R-2-羟基戊二酸_化工百科

中文名	R-2-羟基戊二酸
英文名	2-hydroxypentanedioic acid
别名	R-2-羟基戊二酸
英文别名	R-2-HYDROXYGLUTARATE D--Hydroxyglutaric Acid D-2-Hydroxyglutaric acid (R)-2-Hydroxyglutaric acid 2-hydroxypentanedioic acid D-alpha-Hydroxyglutaric acid (R)-alpha-Hydroxyglutaric acid Pentanedioic acid, 2-hydroxy-, (2R)-
CAS	13095-47-1
EINECS	231-158-0
化学式	C5H8O5
分子量	148.11
InChI	InChI=1/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/t3-/m1/s1
密度	1.508±0.06 g/cm3(Predicted)
沸点	394.2±27.0 °C(Predicted)
闪点	206.4°C
蒸汽压	7.55E-08mmHg at 25°C
折射率	1.519
酸度系数	3.67±0.10(Predicted)
存储条件	Sealed in dry,Store in freezer, under -20°C
体外研究	D-α-Hydroxyglutaric acid ((R)-2-hydroxyglutarate) accumulates in human cancers carrying neomorphic mutations in the isocitrate dehydrogenase (IDH) 1 and 2 genes. A partial inhibition of KDM7A toward both H3K9me2 and H3K27me2 peptides is observed in the presence of 50 mM D-2-HG and 100 μM α-ketoglutarate (α-KG). Addition of 300 μM α-KG is capable of reversing the inhibition of Caenorhabditis elegans KDM7A (CeKDM7A) by 50 mM D-2-HG, indicating that D-2-HG is a weak competitive inhibitor against α-KG toward the CeKDM7A demethylase. D-α-Hydroxyglutaric acid is a weak inhibitor of TET hydroxylases. In the presence of 0.1 mM of α-KG, addition of 10 mM D-α-Hydroxyglutaric acid results in a partial (33%) inhibition of TET2 and addition of 50 mM D-α-Hydroxyglutaric acid results in more inhibition (83%) of TET2. D-α-Hydroxyglutaric acid exhibits a less pronounced inhibitory effect toward TET1.
体内研究	D-α-Hydroxyglutaric acid strongly inhibits glucose utilization, CO 2 production and the respiratory chain in rat cerebral cortex and human skeletal muscle, as well as in submitochondrial particles from bovine heart, suggesting an impairment of the aerobic metabolism. D-α-Hydroxyglutaric acid has also been proposed as an endogenous excitotoxic organic acid because it significantly decreased cell viability in neuronal cultures from chick embryo telencephalons and from neonatal rat hippocampus through stimulation of specific NMDA glutamate receptors. D-α-Hydroxyglutaric acid (0.01-1 mM) significantly increases chemiluminescence and thiobarbituric acid-reactive substances (TBA-RS) and decreased total antioxidant reactivity (TAR) values in the cortical supernatants in 30-day-old-rats.

R-2-羟基戊二酸 - 简介

R-2-羟基戊二酸（R-2-hydroxyadipic acid）是一种有机化合物。它是一种白色结晶固体，可溶于水。

R-2-羟基戊二酸主要用于合成聚酯树脂和聚酯弹性体，具有优异的热稳定性和机械性能。

制备R-2-羟基戊二酸的方法主要有以下几种：
通过己二酸的氢化反应合成，己二酸与氢气在催化剂作用下发生氢化反应，生成R-2-羟基戊二酸。
通过环氧己烷的环开反应和氧化裂解反应合成，先将环氧己烷与水在碱性条件下进行环开反应生成氢氧化己酸钠，然后在酸性条件下进行氧化裂解反应，最终得到R-2-羟基戊二酸。

R-2-羟基戊二酸的安全信息：它属于一种相对安全的化合物，一般无毒性但仍需避免吸入粉尘或接触皮肤和眼睛。在操作时，应佩戴适当的防护设备，如手套、眼镜和口罩，避免直接接触和吸入。在储存过程中，应将其保存在干燥、通风良好的场所，并避免与氧化剂或强酸接触。如有必要，还应遵循当地的安全操作规程和应急措施。

最后更新：2024-04-09 21:54:55

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CAS: 13095-47-1
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产品名: (R)-2-Hydroxyglutarate 去供应商网站查看询盘
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