中文名 | 山奈酚 |
英文名 | Kaempferol |
别名 | 山柰素 山奈酚 山柰酚 山柰黄酮醇 四羟基黄酮 百蕊草素Ⅲ 山柰酚-3 纳米脂质体山奈酚 山奈酚, 来源于槐角 山柰酚(分析标准品) 山柰酚-3 山柰黄酮醇 山柰酚标准品,山柰酚对照品 山奈酚(莰菲醇,百蕊草素Ⅲ,山柰酚-3,山柰黄酮醇,四羟基黄酮 ) |
英文别名 | c.i.75640 kampherol campherol kempferol Kaempferol kaempherol C.I. 75640 indigoyellow 5,7,4'-trihydroxyflavonol 3,5,7,4-Tetrahydroxyflavone 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on |
CAS | 520-18-3 |
EINECS | 208-287-6 |
化学式 | C15H10O6 |
分子量 | 286.24 |
InChI | InChI=1/C15H10O6/c16-7-1-2-9(10(18)3-7)13-6-12(20)15-11(19)4-8(17)5-14(15)21-13/h1-6,16-19H |
InChIKey | IYRMWMYZSQPJKC-UHFFFAOYSA-N |
密度 | 1.2981 (rough estimate) |
熔点 | 276°C |
沸点 | 348.61°C (rough estimate) |
闪点 | 240.7°C |
蒸汽压 | 6.38E-16mmHg at 25°C |
溶解度 | 乙醇: 20mg/ml |
折射率 | 1.4413 (estimate) |
酸度系数 | 6.34±0.40(Predicted) |
存储条件 | 2-8°C |
稳定性 | 在溶液中不稳定 |
外观 | 粉末 |
颜色 | yellow |
Merck | 14,5274 |
BRN | 304401 |
物化性质 | 黄色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于山奈根茎,槐角,茶叶,西兰花,葡萄柚。 |
MDL号 | MFCD00016938 |
危险品标志 | Xi - 刺激性物品 T - 有毒物品 |
风险术语 | R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 R68 - 可能有不可逆后果的危险。 R25 - 吞食有毒。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 S36/37 - 穿戴适当的防护服和手套。 S36/37/38 - S22 - 切勿吸入粉尘。 |
危险品运输编号 | 2811 |
WGK Germany | - |
RTECS | LK9275200 |
FLUKA BRAND F CODES | 8-10-23 |
海关编号 | 29329990 |
下游产品 | 8-异戊烯基山奈酚 山奈酚-7-O-Β-D-葡萄糖苷 |
参考资料 展开查看 | 1. 李春娜 范冰舵 时晓娟 等. HPLC-DAD法测定蒺藜茎叶3种酸水解黄酮苷元的含量[J]. 中医药导报 2015 021(001):33-36. 2. 王志宏 周云雷 彭胜 等. HPLC法同时测定水解前后杜仲叶黄酮苷元的含量[J]. 应用化工 2014 000(005):950-953. 3. 吴皓东 李燕 郝宇薇 等. HPLC法对唇香草中山奈酚的含量测定[J]. 新疆医科大学学报 2017(09):20-22. 4. 陈亚蓝 王雪青 李月娇 宋文军 王素英.不同方法提取的板栗花黄酮对Hela细胞生长的影响[J].天然产物研究与开发 2016 28(08):1279-1283. 5. 张芳 石任兵 权建野 等. 不同生理状态下银荷方药物制备物黄酮类成分的质量表征特性研究[J]. 北京中医药大学学报 2017 40(004):322-327. 6. HOU Yaxue WEI Shenghua XU Mei 等. 厚裂凤仙花总黄酮提取工艺研究[J]. 贵州科学 2019 037(003):17-21. 7. 刘伟 南光明 李紫薇 等. 响应面法优化新疆若羌大枣总黄酮提取工艺及抗氧化活性[J]. 食品科学 2012(22):123-126. 8. 丁燕, 王枫琦, 张开梅,等. 基于QSAR模型的食品谱效关系研究:以植物黄酮为例[J]. 中国食品学报, 2018. 9. 盛节英, 周洪雷, 周倩,等. 基于UPLC-Q-Exactive Orbitrap-MS分析宣木瓜饮片化学成分[J]. 中草药, 2018, 49(20):62-68. 10. 孙浩洋, 耿璐璐, 游景水,等. 巴西蜂胶高效液相色谱指纹图谱研究[J]. 营养学报, 2016, 38(005):503-505. 11. 罗亦琨, 郑艳秋, 何昱. 谷红注射液中总多酚的含量测定[J]. 浙江中医药大学学报, 2014(7):889-893. 12. 刘海彬, 张炜, 陈元涛,等. 高效液相色谱法同时测定枸杞中槲皮素、山柰酚和异鼠李素[J]. 分析试验室, 2015, 034(011):1336-1338. 13. 李春娜 范冰舵 刘洋洋 等. HPLC-DAD波长切换法同时测定青钱柳提取物中5种有效成分[J]. 辽宁中医杂志 2015(6期):1283-1285. 14. 郑成凤 潘裕添 蔡文燕 等. HPLC-UV-MS/MS法对金线莲中黄酮类组分的鉴定和测定[J]. 天然产物研究与开发 2013. 15. 郭焱. 祖卡木颗粒中8个成分的含量测定及聚类分析[J]. 中国药师, 2020, v.23(05):61-64. 16. 任强 吴昊 聂其婷 等. HPLC-DAD法同时测定苦荞麦保健品中芦丁槲皮素山奈酚含量[J]. 济宁医学院学报 2016 39(005):317-319. 17. 曹晓华 沈旭斌 程先骄 等. HPLC双波长法测定豌豆尖中槲皮素和山奈酚的含量[J]. 食品科技 2017 042(004):270-276. 18. 曹晓华 程祖锌 林兆娜 等. UPLC测定豌豆尖中槲皮素和山奈酚的含量[J]. 食品科技 2017(9):284-287. 19. 温慧萍 雷伟敏 胡华杰.不同产地柳叶蜡梅的HPLC指纹图谱研究[J].丽水学院学报 2017 39(02):61-65. 20. 周双 孙兰英 杨光 等. 不同秋果型树莓中槲皮素和山奈酚含量的测定[J]. 食品研究与开发 2019 040(022):180-183. 21. 邵金华, 何福林, 陈霞,等. 梓树根皮总黄酮分离纯化及其抑菌活性研究[J]. 食品与机械, 2017, 33(002):140-144. 22. 李程程, 左雅敏, 蒋信明,等. 水芹中6种成分同时测定及其指纹图谱建立[J]. 中成药, 2016, 38(012):2621-2625. 23. 孙兰凤, 孙倩, 穆春旭,等. 蜂蜜中7种成分含量HPLC切换波长法测定[J]. 中国公共卫生, 2013(04):142-143. 24. 王东辉, 王楼菲, 李先恩. 贵州省野生头花蓼的品质评价[J]. 中医药导报, 2018(1):22-25. 25. 史得君 程茵 崔福顺. HPLC法测定人参茎叶总黄酮[J]. 食品工业 2015(05):287-289. 26. 刘伟 刘天琦 葛豫炜 等. UPLC-UV-QDa联用系统快速分析野生樱桃李叶化学成分[J]. 食品与机械 2018 34(009):96-99 134. 27. 余春磊,袁金娥,张鹍飞,罗小娇,齐国昌,冯宗云.回归正交试验优化超声波提取大麦中4种主要黄酮物质工艺[J].食品科学,2014,35(02):51-55. 28. 余春磊, 齐国昌, 张鹍飞,等. 大麦花后四种主要黄酮物质含量的动态变化[J]. 麦类作物学报, 2014, 34(02). 29. 贾丛, 杜亚蓉, 孙坤. 沙棘总黄酮抑制肺癌A549增殖和迁移作用及机理[J]. 天然产物研究与开发, 2020(6):937-945. 30. 华梅,原晓龙,王毅,杨卫,陈剑,马惠芬,呼延丽,杨宇明,王娟.牡丹花瓣高效液相色谱指纹图谱研究[J].西部林业科学,2018,47(01):52-58. 31. 陆兰芳, 杨鹏, 王展,等. 相溶解度法研究环糊精对山奈酚的增溶作用[J]. 中国调味品, 2019, 044(006):65-69. 32. 安学瑞, 刘晓, 葛豫炜,等. 野酸梅叶酸解产物的快速分离纯化研究[J]. 伊犁师范学院学报(自然科学版), 2018, 12(04):48-51. 33. 柴瑞娟 雷金胜. Ce(NO3)3与4-香豆酸对黑曲霉合成黄酮类化合物的影响[J]. 中国稀土学报 2017(06):117-123. 34. 康莹 毛怡宁 王方方 等. UPLC-LTQ Orbitrap MS对沙棘叶化学成分的分析[J]. 中国现代中药 2018 20(11):1340-1346. 35. 汪荣斌 秦亚东 陈颖 等. 化学计量学结合指纹图谱评价不同产地青钱柳叶的质量[J]. 中药材 2018 041(004):917-921. 36. 安欣欣, 李媛媛, 战妍妃,等. 基于UPLC-Q-Exactive和HPLC对蒲公英总黄酮部位成分分析及主成分的含量测定[J]. 中药新药与临床药理, 2019, 30(01):99-105. 37. 杨希娟, 党斌, 樊明涛. 溶剂提取对青稞中不同形态多酚组成及抗氧化活性的影响[J]. 食品科学, 2018, 39(24):246-255. 38. 韩林, 杨人乙, 胡悦,等. 藜麦发酵工艺优化及活性研究[J]. 食品与机械, 2018, 34(09):212-216+221. 39. 高宁, 张秀玲, 王炬,等. 微波辅助提取老山芹黄酮、组分分析及抗氧化活性研究[J]. 食品科技, 2018, 043(010):257-265. 40. 连优优, 叶菲菲, 吕伟旗,等. 槐花药效成分含量比较相关性研究[J]. 浙江中西医结合杂志, 2018, 028(005):416-420. 41. 刘伟, 高红艳, 李紫薇,等. 野生樱桃李叶总黄酮含量测定方法比较研究[J]. 江西农业大学学报, 2016, 38(001):192-197. 42. 佚名. 高效液相色谱法同时测定青钱柳中9种指标成分的含量[J]. 天然产物研究与开发, 2017, 11(v.29):96-100. 43. 温慧萍 肖建中 雷伟敏 等. HPLC结合响应面法优化柳叶蜡梅总黄酮提取工艺及其抑菌活性研究[J]. 浙江农业学报 2018 030(002):298-306. 44. 蔡爽, 阮成江, 杜维, et al. 沙棘叶片,果肉和种子中黄酮类成分的差异[J]. 植物资源与环境学报, 2019(4). 45. 崔福顺, 史得君, 李官浩,等. 盐酸水解法制备人参茎叶黄酮苷元的工艺研究[J]. 食品科技, 2015(08):208-211. 46. 郭爽, 李庆, 何婉婉,等. 鸡冠花有效成分与药材粉末颜色的相关性[J]. 中国实验方剂学杂志, 2016, 022(024):64-69. 47. 吕婉灵, 刘左军, 张小瑞,等. 钝裂银莲花主要色素成分及适应机制的研究[J]. 天然产物研究与开发, 2019, 31(03):27-32. 48. 任丽, 贾田芊, 李兴欢,等. 黄花油点草药材的质量标准研究[J]. 中国药房, 2019, 030(008):1083-1090. 49. 曾海英,毛佳怡,李勇,朱怡,石明,秦礼康.黔苦5号全麦荞茶的营养与抗氧化、免疫调节功效评价研究[J].食品研究与开发,2019,40(15):50-57. 50. 师仁丽 翟龙飞 于文龙 等. 利用DAD-HPLC和LC-MS法检测金丝小枣中黄酮类化合物[J]. 食品科学 2016(16期):123-127. 51. 林羡, 徐玉娟, 肖更生,等. 干燥方式对辣木叶营养活性成分、抗氧化活性及色泽的影响[J]. 热带作物学报, 2018, 039(012):2465-2472. 52. 罗磊, 关宁宁, 向进乐,等. 牡丹花蕊醇提物对H_2O_2诱导HUVEC细胞损伤的保护作用[J]. 食品与机械, 2019, v.35;No.216(10):103-108. 53. 战妍妃, 李媛媛, 安欣欣,等. 石韦的抗病毒黄酮部位及有效化学成分[J]. 暨南大学学报:自然科学与医学版, 2018, 039(006):470-480. 54. 蔡爽, 阮成江, 杜维,等. 高效液相色谱-串联质谱法同时测定沙棘中的11种黄酮类物质[J]. 分析科学学报, 2019, 035(003):311-316. 55. 孔宇, 张倚菲, 韩鹏云,等. 沙棘籽粕多酚提取工艺优化,组分分析及抗氧化性能研究[J]. 中国油脂, 2020, 045(004):109-114. 56. 王婷婷, 苑伟, 李华,等. 复合小浆果果酒中的酚类物质及其抗氧化活性分析[J]. 食品与发酵工业, 2019, 45(03):183-188. 57. 张艺沛, 张婷, 史一恒,等. 藜麦茶加工工艺及酚类物质组成分析[J]. 食品科学, 2019, 040(012):267-274. 58. 黑青稞麸皮结合态酚类物质大孔树脂分离纯化工艺优化 59. 张炜,全昆,宋祖琪,高元喜,周刚,陈茂华.山柰酚抑制EMT阻断神经胶质瘤细胞侵袭和转移[J].时珍国医国药,2020,31(05):1097-1101. 60. 顾超,王恺纯,徐勤芬,刘微,胡道德.山柰酚调控PI3K/Akt/mTOR通路诱导人结直肠癌RKO细胞自噬[J].中南药学,2020,18(10):1668-1673. 61. 汪成,王怀友,汪蔓青,段然,李智浩,董婷霞,詹华强.不同产地沙棘果化学成分含量及抗氧化活性的研究[J].华西药学杂志,2020,35(05):513-517. 62. 张月,唐钦悦,代娟,魏香奕,颜佳利,江岩.桑叶黄酮提取物制备及其体外抗氧化作用研究[J].中国食品添加剂,2020,31(09):47-52. 63. 张宸,沈新春,包伊凡,张羽,韩欣然,汪芳.基于谱效相关的辣木籽抗氧化活性物质研究[J].食品科技,2021,46(02):189-197. 64. 周茂强,况杰,胡翰林,果磊.欧亚旋覆花总黄酮对衰老人皮肤成纤维细胞lncRNA TERRA的影响及其机制[J].解放军医学杂志,2020,45(11):1117-1124. 65. 蒋梦丹,夏鹏国,梁宗锁,许鑫瀚,陈喜良,韩蕊莲.基于显微结构、抗氧化活性和化学成分的三叶青须根入药的可行性研究[J].时珍国医国药,2020,31(10):2492-2495. 66. 赵萌萌,张文刚,党斌,杨希娟,张杰,甘生智.超微粉碎对青稞麸皮粉多酚组成及抗氧化活性的影响[J].农业工程学报,2020,36(15):291-298. 67. 肖贤,李丽,李琳玲,查三省,袁红慧,邓坤,程水源,程华.叶施有机硒对银杏叶总黄酮含量的影响[J].河南农业科学,2021,50(03):130-141. 68. 杨金鑫,常薇,刘伶文,王晓军.高效液相色谱法测定银杏叶提取物中的黄酮醇苷[J].纺织高校基础科学学报,2020,33(04):118-122. 69. 张恒,郑俏然,何靖柳,韦婷,刘翔,章斌.藏茶玫瑰乌梅无糖复合饮料研制及功能性成分分析与抗氧化研究[J].食品科技,2021,46(01):46-53+61. 70. 王文琪,李媛媛,王双,朱彦军,孙梦佳,蔡馥洁,孙晓慧,柳晴,周洪雷.败酱草总黄酮部位体外抗病毒活性成分研究[J].山东科学,2020,33(05):43-50. 71. Dong, Ruifang, et al. "Chemical fingerprint and quantitative analysis of flavonoids for quality control of Sea buckthorn leaves by HPLC and UHPLC-ESI-QTOF-MS." Journal of Functional Foods 37 (2017): 513-522.https://doi.org/10.1016/j.jff.2017.08.019 72. Song, Hongdong, et al. "Innovative assistant extraction of flavonoids from pine (Larix olgensis Henry) needles by high-density steam flash-explosion." Journal of agricultural and food chemistry 62.17 (2014): 3806-3812.https://doi.org/10.1021/jf405412r 73. Pei Pu, Xin Zheng, Linna Jiao, Lang Chen, Han Yang, Yonghong Zhang, Guizhao Liang, Six flavonoids inhibit the antigenicity of β-lactoglobulin by noncovalent interactions: A spectroscopic and molecular docking study, Food Chemistry, Volume 339, 2021, 128106 74. Yang, Jing, et al. "Determination of active compounds in raspberry leaf extracts and the effects of extract intake on mice." Food Science and Technology 40 (2019): 124-131.https://doi.org/10.1590/fst.35518 75. Qian, Suhong, et al. "Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity." Viruses 7.4 (2015): 1613-1626.https://doi.org/10.3390/v7041613 76. Dong, Qingying, et al. "Comparative study on phenolic compounds, triterpenoids, and antioxidant activity of Ganoderma lucidum affected by different drying methods." Journal of Food Measurement and Characterization 13.4 (2019): 3198-3205.https://doi.org/10. 77. Dong, Qingying, et al. "Comparative study on phenolic compounds, triterpenoids, and antioxidant activity of Ganoderma lucidum affected by different drying methods." Journal of Food Measurement and Characterization 13.4 (2019): 3198-3205.https://doi.org/10. 78. Shasha Jing, Huijun Zheng, Li Zhao, Lingbo Qu, Lanlan Yu,A novel electrochemical sensor based on WO3 nanorods-decorated poly(sodium 4-styrenesulfonate) functionalized graphene nanocomposite modified electrode for detecting of puerarin,Talanta,Volume 174 79. Nan, Xingmei, et al. "Bioactive fraction of Rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats." Journal of ethnopharmacology 216 (2018): 175-183.https://doi.org/10.1016/j.jep.2018.0 80. Liu, Huan, et al. "Antimicrobial activity and virulence attenuation of citral against the fish pathogen Vibrio alginolyticus." Aquaculture 515 (2020): 734578.https://doi.org/10.1016/j.aquaculture.2019.734578 81. Zhu, Hao, et al. "Anti-inflammatory effects of p-coumaric acid, a natural compound of Oldenlandia diffusa, on arthritis model rats." Evidence-Based Complementary and Alternative Medicine 2018 (2018).https://doi.org/10.1155/2018/5198594 82. Gao, Mingliang, et al. "Evaluation of VEGF mediated pro-angiogenic and hemostatic effects and chemical marker investigation for Typhae Pollen and its processed product." Journal of Ethnopharmacology 268 (2021): 113591.https://doi.org/10.1016/j.jep.2020.113 83. Yang, Wei, et al. "Liquid chromatography–mass spectrometry-based metabolomics analysis of flavonoids and anthraquinones in Fagopyrum tataricum L. Gaertn.(tartary buckwheat) seeds to trace morphological variations." Food chemistry 331 (2020): 127354.https:/ 84. Lyu, Yunbin, et al. "Identification and characterization of three flavonoid 3-O-glycosyltransferases from Epimedium koreanum Nakai." Biochemical Engineering Journal 163 (2020): 107759.https://doi.org/10.1016/j.bej.2020.107759 85. Yang, Jing, et al. "Comparisons of the active components in four unripe raspberry extracts and their activites." Food Science and Technology 39 (2019): 632-639.https://doi.org/10.1590/fst.27418 86. Zhang, Cao, et al. "Chemical structures of polyphenols that critically influence the toxicity of ZnO nanoparticles." Journal of agricultural and food chemistry 66.7 (2018): 1714-1722.https://doi.org/10.1021/acs.jafc.8b00368 87. [IF=7.514] Balarabe B. Ismail et al."LC-MS/QTOF identification of phytochemicals and the effects of solvents on phenolic constituents and antioxidant activity of baobab (Adansonia digitata) fruit pulp."Food Chem. 2019 Mar;277:279 88. [IF=6.057] Shasha Jing et al."A novel electrochemical sensor based on WO3 nanorods-decorated poly(sodium 4-styrenesulfonate) functionalized graphene nanocomposite modified electrode for detecting of puerarin."Talanta. 2017 Nov;174:477 89. [IF=5.396] Jiachan Zhang et al."Understanding the role of extracts from sea buckthorn seed residues in anti-melanogenesis properties on B16F10 melanoma cells."Food Funct. 2018 Oct;9(10):5402-5416 90. [IF=5.396] Meigui Huang et al."Encapsulation of flavonoids in liposomal delivery systems: the case of quercetin, kaempferol and luteolin."Food Funct. 2017 Sep;8(9):3198-3208 91. [IF=5.279] Hongdong Song et al."Innovative Assistant Extraction of Flavonoids from Pine (Larix olgensis Henry) Needles by High-Density Steam Flash-Explosion."J Agr Food Chem. 2014;62(17):3806–3812 92. [IF=5.279] Cao Zhang et al."Chemical Structures of Polyphenols That Critically Influence the Toxicity of ZnO Nanoparticles."J Agr Food Chem. 2018;66(7):1714–1722 93. [IF=5.279] Yingying Wei et al."Hot Air Treatment Induces Disease Resistance through Activating the Phenylpropanoid Metabolism in Cherry Tomato Fruit."J Agr Food Chem. 2017;65(36):8003–8010 94. [IF=5.165] Chunchao Zhao et al."An improved method to obtain essential oil, flavonols and proanthocyanidins from fresh Cinnamomum japonicum Sieb. leaves using solvent-free microwave-assisted distillation followed by homogenate extraction."Arab J Chem. 2020 Jan;13:20 95. [IF=4.939] Jinghui Wang et al."Systems Pharmacology Dissection of Multiscale Mechanisms of Action for Herbal Medicines in Treating Rheumatoid Arthritis."Mol Pharmaceut. 2017;14(9):3201–3217 96. [IF=4.545] Xing Su et al."Systems pharmacology uncover the mechanism of anti-non-small cell lung cancer for Hedyotis diffusa Willd."Biomed Pharmacother. 2019 Jan;109:969 97. [IF=4.411] Xuan Zeng et al."UFLC-Q-TOF-MS/MS-Based Screening and Identification of Flavonoids and Derived Metabolites in Human Urine after Oral Administration of Exocarpium Citri Grandis Extract."Molecules. 2018 Apr;23(4):895 98. [IF=4.411] Li Jia et al."Systematic Profiling of the Multicomponents and Authentication of Erzhi Pill by UHPLC/Q-Orbitrap-MS Oriented Rapid Polarity-Switching Data-Dependent Acquisition and Selective Monitoring of the Chemical Markers Deduced from Fingerprint Analys 99. [IF=4.411] Xiaosheng Tang et al."Molecular Structure–Affinity Relationship of Flavonoids in Lotus Leaf (Nelumbo nucifera Gaertn.) on Binding to Human Serum Albumin and Bovine Serum Albumin by Spectroscopic Method."Molecules. 2017 Jul;22(7):1036 100. [IF=4.379] Wang Jinghui et al."A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula."Sci Rep-Uk. 2017 May;7(1):1-22 101. [IF=3.811] Suhong Qian et al."Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity."Viruses-Basel. 2015 Apr;7(4):1613-1626 102. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56 103. [IF=3.645] Lijuan Wang et al."Systematic characterization and simultaneous quantification of the multiple components of Rhododendron dauricum based on high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry."J Sep Sci. 2015 Sep 104. [IF=3.638] Yunfeng Pu et al."Effect of harvest, drying and storage on the bitterness, moisture, sugars, free amino acids and phenolic compounds of jujube fruit (Zizyphus jujuba cv. Junzao)."J Sci Food Agr. 2018 Jan;98(2):628-634 105. [IF=3.046] Liwei Dong et al."Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1."Oncotargets Ther. 2015; 8: 3649–3664 106. [IF=2.411] Wenqi Gao et al."Antidepressive effects of kaempferol mediated by reduction of oxidative stress, proinflammatory cytokines and up-regulation of AKT/β-catenin cascade."Metab Brain Dis. 2019 Apr;34(2):485-494 107. [IF=2.408] Ji-Xiao Zhu et al."Quercetin, Kaempferol and Isorhamnetin in Elaeagnus pungens Thunb. Leaf: Pharmacological Activities and Quantitative Determination Studies."Chem Biodivers. 2018 Aug;15(8):e1800129 108. [IF=1.984] Zhu Hao et al."Anti-Inflammatory Effects of the Bioactive Compound Ferulic Acid Contained in Oldenlandia diffusa on Collagen-Induced Arthritis in Rats."Evid-Based Compl Alt. 2014;2014:573801 109. [IF=1.984] Zhu Hao et al."Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats."Evid-Based Compl Alt. 2018;2018:5198594 110. [IF=9.811] Manjie Gao et al."High-Crystallinity Covalent Organic Framework Synthesized in Deep Eutectic Solvent: Potentially Effective Adsorbents Alternative to Macroporous Resin for Flavonoids."Chem Mater. 2021;33(20):8036–8051 111. [IF=9.147] Jianzhong Zhu et al."Effect of Rosa Roxburghii juice on starch digestibility: A focus on the binding of polyphenols to amylose and porcine pancreatic α-amylase by molecular modeling."Food Hydrocolloid. 2022 Feb;123:106966 112. [IF=7.963] Balarabe B. Ismail et al."Characterizing the phenolic constituents of baobab (Adansonia digitata) fruit shell by LC-MS/QTOF and their in vitro biological activities."Sci Total Environ. 2019 Dec;694:133387 113. [IF=7.514] Chu-Yang Wang et al."Isolation of wheat mutants with higher grain phenolics to enhance anti-oxidant potential."Food Chem. 2020 Jan;303:125363 114. [IF=7.514] Yuan Cheng et al."Dual effects of quercetin on protein digestion and absorption in the digestive tract."Food Chem. 2021 Oct;358:129891 115. [IF=7.514] Balarabe B. Ismail et al."High-intensity ultrasound processing of baobab fruit pulp: Effect on quality, bioactive compounds, and inhibitory potential on the activity of α-amylase and α-glucosidase."Food Chem. 2021 Nov;361:130144 116. [IF=6.529] Qi Huang et al."Systematic investigation of the pharmacological mechanism for renal protection by the leaves of Eucommia ulmoides Oliver using UPLC-Q-TOF/MS combined with network pharmacology analysis."Biomed Pharmacother. 2021 Aug;140:111735 117. [IF=6.513] Balarabe B. Ismail et al."Ultrasound-assisted adsorption/desorption for the enrichment and purification of flavonoids from baobab (Adansonia digitata) fruit pulp."Ultrason Sonochem. 2020 Jul;65:104980 118. [IF=6.306] Wei Yang et al."Liquid chromatography–mass spectrometry-based metabolomics analysis of flavonoids and anthraquinones in Fagopyrum tataricum L. Gaertn. (tartary buckwheat) seeds to trace morphological variations."Food Chem. 2020 Nov;331:127354 119. [IF=6.081] Tongji Liu et al."Improvement Effect of Lotus Leaf Flavonoids on Carbon Tetrachloride-Induced Liver Injury in Mice."Biomedicines. 2020 Feb;8(2):41 120. [IF=6.023] Maiquan Li et al."Discovery of Keap1−Nrf2 small−molecule inhibitors from phytochemicals based on molecular docking."Food Chem Toxicol. 2019 Nov;133:110758 121. [IF=6.023] Mengxue Diao et al."Enhanced cytotoxicity and antioxidant capacity of kaempferol complexed with α-lactalbumin."Food Chem Toxicol. 2021 Jul;153:112265 122. [IF=5.81] Mu Jianfei et al."Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects."Fro 123. [IF=5.645] Ying Guo et al."Metabolome and transcriptome analyses reveal flavonoids biosynthesis differences in Ginkgo biloba associated with environmental conditions."Ind Crop Prod. 2020 Dec;158:112963 124. [IF=5.645] Ying Guo et al."Spatial prediction and delineation of Ginkgo biloba production areas under current and future climatic conditions."Ind Crop Prod. 2021 Aug;166:113444 125. [IF=5.279] Qinggang Yin et al."Identification of Specific Glycosyltransferases Involved in Flavonol Glucoside Biosynthesis in Ginseng Using Integrative Metabolite Profiles, DIA Proteomics, and Phylogenetic Analysis."J Agr Food Chem. 2021;69(5):1714–1726 126. [IF=5.11] Xiaonan Liu et al."De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae."Acs Synth Biol. 2020;9(11):3042–3051 127. [IF=4.952] Shuxin Tang et al."Effect of Lactobacillus plantarum-fermented mulberry pomace on antioxidant properties and fecal microbial community."Lwt Food Sci Technol. 2021 Jul;147:111651 128. [IF=4.952] Yuxin Hao et al."Stability and mechanism of phenolic compounds from raspberry extract under in vitro gastrointestinal digestion."Lwt Food Sci Technol. 2021 Mar;139:110552 129. [IF=4.952] Zhiqiang Hou et al."Processing of chestnut rose juice using three-stage ultra-filtration combined with high pressure processing."Lwt Food Sci Technol. 2021 May;143:111127 130. [IF=4.879] Yang Liu et al."UV-B Radiation Largely Promoted the Transformation of Primary Metabolites to Phenols in Astragalus mongholicus Seedlings."Biomolecules. 2020 Apr;10(4):504 131. [IF=4.769] Yuan Hong et al."Determination of bioactive components in the fruits of Cercis chinensis Bunge by HPLC-MS/MS and quality evaluation by principal components and hierarchical cluster analyses."J Pharm Anal. 2021 Aug;11:465 132. [IF=4.599] Guo Ying et al."Temporospatial Flavonoids Metabolism Variation in Ginkgo biloba Leaves."Front Genet. 2020 Nov;0:1503 133. [IF=4.411] Ning Jin et al."Comprehensive Evaluation of Amino Acids and Polyphenols in 69 Varieties of Green Cabbage (Brassica oleracea L. var. capitata L.) Based on Multivariate Statistical Analysis."Molecules. 2021 Jan;26(17):5355 134. [IF=4.411] Zong-Jin Pu et al."The Comprehensive Evaluation of Safflowers in Different Producing Areas by Combined Analysis of Color, Chemical Compounds, and Biological Activity."Molecules. 2019 Jan;24(18):3381 135. [IF=4.36] Li Lin et al."Study on the alleviation of Fengshi Gutong capsule on rheumatoid arthritis through integrating network pharmacology and experimental exploration."J Ethnopharmacol. 2021 Nov;280:114471 136. [IF=4.36] Peng-yu Chen et al."Revealing the mechanism of “Huai Hua San” in the treatment of ulcerative colitis based on network pharmacology and experimental study."J Ethnopharmacol. 2021 Dec;281:114321 137. [IF=4.36] Mingliang Gao et al."Evaluation of VEGF mediated pro-angiogenic and hemostatic effects and chemical marker investigation for Typhae Pollen and its processed product."J Ethnopharmacol. 2021 Mar;268:113591 138. [IF=4.27] Zhikang Zhao et al."Functional analysis of PpRHM1 and PpRHM2 involved in UDP-l-rhamnose biosynthesis in Prunus persica."Plant Physiol Bioch. 2020 Oct;155:658 139. [IF=4.24] Nana Li et al."Characterization of phenolic compounds and anti-acetylcholinase activity of coconut shells."Food Biosci. 2021 Aug;42:101204 140. [IF=4.235] Dong Qingying et al."High Oxygen Treatments Enhance the Contents of Phenolic Compound and Ganoderic Acid, and the Antioxidant and DNA Damage Protective Activities of Ganoderma lingzhi Fruiting Body."Front Microbiol. 2019 Oct;0:2363 141. [IF=4.192] Qiangqiang Li et al."Bee Pollen Extracts Modulate Serum Metabolism in Lipopolysaccharide-Induced Acute Lung Injury Mice with Anti-Inflammatory Effects."J Agr Food Chem. 2019;67(28):7855–7868 142. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 143. [IF=4.032] Qiu-yue Xiao et al."A network pharmacology-based study on key pharmacological pathways and targets of Qi Fu Yin acting on Alzheimer's disease."Exp Gerontol. 2021 Jul;149:111336 144. [IF=3.978] Yunbin Lyu et al."Identification and characterization of three flavonoid 3-O-glycosyltransferases from Epimedium koreanum Nakai."Biochem Eng J. 2020 Nov;163:107759 145. [IF=3.935] Jingyun Zheng et al."A systematic investigation on free phenolic acids and flavonoids profiles of commonly consumed edible flowers in China."J Pharmaceut Biomed. 2019 Aug;172:268 146. [IF=3.935] Jun-cheng Liao et al."Comprehensive evaluation of NAODESHENG by combining UPLC quantitative fingerprint and antioxidant activity."J Pharmaceut Biomed. 2021 Jan;193:113636 147. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002 148. [IF=3.645] Qingyu Zhang et al."Quality control of Semen Hoveniae by high-performance liquid chromatography coupled to Fourier transform-ion cyclotron resonance mass spectrometry."J Sep Sci. 2021 Sep;44(18):3366-3375 149. [IF=3.645] Jie Lu et al."Identification and determination of chemical constituents from Yinchen Qingjin granules by ultra high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry."J Sep Sci. 2021 Apr;44(7):1324-1344 150. [IF=3.616] Meng Zhang et al."Comparative evaluation on phenolic profiles, antioxidant properties and α-glucosidase inhibitory effects of different milling fractions of foxtail millet."J Cereal Sci. 2021 May;99:103217 151. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788 152. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 153. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 154. [IF=2.863] Qiaoran Zheng et al."Optimizing synchronous extraction and antioxidant activity evaluation of polyphenols and polysaccharides from Ya'an Tibetan tea (Camellia sinensis)."Food Sci Nutr. 2020 Jan;8(1):489-499 155. [IF=2.72] Wenfeng Li et al."Citric acid-enhanced dissolution of polyphenols during soaking of different teas."J Food Biochem. 2019 Dec;43(12):e13046 156. [IF=2.633] Yanni Cao et al."Seasonal Variation in Phenolic Compounds and Antioxidant Activity in Leaves of Cyclocarya paliurus (Batal.) Iljinskaja."Forests. 2019 Aug;10(8):624 157. [IF=2.629] Su Xing et al."Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula."Evid-Based Compl Alt. 2019;2019:9854047 158. [IF=2.461] Yang Qian et al."The disruption of the MAPKK gene triggering the synthesis of flavonoids in endophytic fungus Phomopsis liquidambaris."Biotechnol Lett. 2021 Jan;43(1):119-132 159. [IF=2.431] Dong Qingying et al."Comparative study on phenolic compounds, triterpenoids, and antioxidant activity of Ganoderma lucidum affected by different drying methods."J Food Meas Charact. 2019 Dec;13(4):3198-3205 160. [IF=2.19] Sheng-xiang Yang et al."Extraction of flavonoids from Cyclocarya paliurus (Juglandaceae) leaves using ethanol/salt aqueous two-phase system coupled with ultrasonic."J Food Process Pres. 2020 Jun;44(6):e14469 161. [IF=1.77] Muhammad Khalid et al."Suppression of clubroot (Plasmodiophora brassicae) development in Brassica campestris sp. chinensis L. via exogenous inoculation of Piriformospora indica."J Radiat Res Appl Sc. 2020;13(1):180-190 162. [IF=1.554] Yafen Fu et al."Electrochemical evaluation of the antioxidant capacity of natural compounds on glassy carbon electrode modified with guanine-, polythionine-, and nitrogen-doped graphene."Open Chem. 2020 Jan;18(1):1054-1063 163. [IF=1.552] Fang Mingyue et al."Qualitative and Quantitative Analysis of 24 Components in Jinlianhua Decoction by UPLC–MS/MS."Chromatographia. 2019 Dec;82(12):1801-1825 164. [IF=6.793] Luo Xiaoning et al.Integrating full-length transcriptomics and metabolomics reveals the regulatory mechanisms underlying yellow pigmentation in tree peony (Paeonia suffruticosa Andr.) flowers.Hortic Res-England. 2021 Nov;8(1):1-15 165. [IF=6.057] Qi Tong et al.Biosynthesis-based spatial metabolome of Salvia miltiorrhiza Bunge by combining metabolomics approaches with mass spectrometry-imaging.Talanta. 2021 Nov;:123045 166. [IF=4.411] Yue Li et al.Impact of Drying Methods on Phenolic Components and Antioxidant Activity of Sea Buckthorn (Hippophae rhamnoides L.) Berries from Different Varieties in China.Molecules. 2021 Jan;26(23):7189 167. [IF=5.34] Yule Wang et al."Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke."Phytomedicine. 2022 May;99:154034 168. [IF=6.244] Yalei Wang et al."Exploration of the Potential Mechanism of Qi Yin San Liang San Decoction in the Treatment of EGFRI-Related Adverse Skin Reactions Using Network Pharmacology and In Vitro Experiments.."Front Oncol. 2022 Mar;12:790713-790713 169. [IF=6.475] Jinxin Li et al."Trapping of reactive carbonyl species by fiber-bound polyphenols from whole grains under simulated physiological conditions."Food Res Int. 2022 Jun;156:111142 170. [IF=2.998] Zan Shengyue et al."Composition analysis of rootstock cherry (Prunus mahaleb L.), a potential source of human nutrition and dietary supplements."Eur Food Res Technol. 2022 Feb;:1-15 171. [IF=4.379] Yan Min et al."Physicochemical and antioxidant activity of fruit harvested from eight jujube (Ziziphus jujuba Mill.) cultivars at different development stages."Sci Rep-Uk. 2022 Feb;12(1):1-13 172. [IF=4.987] Shang Xian-chao et al."Temperature-responsive deep eutectic solvents as eco-friendly and recyclable media for microwave extraction of flavonoid compounds from waste onion (Allium cepa L.) skins."Biomass Convers Bior. 2022 Feb;:1-10 173. [IF=5.81] Zhu DW et al."Exploring the Anti-Pulmonary Fibrosis Mechanism of Jingyin Granule by Network Pharmacology Strategy.."Front Pharmacol. 2022 Feb;13:825667-825667 174. [IF=6.529] Fanying Meng et al."Virtual screening and in vitro experimental verification of LuxS inhibitors from natural products for Lactobacillus reuteri."Biomed Pharmacother. 2022 Mar;147:112521 175. [IF=1.312] Xiaoran Zhao et al."Discrimination of Cuscuta chinensis Lam. and Cuscuta japonica Choisy based on a combination of chemometrics and fingerprint classification."Journal Of Liquid Chromatography & Related Technologies. 2022 Jan 09 176. [IF=3.645] Yu Zhang et al."Qualitative and quantitative analysis of Alpiniae Oxyphyllae fructus by HPLC coupled to Fourier transform-ion cyclotron resonance mass spectrometry."Journal Of Separation Science. 2022 Jan 11 177. [IF=3.935] Junmao Li et al."Comprehensive chemical profiling of the flowers of Citrus aurantium L. var. amara Engl. and uncovering the active ingredients of lipid lowering."J Pharmaceut Biomed. 2022 Mar;211:114621 178. [IF=4.556] Yiyu Ren et al."Metabolomics, sensory evaluation, and enzymatic hydrolysis reveal the effect of storage on the critical astringency-active components of crude Pu-erh tea."J Food Compos Anal. 2022 Apr;107:104387 179. [IF=4.411] Junfeng Hao et al."Comparative Analysis of Major Flavonoids among Parts of Lactuca indica during Different Growth Periods."Molecules. 2021 Jan;26(24):7445 180. [IF=4.411] Shangwen He et al."Suppressing Alpha-Hemolysin as Potential Target to Screen of Flavonoids to Combat Bacterial Coinfection."Molecules. 2021 Jan;26(24):7577 181. [IF=5.753] Jianghong Gao et al."Molecular Cloning and Functional Characterization of a Sterol 3-O-Glucosyltransferase Involved in Biosynthesis of Steroidal Saponins in Trigonella foenum-graecum.."Front Plant Sci. 2021 Dec;12:809579-809579 182. [IF=7.46] Shuo Wang et al."A novel visual sensing method based on Al@AuNCs for rapid identification of Chrysanthemum morifolium from different origins."Sensor Actuat B-Chem. 2022 Apr;356:131307 183. [IF=3.373] Yiyuan Luo et al."Quality evaluation of Tetrastigma hemsleyanum different parts based on quantitative analysis of 42 bioactive constituents combined with multivariate statistical analysis."PHYTOCHEMICAL ANALYSIS. 2022 Apr 05 184. [IF=3.24] YanShou Shi et al."Seasonal variation influences flavonoid biosynthesis path and content, and antioxidant activity of metabolites in Tetrastigma hemsleyanum Diels & Gilg."PLoS One. 2022 Apr;17(4):e0265954 185. [IF=4.412] Haifan Liu et al."Pharmacokinetics, Prostate Distribution and Metabolic Characteristics of Four Representative Flavones after Oral Administration of the Aerial Part of Glycyrrhiza uralensis in Rats."MOLECULES. 2022 Jan;27(10):3245 186. [IF=4.412] Hui-Min Jin et al."Polyphenol and Anthocyanin Composition and Activity of Highland Barley with Different Colors."MOLECULES. 2022 Jan;27(11):3411 187. [IF=5.34] Mingliang Gao et al."Discovery of processing-associated Q-marker of carbonized traditional Chinese medicine: an integrated strategy of metabolomics, systems pharmacology and in vivo high-throughput screening model."PHYTOMEDICINE. 2022 May;:154152 188. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 189. [IF=4.781] Limei Lin et al."Integrative analysis of transcriptome and metabolome reveals the effect of DNA methylation of chalcone isomerase gene in promoter region on Lithocarpus polystachyus Rehd flavonoids."Synthetic and Systems Biotechnology. 2022 Sep;7:928 190. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 191. [IF=6.543] Liu Yilong et al."Two Myricetin-Derived Flavonols from Morella rubra Leaves as Potent α-Glucosidase Inhibitors and Structure-Activity Relationship Study by Computational Chemistry."Oxidative Medicine and Cellular Longevity. 2022;2022:9012943 192. [IF=2.63] Li Hangchao et al."Bushen Jianpi Quyu Formula Alleviates Myelosuppression of an Immune-Mediated Aplastic Anemia Mouse Model via Inhibiting Expression of the PI3K/AKT/NF-κB Signaling Pathway."Evidence-based Complementary and Alternative Medicine. 2022;2022: 193. [IF=4.24] Jun Li et al."In vitro xanthine oxidase inhibitory properties of Flos Sophorae Immaturus and potential mechanisms."Food Biosci. 2022 Jun;47:101711 194. [IF=2.863] Jue Cui et al."Burdock (Arctium lappa L.) leaf flavonoids rich in morin and quercetin 3-O-rhamnoside ameliorate lipopolysaccharide-induced inflammation and oxidative stress in RAW264.7 cells."Food Science & Nutrition 195. [IF=3.713] Ren Li et al."Effects of germination time on phenolics, antioxidant capacity, in vitro phenolic bioaccessibility and starch digestibility in sorghum."INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!