中文名 | ml390 |
英文名 | ml390 |
别名 | 化合物ML390 |
英文别名 | ml390 Benzamide, N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)- |
CAS | 2029049-79-2 |
化学式 | C21H21F3N2O3 |
分子量 | 406.4 |
密度 | 1.31±0.1 g/cm3(Predicted) |
沸点 | 599.7±50.0 °C(Predicted) |
酸度系数 | 13.65±0.46(Predicted) |
存储条件 | Room Temprature |
体外研究 | ML390 is active with an ED 50 of ~2 μM in murine and human AML cell lines. In vitro, treatment of Lys-GFP-ER-HoxA9 cells with ML390 for 48 hr inhibits DHODH activity, leading to the dramatic (>500-fold) accumulation of the upstream metabolite DHO and the depletion of uridine and other downstream metabolites. |
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