Sulfopin
Sulfopin(2-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide)
CAS: 2451481-08-4
化学式: C11H20ClNO3S
| 中文名 | Sulfopin |
| 英文名 | 2-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide |
| 别名 | 化合物SULFOPIN |
| 英文别名 | sulfopin Sulfopin 1-dioxido-3-thienyl)- 2-dimethylpropyl)-N-(tetrahydro-1 2-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- |
| CAS | 2451481-08-4 |
| 化学式 | C11H20ClNO3S |
| 分子量 | 281.8 |
| 密度 | 1.23±0.1 g/cm3(Predicted) |
| 沸点 | 455.5±45.0 °C(Predicted) |
| 溶解度 | 溶于DMSO (>25 mg/ml) |
| 酸度系数 | -1.36±0.20(Predicted) |
| 存储条件 | -20°C |
| 稳定性 | 从提供的购买之日起稳定2年。DMSO中的溶液可以在-20 °C下储存长达1个月。 |
| 外观 | 固体 |
| 颜色 | Off-white |
| 产品用途 | Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Sulfopin is highly selective, as validated by two independent chemoproteomics methods, achieves potent cellular and in vivo target engagement and phenocopies Pin1 genetic knockout. Sulfopin induced downregulation of c-Myc target genes, reduced tumor progression and conferred survival benefit in murine and zebrafish models of MYCN-driven neuroblastoma, and in a murine model of pancreatic cancer. Sulfopin is a chemical probe suitable for assessment of Pin1-dependent pharmacology in cells and in vivo, and that Pin1 warrants further investigation as a potential cancer drug target. |
Sulfopin - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
| 10 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
最后更新：2024-01-02 23:10:35
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