中文名 | Xeruborbactam |
英文名 | Benzo[e]cycloprop[c][1,2]oxaborin-4-carboxylic acid, 5-fluoro-1,1a,2,7b-tetrahydro-2-hydroxy-, (1aR,7bS)- |
别名 | 化合物 T12604 |
英文别名 | QPX7728 Xeruborbactam Benzo[e]cycloprop[c][1,2]oxaborin-4-carboxylic acid, 5-fluoro-1,1a,2,7b-tetrahydro-2-hydroxy-, (1aR,7bS)- |
CAS | 2170834-63-4 |
化学式 | C10H8BFO4 |
溶解度 | 溶于DMSO |
存储条件 | -20 ℃, dark |
产品用途 | QPX7728 is an ultrabroad-spectrum inhibitor of serine and metallo-β-lactamases. This compound displays a remarkably broad spectrum of inhibition, including class B and class D enzymes, and is little affected by porin modifications and efflux. QPX7728 is a promising agent for use in combination with a β-lactam antibiotic for the treatment of a wide range of multidrug resistant Gram-negative bacterial infections, by both intravenous and oral administration. |
参考资料 展开查看 | 1. Lomovskaya O, et al, The Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultra-Broad-Spectrum Beta-lactamase Inhibitor of Serine and Metallo Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Antimicrob Agents Chemother. 2020 Mar 30. pii: AAC.00552-20. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.505 ml | 22.525 ml | 45.049 ml |
5 mM | 0.901 ml | 4.505 ml | 9.01 ml |
10 mM | 0.45 ml | 2.252 ml | 4.505 ml |
5 mM | 0.09 ml | 0.45 ml | 0.901 ml |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!