中文名 | 木聚硫钠 |
英文名 | Pentosan |
别名 | 木聚硫钠 化合物 T12420L |
英文别名 | Cb 8061 Pentosan Hemoclar Cartrophen Hemoclar [french] beta-D-Xylan, (1-4), 2,3-bis(hydrogen sulfate), sodium salt 4-o-Methyl-alpha-D-glucurono-beta-D-xylan, hydrogen sulfate, sodium salt |
CAS | 140207-93-8 |
体外研究 | Pentosan Polysulfate Sodium has been shown to inhibit HIV-1 activity with an ED 50 of 0.19 μg/mL in MT-4 cells. It inhibits HIV-1 antigen expression in HUT-78 cells at an ED 50 of 0.02 μg/mL, and complete inhibition of HIV-1 antigen expression is obtained at a concentration of 4.0 μg/mL. Pentosan Polysulfate Sodium suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production. |
体内研究 | Pentosan Polysulfate Sodium has been shown to decreases interstitial inflammation and glomerulosclerosis in 5/6 nephrectomized rats. Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan Polysulfate Sodium also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys. |
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