中文名 | N-羟基丁二酰亚胺 |
英文名 | N-Hydroxy succinimide |
别名 | 羟基丁二酰亚胺 N-羟基丁亚二酰胺 N-羟基琥珀酰亚胺 N-羟基丁二酰亚胺 N-N-羟基琥珀酰亚胺 N-羟基丁二酰亚胺(+4℃) N-羟基丁二酰亚胺(HOSu) N-羟基琥珀酰亚胺 (HOSU) N-羟基琥珀酰亚胺(N-羟基丁二酰亚胺) N-羟基丁二酰亚胺(N-羟基琥珀酰亚胺) N-羟基琥珀酰亚胺(HOSU)|N-羟基丁二酰亚胺 |
英文别名 | NHS HOSu HONSU NHS OR HONSU N-HYDROXYSUCCINIMDE 1-Hydroxysuccinimide N-HYDROXYSUCCINIMIDE N-Hydroxysuccinimide N-Hydroxy succinimide NHS N-HYDROXYSUCCINIMIDE, N-Hydroxysuccinimide (HOSu) 1-hydroxy-5-pyrrolidinedione 5-Pyrrolidinedione,1-hydroxy-2 N-HYDROXY-2,5-PYRROLIDINEDIONE 1-hydroxypyrrolidine-2,5-dione 1-Hydroxy-2,5-pyrrolidinedione 1-Hydroxy-2,5-pyrrolidine-dione N-HYDROXYSUCCINIMIDE POLYMER-BOUND N-Hydroxysuccinimide POLYMER-BOUND HOSu~1-Hydroxy-2,5-pyrrolidinedione |
CAS | 6066-82-6 |
EINECS | 228-001-3 |
化学式 | C4H5NO3 |
分子量 | 115.09 |
InChI | InChI=1/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2 |
InChIKey | NQTADLQHYWFPDB-UHFFFAOYSA-N |
密度 | 1.4769 (rough estimate) |
熔点 | 95-98°C(lit.) |
沸点 | 215.33°C (rough estimate) |
闪点 | 112.5°C |
水溶性 | SOLUBLE |
蒸汽压 | 0Pa at 25℃ |
溶解度 | DMSO (可溶) 、甲醇 (微溶) |
折射率 | 1.4080 (estimate) |
酸度系数 | 7.81±0.20(Predicted) |
PH值 | 5-7 (50g/l, H2O, 20℃) |
存储条件 | Store at +2°C to +8°C. |
稳定性 | 稳定。与强氧化剂、酰氯、酸酐、强碱不相容。防潮。 |
敏感性 | Hygroscopic |
外观 | 液体或固体 |
颜色 | Clear yellow-brown to brown |
BRN | 113913 |
物化性质 | 白色结晶体。熔点99-100℃。 |
MDL号 | MFCD00005516 |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
WGK Germany | 3 |
TSCA | Yes |
海关编号 | 29251995 |
Hazard Note | Irritant |
上游原料 | 丁二酸酐 盐酸羟胺 |
下游产品 | 咪达普利 胍立莫司 |
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N-羟基丁二酰亚胺(N-Hydroxysuccinimide,简称NHS)是一种有机化合物。
性质:
外观:白色结晶粉末。
溶解性:可溶于水、醇类和醚类溶剂。
用途:
1. 常作为生物化学和有机化学中的活化试剂,可以与氨基化合物或羟基化合物生成N-烷基酰亚胺或N-烷氧基酰亚胺。
2. 在酶学研究中,可用于交联酶和载体的制备。
制法:
常见制法是通过琼脂糖合成,将琼脂糖和次氯酸钠反应得到次氯酸琼脂糖,然后将次氯酸琼脂糖与氨基丁二酸反应,得到产物。
安全信息:
1. 具有一定的刺激性,接触皮肤、眼睛或吸入可能引起不适,应注意避免直接接触。
2. 使用时应戴上适当的防护设备,如手套、护目镜和防护服。
3. 存放时应避免与有机物和可燃物接触,远离明火和高温。
4. 在使用和处理过程中,应遵守实验室的安全操作规程。
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