中文名 | NSC232003 |
英文名 | NSC232003 |
别名 | 化合物NSC232003 UHRF1抑制剂(NSC232003) |
英文别名 | NSC232003 1905453-18-0 |
CAS | 1905453-18-0 |
化学式 | C6H7N3O3 |
分子量 | 169.14 |
溶解度 | H2O: 17 mg/mL (需要超声波和加温) |
存储条件 | -20℃ |
体外研究 | NSC232003, a uracil derivative freely available by the NCI/DTP repository, provides a versatile lead for developing highly potent and cell-permeable UHRF1 inhibitors that will enable dissection of DNA methylation inheritance. NSC232003 is indeed an effective DNA methylation inhibitor and indicate that this particular nucleotide scaffold could provide a versatile basis for the design of potent UHRF1 inhibitors. NSC232003 is predicted to be partially deprotonated at pH 7, as the pK a of the more acidic imide nitrogen of the pyrimidine ring is a value of 7.6 in NSC232003. The DNMT1/UHRF1 interactions are significantly reduced after 4 h of incubation of U251 glioma cells with the most potent compound NSC232003, showing a 50% interaction inhibition at 15 μM as well as induction of global DNA cytosine demethylation as measured by ELISA. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 5.912 ml | 29.562 ml | 59.123 ml |
5 mM | 1.182 ml | 5.912 ml | 11.825 ml |
10 mM | 0.591 ml | 2.956 ml | 5.912 ml |
5 mM | 0.118 ml | 0.591 ml | 1.182 ml |
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