Rostafuroxin_化工百科

中文名	ROSTAFUROXIN
英文名	(3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol
别名	化合物ROSTAFUROXIN (3Β,?5Β,?14Β)?-?21,23-环氧-24-降胆固醇-20,22-二烯-3,14,17-三醇
英文别名	PST2238 ROSTAFUROXIN Rostafuroxin Rostafuroxin PST2284 Rostafuroxin (PST-2238) (3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol (3beta,5beta,14beta)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol Rostafuroxin (PST 2238) (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol
CAS	156722-18-8
化学式	C23H34O4
分子量	374.51
密度	1.226±0.06 g/cm3(Predicted)
沸点	451.3±45.0 °C(Predicted)
酸度系数	14.02±0.70(Predicted)
存储条件	Sealed in dry,Store in freezer, under -20°C
体外研究	Rostafuroxin (PST 2238) competitively inhibits Ouabain (HY-B0542) binding and signaling. Rostafuroxin antagonizes the molecularand functional effects of Ouabain by reversing the ouabain-induced, Src-dependent Na + ,K + -ATPase phosphorylation and activation. Rostafuroxin (0.125-128 μM; for 24 h post treatment) has less than 20% reduction in cell viability in A549 cells and HSAEC. Rostafuroxin inhibits the expression of RSV-GFP in HSAEC (IC 50 =1.8 μM) and A549 cells (IC 50 =14.8 μM). Rostafuroxin displaced [ 3 H]Ouabain from the dog kidney Na + ,K + -ATPase receptor (IC50=1.5 nM), is devoid of cardiac inotropic activity in isolated guinea pig atria, and shows no affinity up to 10 -4 M with general (R1, R2, a1, a2, A1, A2, M1, M2, H1, H2, 5-HT1, 5-HT2, Ca2+ channels, TXA2/PGH2, PAF, GABAA, GABAB, DA-NE-5-HT uptake, glutammate,glycine, benzodiazepine) and hormonal (estrogenic, progestinic, androgenic, mineralcorticoid) receptors.
体内研究	Rostafuroxin (PST 2238; 1 mg/kg/day; gavage; for 3 weeks) decreases SBP and improves acetylcholine-induced relaxation. Animal Model: Male 7-week-old Wistar rats Dosage: 1 mg/kg Administration: Gavage; daily; for 3 weeks Result: Decreased SBP, improved acetylcholine-induced relaxation via enhanced nitric oxide synthesis and bioavailability, decreased superoxide anion generation from NAD(P)H oxidase and cyclooxygenase-2 and reduced cytoplasmic tyrosine kinase Src phosphorylation.

Rostafuroxin - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.67 ml	13.351 ml	26.702 ml
5 mM	0.534 ml	2.67 ml	5.34 ml
10 mM	0.267 ml	1.335 ml	2.67 ml
5 mM	0.053 ml	0.267 ml	0.534 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

产品名: Rostafuroxin 去供应商网站查看询盘
CAS: 156722-18-8
产地: 北京
包装: 1mg /瓶
规格: IR2610-1mg
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上海吉至生化科技有限公司

现货供应

产品名: ROSTAFUROXIN 去供应商网站查看询盘
CAS: 156722-18-8
产地: 中国上海
包装: 100mg
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上海麦克林生化科技股份有限公司

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产品名: Rostafuroxin 去供应商网站查看询盘
CAS: 156722-18-8
产地: 上海
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价格: 10mg-896,50mg-3881
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上海源叶生物科技有限公司

产品名: ROSTAFUROXIN 去供应商网站查看询盘
CAS: 156722-18-8
产地: 上海
规格: 96%
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