中文名 | CCT007093 |
英文名 | CCT007093 |
别名 | PPM1D抑制剂(CCT007093) (2E,5E)-2,5-二(2-噻吩基亚甲基)环戊酮 |
英文别名 | CCTOO7093 CCT007093 2,5-Bis(2-thienylmethylene)-cyclopentanone (2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone 2,5-bis(2-thienylMethylene)-, (E,E)-Cyclopentanone Cyclopentanone, 2,5-bis(2-thienylMethylene)-, (E,E)- (2E,5E)-2,5-Bis(thiophen-2-ylmethylene)cyclopentanone (2E,5E)-2,5-Bis(2-thienylmethylene)cyclopentanone CCT007093 |
CAS | 176957-55-4 |
化学式 | C15H12OS2 |
分子量 | 272.39 |
熔点 | 222-223℃ |
溶解度 | DMSO: >3 mg/mL |
存储条件 | 2-8°C |
敏感性 | Light Sensitive |
外观 | 粉末,黄色 |
体外研究 | CCT007093 (25 or 50 µM, 8 h) significantly increases the phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159, and the phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) are also up-regulated in transfected HEK293T cell line. CCT007093 shows specificity for MCF-7 cells, reducing viability by 40% after 2 days with no observable effect on the growth of HeLa cells. CCT007093 induces P38 phosphorylation at 4 h post exposure in MCF-7 cells (sensitive to PPM1D inhibition), and does not induce P38 phosphorylation in HeLa cells (relatively resistant to PPM1D inhibition). Western Blot Analysis Cell Line: HEK293T cell line. Concentration: 25 or 50 µM. Incubation Time: 8 h. Result: The phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159 were all significantly increased [1] . The phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) were also up-regulated [1] . |
体内研究 | CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy. Animal Model: Wild-type mice. Dosage: 3.2 and 6.4 mg/kg. Administration: Injected intraperitoneally 4 times (mice were sacrificed at 36 h post-PH). Result: Significantly improved survival in mice following major hepatectomy (80% hepatectomy). The level of PCNA was also significantly increased in the liver of CCT007093-treated mice at 36h, 48h and 72h post-PH. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | 26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.671 ml | 18.356 ml | 36.713 ml |
5 mM | 0.734 ml | 3.671 ml | 7.343 ml |
10 mM | 0.367 ml | 1.836 ml | 3.671 ml |
5 mM | 0.073 ml | 0.367 ml | 0.734 ml |
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