中文名 | YS-49 |
英文名 | YS-49 |
别名 | 化合物YS-49 1,2,3,4-四氢-1-(1-萘基甲基)-6,7-异喹啉二醇氢溴酸盐 |
英文别名 | YS49 YS 49 YS-49 CS-884 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate |
CAS | 132836-42-1 |
化学式 | C20H20BrNO2 |
分子量 | 386.2823 |
溶解度 | H2O: >10 mg/mL |
存储条件 | 2-8°C |
外观 | 固体 |
体外研究 | YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μM and 30 μM, respectively. YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level. Cell Viability Assay Cell Line: RAVSMC and RAW 264.7 cells Concentration: 10 μΜ, 30 μΜ and 100 μΜ (RAVSMC cells); 1 μΜ, 10 μΜ and 100 μM (RAW 264.7 cells) Incubation Time: 18 hours Result: Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively. Western Blot Analysis Cell Line: RAVSMC and RAW 264.7 cells Concentration: 10 μΜ, 30 μΜ and 100 μΜ Incubation Time: 18 hours Result: Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ. |
体内研究 | YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM. Animal Model: Male Sprague Dawley rats (250-300 g) Dosage: 5 mg/kg Administration: Intraperitoneal injection; 8 hours Result: Serum NOx levels were significantly reduced. |
危险品标志 | Xn - 有害物品 N - 危害环境的物品 |
风险术语 | R22 - 吞食有害。 R50 - 对水生生物有极高毒性。 |
安全术语 | 61 - 避免释放至环境中。参考特别说明/安全数据说明书。 |
危险品运输编号 | UN 3077 9 / PGIII |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.473 ml | 12.367 ml | 24.734 ml |
5 mM | 0.495 ml | 2.473 ml | 4.947 ml |
10 mM | 0.247 ml | 1.237 ml | 2.473 ml |
5 mM | 0.049 ml | 0.247 ml | 0.495 ml |
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