821173903

上海源叶生物科技有限公司

现货供应

产品名: Merimepodib 去供应商网站查看询盘
CAS: 198821-22-6
产地: 上海
规格: 98%
价格: 2mg 480,5mg 800,10mg 1440,25mg 2720,50mg 4800,100mg 7200
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403