desferrioxaminebmesylate
甲磺酸去铁敏(deferoxamine mesylate)
CAS: 138-14-7
化学式: C26H52N6O11S
| 中文名 | 甲磺酸去铁敏 |
| 英文名 | deferoxamine mesylate |
| 别名 | 去铁铵 甲磺酸去铁敏 甲磺酸去铁胺 甲磺酸除铁灵 去铁胺甲磺酸酯 去铁胺甲磺酸盐 DEFEROX胺甲磺酸盐 |
| 英文别名 | desferal desferalmesylate deferoxaminemesilate deferoxamine mesilate deferoxamine mesylate deferoxaminebmesylate desferalmethanesulfonate desferrioxaminebmesylate deferoxaminemethanesulfonate Deferoxamine Mesylate (300 mg) |
| CAS | 138-14-7 |
| EINECS | 205-314-3 |
| 化学式 | C26H52N6O11S |
| 分子量 | 656.79 |
| InChI | InChI=1/C25H48N6O8.2CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;2*1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);2*1H3,(H,2,3,4) |
| 熔点 | 148-149° |
| 沸点 | 1061.9°C at 760 mmHg |
| 闪点 | 596°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | H2O: 50 mg/mL |
| 存储条件 | 2-8°C |
| 外观 | 粉末 |
| 颜色 | white to off-white |
| MDL号 | MFCD00058605 |
| 体外研究 | Deferoxamine treatment significantly increases HIF-1α binding under all culture conditions, including hypoxic and high-glucose. The mechanism of deferoxamine is through improving HIF-1α biological function through scavenging oxygen free radicals. Deferoxamine (5 μM) has significant effect on the tumor-associated stromal cells cellular multiplication, and cells die at day 7 after exposure to 50 μM and 100 μM deferoxamine. Deferoxamine (5 μM-100 μM) inhibits the proliferation of BMMSCs, and induces apoptosis of MSCs in a dose-dependent manner. Deferoxamine influences the expression of adhesion proteins on MSCs. Deferoxamine (30, 60, 120 μM) shows lower expression of HIF-1α in a concentration dependent way in AdMSCs. |
| 体内研究 | Deferoxamine (100 mg/kg, i.p.) lowers the mortality rate of subarachnoid hemorrhage (SAH) rat. Deferoxamine (100 mg/kg, i.p.) attenuates Evan’s blue extravasation in cortex, ameliorates the tight junction detachment and preserves the integrity of the base membrane examined in electron microscope at day 3 after SAH. Deferoxamine attenuates degradation of BBB proteins after SAH and significantly reduces ferritin expression at day 3 in the cortex, and improves neurologic behavior and cognitive deficits after experimental. Ten µL of 1 mM deferoxamine-treated wounds display significantly accelerated healing from day 7 onward and heal significantly faster than control-treated wounds in diabetic mice. Deferoxamine-treated wounds and dimethyloxalylglycine-treated wounds heal significantly faster than control-treated wounds in aged mice. In deferoxamine (10 mg/mL)-treated TG mice, there is a decrease in both soluble and insoluble Aβ40 and Aβ42. Both pGSK3β and β-catenin are significantly increased by approximately 50% in the deferoxamine-treated mice. |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 2 |
| RTECS | UG5310000 |
| 海关编号 | 29280000 |
| 参考资料 展开查看 | 1. 马东来, 刘爱朋, 张园园,等. 紫外-可见光分光光度法测定去铁胺的含量[J]. 分析试验室, 2017, 036(003):289-291. 2. [IF=14.593] Xin Zhang et al."Modulating degradation of sodium alginate/bioglass hydrogel for improving tissue infiltration and promoting wound healing."Bioact Mater. 2021 Nov;6:3692 3. [IF=12.479] Junrui Wang et al."Tumor-self-targeted “thermoferroptosis-sensitization” magnetic nanodroplets for multimodal imaging-guided tumor-specific therapy."Biomaterials. 2021 Oct;277:121100 4. [IF=8.183] Zhicheng Zhang et al."Versatile iron-vitamin K 3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy."Nano Res. 2021 Jul;14(7):2398-2409 5. [IF=6.313] Yijia Yang et al."Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin."Antioxidants-Basel. 2022 Apr;11(4):710 |
desferrioxaminebmesylate - 简介
甲磺酸去铁敏是一种有机化合物。
溶解性：它可以在水中溶解，也可以在醇中、乙醚中和酸性溶液中溶解。
甲磺酸去铁敏主要用途是作为药品的原料。它是一种去铁的草酸衍生物，可与铁离子形成配合物，从而发挥去除铁的作用。
甲磺酸去铁敏的制法主要是通过将草酸与甲基磺酸缩合反应得到。具体制备过程中涉及到反应温度、反应时间、催化剂等条件的控制。
安全信息：甲磺酸去铁敏属于一种化学品，使用时应注意以下事项：
毒性：甲磺酸去铁敏在一定浓度下对人体有毒，接触或吸入过多可能引起刺激和损害，应避免直接接触皮肤和眼睛，使用时应佩戴防护手套和护目镜。
运输和储存：甲磺酸去铁敏应存放在干燥、通风的地方，并避免与氧化剂和酸性物质接触，防止发生火灾或爆炸。
废弃物处理：废弃的甲磺酸去铁敏应按照有关法规进行处理，避免对环境造成污染。
最重要的是，使用甲磺酸去铁敏时应严格按照相关操作规程进行，并在了解其性质、用途和安全信息的基础上进行安全操作。
溶解性：它可以在水中溶解，也可以在醇中、乙醚中和酸性溶液中溶解。
甲磺酸去铁敏主要用途是作为药品的原料。它是一种去铁的草酸衍生物，可与铁离子形成配合物，从而发挥去除铁的作用。
甲磺酸去铁敏的制法主要是通过将草酸与甲基磺酸缩合反应得到。具体制备过程中涉及到反应温度、反应时间、催化剂等条件的控制。
安全信息：甲磺酸去铁敏属于一种化学品，使用时应注意以下事项：
毒性：甲磺酸去铁敏在一定浓度下对人体有毒，接触或吸入过多可能引起刺激和损害，应避免直接接触皮肤和眼睛，使用时应佩戴防护手套和护目镜。
运输和储存：甲磺酸去铁敏应存放在干燥、通风的地方，并避免与氧化剂和酸性物质接触，防止发生火灾或爆炸。
废弃物处理：废弃的甲磺酸去铁敏应按照有关法规进行处理，避免对环境造成污染。
最重要的是，使用甲磺酸去铁敏时应严格按照相关操作规程进行，并在了解其性质、用途和安全信息的基础上进行安全操作。
最后更新：2024-04-09 20:49:11
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