N-羟基琥珀酰亚胺(N-羟基丁二酰亚胺)
N-羟基丁二酰亚胺(N-Hydroxy succinimide)
CAS: 6066-82-6
化学式: C4H5NO3
| 中文名 | N-羟基丁二酰亚胺 |
| 英文名 | N-Hydroxy succinimide |
| 别名 | 羟基丁二酰亚胺 N-羟基丁亚二酰胺 N-羟基琥珀酰亚胺 N-羟基丁二酰亚胺 N-N-羟基琥珀酰亚胺 N-羟基丁二酰亚胺(+4℃) N-羟基丁二酰亚胺(HOSu) N-羟基琥珀酰亚胺 (HOSU) N-羟基琥珀酰亚胺(N-羟基丁二酰亚胺) N-羟基丁二酰亚胺(N-羟基琥珀酰亚胺) N-羟基琥珀酰亚胺(HOSU)|N-羟基丁二酰亚胺 |
| 英文别名 | NHS HOSu HONSU NHS OR HONSU N-HYDROXYSUCCINIMDE 1-Hydroxysuccinimide N-HYDROXYSUCCINIMIDE N-Hydroxysuccinimide N-Hydroxy succinimide NHS N-HYDROXYSUCCINIMIDE, N-Hydroxysuccinimide (HOSu) 1-hydroxy-5-pyrrolidinedione 5-Pyrrolidinedione,1-hydroxy-2 N-HYDROXY-2,5-PYRROLIDINEDIONE 1-hydroxypyrrolidine-2,5-dione 1-Hydroxy-2,5-pyrrolidinedione 1-Hydroxy-2,5-pyrrolidine-dione N-HYDROXYSUCCINIMIDE POLYMER-BOUND N-Hydroxysuccinimide POLYMER-BOUND HOSu~1-Hydroxy-2,5-pyrrolidinedione |
| CAS | 6066-82-6 |
| EINECS | 228-001-3 |
| 化学式 | C4H5NO3 |
| 分子量 | 115.09 |
| InChI | InChI=1/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2 |
| InChIKey | NQTADLQHYWFPDB-UHFFFAOYSA-N |
| 密度 | 1.4769 (rough estimate) |
| 熔点 | 95-98°C(lit.) |
| 沸点 | 215.33°C (rough estimate) |
| 闪点 | 112.5°C |
| 水溶性 | SOLUBLE |
| 蒸汽压 | 0Pa at 25℃ |
| 溶解度 | DMSO (可溶) 、甲醇 (微溶) |
| 折射率 | 1.4080 (estimate) |
| 酸度系数 | 7.81±0.20(Predicted) |
| PH值 | 5-7 (50g/l, H2O, 20℃) |
| 存储条件 | Store at +2°C to +8°C. |
| 稳定性 | 稳定。与强氧化剂、酰氯、酸酐、强碱不相容。防潮。 |
| 敏感性 | Hygroscopic |
| 外观 | 液体或固体 |
| 颜色 | Clear yellow-brown to brown |
| BRN | 113913 |
| 物化性质 | 白色结晶体。熔点99-100℃。 |
| MDL号 | MFCD00005516 |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
| WGK Germany | 3 |
| TSCA | Yes |
| 海关编号 | 29251995 |
| Hazard Note | Irritant |
| 上游原料 | 丁二酸酐 盐酸羟胺 |
| 下游产品 | 咪达普利 N-丙烯酰氧基琥珀酰亚胺 阿贝卡星 |
| 参考资料 展开查看 | 1. 肖福兵, 杨欣, 田锐,等. 基于石墨烯-海藻酸钠复合材料的辣根过氧化物酶传感器研究[J]. 化学传感器, 2014, 000(001):57-63. 2. 马舒伟, 刘兴艳, 辛杨,等. 银杏内酯K的PLGA-PEG纳米粒制备,表征和神经保护活性评价[J]. 中草药, 2019, 050(007):1562-1568. 3. 陈卓 石蕊 谭李玉 等. DHA-丝裂霉素C偶联前药的制备及角膜透过性研究[J]. 中国油脂 2017(8). 4. 宗云鹤 刘泓 毛详双 等. IRMOF3的合成后修饰(PSM)及其生物碱吸附研究[J]. 南开大学学报(自然科学版) 2019. 5. 赵德路, 铁朝荣, 王新,等. 复合锶离子光交联海藻酸盐水凝胶支架的机械和生物学性能[J]. 中国组织工程研究, 2019, 23(018):2880-2887. 6. 高先娟, 汲霞, 王清路,等. 羧基化石墨烯/半胱胺修饰金电极对多巴胺的电化学行为研究[J]. 生物技术进展, 2020, v.10;No.57(03):82-88. 7. 王新, 铁朝荣, 尹苗,等. 铜离子光双交联海藻酸盐水凝胶支架材料的性能研究[J]. 临床口腔医学杂志, 2020, 036(002):84-88. 8. 杨琳燕,王笑,宗云鹤,扈立伟,臧莲娜,艾霞,李存,金天明.基于γ-Fe_2O_3磁性纳米微球的MSPE研究[J].南开大学学报(自然科学版),2018,51(01):101-105. 9. 陈洋洋, 耿雪, 屈子卉,等. 熊果酸/PF127/TPGS-多柔比星混合纳米胶束的制备及其体外释药特性研究[J]. 中国药房, 2019(20). 10. 汤玉娇, 戴诗岩, 周羽婷,等. 基于DNA模板点击化学和催化发夹型DNA自组装反应的新型均相电化学生物传感器检测miRNA-21[J]. 分析化学, 2019(7):1029-1034. 11. 辛亮亮,舒玥,刘欢,胡雅稳,杨琳燕.PEG修饰Fe_3O_4纳米粒子（MNPs）的制备及载药研究[J].天津农学院学报,2020,27(03):43-48. 12. Cheng, Dan, et al. "An electrochemical DNA sensing platform using carboxyl functionalized graphene as the electrode modified material." Journal of The Electrochemical Society 164.6 (2017): H345. 13. Cheng, Dan, et al. "A non-enzymatic electrochemical sensing platform based on hemin@ MOF composites for detecting hydrogen peroxide and DNA." Journal of The Electrochemical Society 165.16 (2018): B885. 14. Yang, Dongcheng, et al. "An efficient method for the synthesis of a polymer brush via click chemistry and its ultrasensitive electrochemical detection of AFP." Analytical Methods 10.20 (2018): 2390-2397.https://doi.org/10.1039/C8AY00583D 15. He, B., Du, G. Novel electrochemical aptasensor for ultrasensitive detection of sulfadimidine based on covalently linked multi-walled carbon nanotubes and in situ synthesized gold nanoparticle composites. Anal Bioanal Chem 410, 2901–2910 (2018). https://do 16. Zhang, Yujie, et al. "Gold nanoclusters for controlled insulin release and glucose regulation in diabetes." Nanoscale 11.13 (2019): 6471-6479.https://doi.org/10.1039/C9NR00668K 17. Ai-Yue Hao, Xue-Qing Wang, Yan-Zhen Mei, Jun-Fang Nie, Ya-Qiong Yang, Chuan-Chao Dai,A smartphone-combined ratiometric fluorescence probe for specifically and visibly detecting cephalexin,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscop 18. Gao, Pengfei, et al. "Ferrocene-Modified Metal–Organic Frameworks as a Peroxidase-Mimicking Catalyst." Catalysis Letters 151.2 (2021): 478-486.https://doi.org/10.1007/s10562-020-03314-9 19. Li, MK., Hu, LY., Niu, CG. et al. A fluorescent DNA based probe for Hg(II) based on thymine-Hg(II)-thymine interaction and enrichment via magnetized graphene oxide. Microchim Acta 185, 207 (2018). https://doi.org/10.1007/s00604-018-2689-6 20. Sun, Xiuhua, et al. "Creation of antifouling microarrays by photopolymerization of zwitterionic compounds for protein assay and cell patterning." Biosensors and Bioelectronics 102 (2018): 63-69.https://doi.org/10.1016/j.bios.2017.11.001 21. Zhao, Delu, et al. "Effect of altering photocrosslinking conditions on the physical properties of alginate gels and the survival of photoencapsulated cells." Polymer Degradation and Stability 179 (2020): 109297.https://doi.org/10.1016/j.polymdegradstab.202 22. Zhou, Mou, et al. "Development of nanosilver doped carboxymethyl chitosan-polyamideamine alginate composite dressing for wound treatment." International Journal of Biological Macromolecules 166 (2021): 1335-1351.https://doi.org/10.1016/j.ijbiomac.2020.11.0 23. Li, Xiangyu, et al. "Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis." RSC Advances 11.6 (2021): 3567-3574.https://doi.org/10.1039/D0RA08689D 24. Lin, Zefeng, et al. "Biofunctions of antimicrobial peptide-conjugated alginate/hyaluronic acid/collagen wound dressings promote wound healing of a mixed-bacteria-infected wound." International journal of biological macromolecules 140 (2019): 330-342.https: 25. Liang, Ying, et al. "A label-free immunosensor based on PHEMA/graphene oxide nanocomposite for simultaneous electrochemical determination of alpha fetoprotein." RSC advances 9.30 (2019): 17187-17193. 26. Zhang, Haichao, et al. "Deterministic Lateral Displacement-Based Separation of Magnetic Beads and Its Applications of Antibody Recognition." Sensors 20.10 (2020): 2846.https://doi.org/10.3390/s20102846 27. Chen, S., Li, Y., Wu, S. et al. A phosphorescent probe for cephalexin consisting of mesoporous thioglycolic acid-modified Mn:ZnS quantum dots coated with a molecularly imprinted polymer. Microchim Acta 187, 40 (2020). https://doi.org/10.1007/s00604-019-403 28. [IF=10.618] Xiuhua Sun et al."Creation of antifouling microarrays by photopolymerization of zwitterionic compounds for protein assay and cell patterning."Biosens Bioelectron. 2018 Apr;102:63 29. [IF=7.46] Meng-Ke Li et al."A magnetic separation fluorescent aptasensor for highly sensitive detection of bisphenol A."Sensor Actuat B-Chem. 2018 Aug;266:805 30. [IF=6.4] Yishun Yang et al."Reduction-sensitive CD44 receptor-targeted hyaluronic acid derivative micelles for doxorubicin delivery."Int J Nanomed. 2018; 13: 4361–4378 31. [IF=5.833] Li Meng-Ke et al."A fluorescent DNA based probe for Hg(II) based on thymine-Hg(II)-thymine interaction and enrichment via magnetized graphene oxide."Microchim Acta. 2018 Mar;185(3):1-7 32. [IF=5.162] Shengxue Hu et al."Preparation of biocompatible wound dressings with long-term antimicrobial activity through covalent bonding of antibiotic agents to natural polymers."Int J Biol Macromol. 2019 Feb;123:1320 33. [IF=4.316] Dan Cheng et al."A Non-Enzymatic Electrochemical Sensing Platform Based on Hemin@MOF Composites for Detecting Hydrogen Peroxide and DNA."J Electrochem Soc. 2018 Dec;165(16):B885 34. [IF=4.316] Dan Cheng et al."An Electrochemical DNA Sensing Platform Using Carboxyl Functionalized Graphene as the Electrode Modified Material."J Electrochem Soc. 2017 Apr;164(6):H345 35. [IF=4.142] He Baoshan et al."Novel electrochemical aptasensor for ultrasensitive detection of sulfadimidine based on covalently linked multi-walled carbon nanotubes and in situ synthesized gold nanoparticle composites."Anal Bioanal Chem. 2018 May;410(12):2901-2910 36. [IF=4.094] Yating Wang et al."Synthesis of PGMA/AuNPs amplification platform for the facile detection of tumor markers."Mater Chem Phys. 2016 Nov;183:534 37. [IF=2.896] Linlin Yang et al."Single-walled carbon nanotubes–carboxyl-functionalized graphene oxide-based electrochemical DNA biosensor for thermolabile hemolysin gene detection."Anal Methods-Uk. 2015 Jun;7(12):5303-5310 38. [IF=2.896] Jing Wang et al."Electrochemical immunosensor detection of tumor markers based on a GO composite nanoprobe for signal amplification."Anal Methods-Uk. 2018 Feb;10(5):526-532 39. [IF=2.896] Bao-Shan He et al."Electrochemical aptasensor based on aptamer-complimentary strand conjugate and thionine for sensitive detection of tetracycline with multi-walled carbon nanotubes and gold nanoparticles amplification."Anal Methods-Uk. 2018 Feb;10(7):783 40. [IF=2.896] Dongcheng Yang et al."An efficient method for the synthesis of a polymer brush via click chemistry and its ultrasensitive electrochemical detection of AFP."Anal Methods-Uk. 2018 May;10(20):2390-2397 41. [IF=11.161] Ye Lili et al."Dendrimer-modified gold nanorods as a platform for combinational gene therapy and photothermal therapy of tumors."J Exp Clin Canc Res. 2021 Dec;40(1):1-16 42. [IF=10.435] Qiang Lei et al."A novel macrophage-mediated biomimetic delivery system with NIR-triggered release for prostate cancer therapy."J Nanobiotechnol. 2019 Dec;17(1):1-15 43. [IF=9.381] Xiujing Yin et al."Metabonomics analysis of drought resistance of wheat seedlings induced by β-aminobutyric acid-modified chitooligosaccharide derivative."Carbohyd Polym. 2021 Nov;272:118437 44. [IF=7.79] Zhigang Fang et al."Sgc8 aptamer targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia."Nanoscale. 2019 Dec;11(47):23000-23012 45. [IF=7.711] Rong Zhang et al."A Disposable Printed Liquid Gate Graphene Field Effect Transistor for a Salivary Cortisol Test."Acs Sensors. 2021;6(8):3024–3031 46. [IF=6.953] Zhang Man et al."An in situ catechol functionalized ε-polylysine/polyacrylamide hydrogel formed by hydrogen bonding recombination with high mechanical property for hemostasis."Int J Biol Macromol. 2021 Nov;191:714 47. [IF=6.953] Sidi Li et al."Metal-crosslinked ɛ-poly-L-lysine tissue adhesives with high adhesive performance: Inspiration from mussel adhesive environment."Int J Biol Macromol. 2020 Jun;153:1251 48. [IF=5.443] Wei Jie et al."Evaluation of Silk Fibroin-RGD-Stem Cell Factor Scaffold Effect on Adhesion, Migration, and Proliferation of Stem Cells of Apical Papilla."Stem Cells Int. 2021;2021:6612324 49. [IF=5.162] Zefeng Lin et al."Biofunctions of antimicrobial peptide-conjugated alginate/hyaluronic acid/collagen wound dressings promote wound healing of a mixed-bacteria-infected wound."Int J Biol Macromol. 2019 Nov;140:330 50. [IF=5.162] Mou Zhou et al."Development of nanosilver doped carboxymethyl chitosan-polyamideamine alginate composite dressing for wound treatment."Int J Biol Macromol. 2021 Jan;166:1335 51. [IF=5.03] Delu Zhao et al."Effect of altering photocrosslinking conditions on the physical properties of alginate gels and the survival of photoencapsulated cells."Polym Degrad Stabil. 2020 Sep;179:109297 52. [IF=4.952] Yanan Xu et al."Assembly of zein–polyphenol conjugates via carbodiimide method: Evaluation of physicochemical and functional properties."Lwt Food Sci Technol. 2022 Jan;154:112708 53. [IF=4.598] Yuan Zhong et al."Mussel-inspired hydrogels as tissue adhesives for hemostasis with fast-forming and self-healing properties."Eur Polym J. 2021 Apr;148:110361 54. [IF=4.539] Dong-xue Ren et al."pH/redox dual response nanoparticles with poly-γ-glutamic acid for enhanced intracellular drug delivery."Colloid Surface A. 2019 Sep;577:412 55. [IF=4.367] Sidi Li et al."Environment-Dependent Adhesive Behaviors of Mussel-Inspired Coordinate-Crosslinked Bioadhesives."Macromol Mater Eng. 2020 Jan;305(1):1900620 56. [IF=4.24] Hongsu Wang et al."Composite chitosan films prepared using nisin and Perilla frutescense essential oil and their use to extend strawberry shelf life."Food Biosci. 2021 Jun;41:101037 57. [IF=4.098] Shujuan Chen et al."A magnetic phosphorescence molecularly imprinted polymers probe based on manganese-doped ZnS quantum dots for rapid detection of trace norfloxacin residual in food."Spectrochim Acta A. 2021 May;253:119577 58. [IF=3.978] Jingyang Zhao et al."Self-assembled pH-responsive polymeric nanoparticles based on lignin-histidine conjugate with small particle size for efficient delivery of anti-tumor drugs."Biochem Eng J. 2020 Apr;156:107526 59. [IF=3.517] Fangfang Xie et al."Effect of a new modified polyamidoamine dendrimer biomimetic system on the mineralization of type I collagen fibrils: an in vitro study."Journal Of Biomaterials Science-Polymer Edition. 2021 Oct 03 60. [IF=3.361] Ying Liang et al."A label-free immunosensor based on PHEMA/graphene oxide nanocomposite for simultaneous electrochemical determination of alpha fetoprotein."Rsc Adv. 2019 May;9(30):17187-17193 61. [IF=3.361] Xiangyu Li et al."Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis."Rsc Adv. 2021 Jan;11(6):3567-3574 62. [IF=3.275] Haichao Zhang et al."Deterministic Lateral Displacement-Based Separation of Magnetic Beads and Its Applications of Antibody Recognition."Sensors-Basel. 2020 Jan;20(10):2846 63. [IF=1.967] Min Wei et al."A novel signal-on fluorescent aptasensor for ochratoxin A detection based on RecJf exonuclease-induced signal amplification."J Chin Chem Soc-Taip. 2020 Jul;67(7):1247-1253 64. [IF=1.415] R. Zhang et al."Total solution processable and low-cost DNA methylation sensor."J Instrum. 2021 Sep;16(09):P09021 65. [IF=3.398] Jie Liu et al."Cholesteric Liquid Crystal Photonic Hydrogel Films Immobilized with Urease Used for the Detection of Hg2+."Chemosensors. 2022 Apr;10(4):140 66. [IF=4.412] Wenyun Wang et al."Synthesis of γ-Aminobutyric Acid-Modified Chitooligosaccharide Derivative and Enhancing Salt Resistance of Wheat Seedlings."MOLECULES. 2022 Jan;27(10):3068 67. [IF=4.43] Jiahao Qu et al."Hybrid nanocomposite multinetwork hydrogel containing magnesium hydroxide nanoparticles with enhanced antibacterial activity for wound dressing applications."POLYMER. 2022 Jun;251:124902 68. [IF=4.821] Weidao Yu et al."A turn-on fluorescent aptasensor for ampicillin detection based on gold nanoparticles and CdTe QDs."Microchem J. 2022 Aug;179:107454 69. [IF=14.188] Shuqi Jiang et al."Manganese Dioxide-Based Nanocarrier Delivers Paclitaxel to Enhance Chemotherapy against Orthotopic Glioma through Hypoxia Relief."Small Methods |
N-羟基琥珀酰亚胺(N-羟基丁二酰亚胺) - 介绍
对潮湿敏感，溶于水，易溶于丙酮、醇和乙酸乙酯；微溶于氯代烃、醚、甲苯和苯。产品易结块。
最后更新：2022-10-16 17:27:00
N-羟基琥珀酰亚胺(N-羟基丁二酰亚胺) - 简介
N-羟基丁二酰亚胺（N-Hydroxysuccinimide，简称NHS）是一种有机化合物。
性质：
外观：白色结晶粉末。
溶解性：可溶于水、醇类和醚类溶剂。
用途：
1. 常作为生物化学和有机化学中的活化试剂，可以与氨基化合物或羟基化合物生成N-烷基酰亚胺或N-烷氧基酰亚胺。
2. 在酶学研究中，可用于交联酶和载体的制备。
制法：
常见制法是通过琼脂糖合成，将琼脂糖和次氯酸钠反应得到次氯酸琼脂糖，然后将次氯酸琼脂糖与氨基丁二酸反应，得到产物。
安全信息：
1. 具有一定的刺激性，接触皮肤、眼睛或吸入可能引起不适，应注意避免直接接触。
2. 使用时应戴上适当的防护设备，如手套、护目镜和防护服。
3. 存放时应避免与有机物和可燃物接触，远离明火和高温。
4. 在使用和处理过程中，应遵守实验室的安全操作规程。
最后更新：2024-04-10 11:14:41
供应商列表
主打产品
产品名: N-羟基丁二酰亚胺(HOSU) 询盘CAS: 6066-82-6
产地: 江苏
电话: 0512-68311833
手机: 程吴昊13962195826 马婉莹13771732418 殷斌18306219922
电子邮件: wuhao@highfine.com
mawy@highfine.com
merry@highfine.com
QQ: 4006286883
产品描述: 产品编号：A01050
外观：白色结晶粉末
标准含量：99% HPLC
主打产品
产品名: N-羟基丁二酰亚胺(HOSU) 询盘CAS: 6066-82-6
产地: 江苏
电话: 0512-68311833
手机: 程吴昊13962195826 马婉莹13771732418 殷斌18306219922
电子邮件: wuhao@highfine.com
mawy@highfine.com
merry@highfine.com
QQ: 4006286883
产品描述: 产品编号：A01050
外观：白色结晶粉末
标准含量：99% HPLC
N-羟基琥珀酰亚胺(N-羟基丁二酰亚胺)的上游原料
N-羟基琥珀酰亚胺(N-羟基丁二酰亚胺)的下游产品
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！