S18-000003_化工百科

中文名	S18-000003
英文名	S18-000003
别名	化合物S18-000003
英文别名	S18-000003 Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl-
CAS	2068119-11-7
化学式	C26H25F3N2O4S
分子量	518.55
密度	1.358±0.06 g/cm3(Predicted)
沸点	746.1±60.0 °C(Predicted)
溶解度	溶于DMSO
酸度系数	11.82±0.70(Predicted)
存储条件	-20℃
靶点	RORγt,29 nM
体外研究	S18-000003 inhibits human and mouse RORγt-dependent transactivation, with IC 50 s of 0.029 and 0.34 μM respectively in cell-based GAL4 promoter reporter assays. S18-000003 (0.003-0.3 μM; 7 d) dose-dependently inhibits Th17 cell differentiation from human naive CD4 + T cells, with an IC 50 of 0.024 μM. S18-000003 (0.1-3 μM; 4 d) inhibits the differentiation of mouse Th17 cells from splenic naive CD4 + T cells, with an IC 50 of 0.20 μM. S18-000003 (0.03-1 μM; 3 d) reduces the IL-17 production in human PBMCs in a dose-dependent manner, and does not inhibit either the production of other cytokines (IL-2, IL-4, IL-10 and IFN-g) or cell proliferation. S18-000003 (0.1-3 μM; 3 d) reduces IL-17 and IL-22 production in PBMCs from psoriatic mice in a dose-dependent manner.
体内研究	S18-000003 (30-100 mg/kg; p.o.) inhibits IL-17 production in the skin of IL-23-treated mice in a dose-dependent manner. S18-000003 (0.1-8%; 100mL; topically administration once daily for 14 days) ameliorates psoriasis-like lesions in TPA-induced K14.Stat3C transgenic mice, and has little impact on the thymus. S18-000003 (0.5 mg/kg; i.v.) exhibits the half-life (3.2 h), AUC (1930 ng•h/mL), CL tot (4.33 mL/min/kg) and Vd ss in rats. S18-000003 (1 mg/kg; p.o.) exhibits the oral bioavailability (54.5%), C max (185 ng/mL), AUC (2110 ng•h/mL) and T max (4 h) in rats.
参考资料展开查看	1: Sasaki Y, Odan M, Yamamoto S, Kida S, Ueyama A, Shimizu M, Haruna T, Watanabe A, Okuno T. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3549-3553. doi: 10.1016/j.bmcl.2018.09.032. Epub 2018 Sep 27. PubMed PMID: 30301676.[2]. Imura C, et, al. A novel RORγt inhibitor is a potential therapeutic agent for the topical treatment of psoriasis with low risk of thymic aberrations. J Dermatol Sci. 2019 Mar;93(3):176-185.

S18-000003 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.928 ml	9.642 ml	19.285 ml
5 mM	0.386 ml	1.928 ml	3.857 ml
10 mM	0.193 ml	0.964 ml	1.928 ml
5 mM	0.039 ml	0.193 ml	0.386 ml

最后更新：2024-01-02 23:10:35

S18-000003 - 简介

S18-000003是一个化学物质的编码，它是指某种特定的化合物或化学品。

最后更新：2024-04-09 15:16:57

北京索莱宝科技有限公司

现货供应

产品名: S18-000003 去供应商网站查看询盘
CAS: 2068119-11-7
产地: 北京
包装: 盒
规格: IS3240-5mg,5mg
价格: 电话、微信、QQ、邮件
库存: 现询
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上海吉至生化科技有限公司

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产品名: S18-000003 去供应商网站查看询盘
CAS: 2068119-11-7
产地: 中国上海
包装: 5mg
规格: 99%
价格: 3498.00
库存: 现货
电话: 400-900-4166
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产品描述: 中文名：S18-000003 英文名:S18-000003 CAS:2068119-11-7 规格:99% 产地:中国上海

上海麦克林生化科技股份有限公司

现货供应

产品名: S18-000003 去供应商网站查看询盘
CAS: 2068119-11-7
产地: 上海
规格: S936917
价格: 1mg-1251,5mg-5958
库存: 15天内发货
电话: 13816333479/17821173903
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上海源叶生物科技有限公司

现货供应

产品名: S18-000003 去供应商网站查看询盘
CAS: 2068119-11-7
产地: 上海
规格: 98%
价格: 5mg 960,10mg 1600,25mg 3200,100mg 8640
库存: 现货
电话: 18301782025
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