中文名 | 1-(叔丁基)-3-(6-(2,6-二氯苯基)-2-((4-(二乙基氨基)丁基)氨基)吡啶并[2,3-d]嘧啶-7-基)脲 |
英文名 | PD 161570 |
别名 | 化合物PD 161570 1-(叔丁基)-3-(6-(2,6-二氯苯基)-2-((4-(二乙基氨基)丁基)氨基)吡啶并[2,3-D]嘧啶-7-基)脲 1-(叔丁基)-3-(6-(2,6-二氯苯基)-2-((4-(二乙基氨基)丁基)氨基)吡啶并[2,3-d]嘧啶-7-基)脲 |
英文别名 | PD-161570 PD 161570 PF-1480232 PD-161570 PF-1480232 1-(tert-Butyl)-3-(6-(2,6-dichlorophenyl)-2-((4-(diethylamino)butyl)amino)pyrido[2,3-d]pyrimidi 1-Tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylaMino-butylaMino)pyrido[2,3-d]pyriMidin-7-yl]urea N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea |
CAS | 192705-80-9 |
化学式 | C26H35Cl2N7O |
分子量 | 532.51 |
熔点 | 215-230?C |
溶解度 | DMSO: >10 mg/mL |
存储条件 | Store at RT |
外观 | 粉末 |
颜色 | white to off-white |
MDL号 | MFCD16618403 |
体外研究 | PD-161570 (Compound 6c; 0.1-1 µM; 1-8 days; VSMCs) treatment inhibits PDGF-stimulated vascular smooth muscle cell proliferation in a dose dependent fashion with an IC 50 of 0.3 µM on day 8. PD-161570 suppresses constitutive phosphorylation of the FGF-1 receptor in both human ovarian carcinoma cells (A 121(p) ) and Sf9 insect cells overexpressing the human FGF-1 receptor and blocked the growth of A 121(p) cells in culture. PD-161570 can potently inhibit basic fibroblast growth factor (bFGF)-mediated angiogenesis. Cell Proliferation Assay Cell Line: Vascular smooth muscles cells (VSMCs) Concentration: 0.1 µM, 0.3 µM, 1 µM Incubation Time: 1 day, 3 days, 6 days, 8 days Result: Inhibited VSMC proliferation in a dose dependent fashion with an IC 50 of 0.3 µM at day 8. |
危险品标志 | T - 有毒物品 |
风险术语 | R25 - 吞食有毒。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 |
危险品运输编号 | UN 2811 6.1 / PGIII |
WGK Germany | 3 |
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