中文名 | iRucaparib-AP6 |
英文名 | iRucaparib-AP6 |
英文别名 | iRucaparib-AP6 IRUCAPARIB-AP6 |
CAS | 2410557-00-3 |
化学式 | C46H55FN6O11 |
分子量 | 886.96 |
存储条件 | -20°C,惰性气体保存 |
体外研究 | iRucaparib-AP6 (0-10 μM; 24 hours) decreases PARP-1 level in a dose dependent manner, exhibits a half-maximal degrading concentration (DC 50 ) of 82 nM (D max = 92%). iRucaparib-AP6 (0-20 μM; 24 hours) induces degradation of PARP1 at low concentrations. Cell Viability Assay Cell Line: Primary rat neonatal cardiomyocyte cells Concentration: 0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM Incubation Time: 24 hours Result: Decreased PARP-1 level in primary rat neonatal cardiomyocyte cells. Western Blot Analysis Cell Line: Primary rat neonatal cardiomyocyte cells Concentration: 0.05 μM; 0.1 μM; 0.2 μM; 0.5 μM; 1 μM; 2 μM; 5 μM;10 μM; 20 μM Incubation Time: 24 hours Result: Induced robust PARP1 degradation at concentrations as low as 50 nM. |
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