二甲双胍
甲福明(metformin)
CAS: 657-24-9
化学式: C4H11N5
| 中文名 | 甲福明 |
| 英文名 | metformin |
| 别名 | 甲福明 双甲胍 降糖片 二甲双胍 盐酸二甲双胍D6 1,1-二甲基双胍 |
| 英文别名 | dmgg la6023 melbin flumamine gliguanid metformin haurymelin dimethylbiguanide 1,1-dimethyl-biguanid 1,1-dimethylbiguanide |
| CAS | 657-24-9 |
| EINECS | 211-517-8 |
| 化学式 | C4H11N5 |
| 分子量 | 129.16 |
| InChI | InChI=1/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8) |
| 密度 | 1.0743 (rough estimate) |
| 熔点 | 199-200 °C |
| 沸点 | 229.23°C (rough estimate) |
| 溶解度 | 乙腈 (微溶)，酸水溶液 (微溶)，二氯甲烷 (微溶)，DM |
| 折射率 | 1.5760 (estimate) |
| 酸度系数 | pKa 2.8(H2O,t =32) (Uncertain) |
| 存储条件 | Keep in dark place,Inert atmosphere,Room temperature |
| 外观 | 固体 |
| 颜色 | White to Light Brown |
| 上游原料 | 二氨腈 盐酸 |
| 下游产品 | (4-氨基-S-三嗪-2-基)-二甲基-胺 |
| 参考资料 展开查看 | 1. Cai, Wu-Dan, et al. "Hypoglycemic benefit and potential mechanism of a polysaccharide from Hericium erinaceus in streptozotoxin-induced diabetic rats." Process Biochemistry 88 (2020): 180-188.https://doi.org/10.1016/j.procbio.2019.09.035 2. Li, Yan, et al. "Dezhou donkey (Equus asinus) milk a potential treatment strategy for type 2 diabetes." Journal of ethnopharmacology 246 (2020): 112221.https://doi.org/10.1016/j.jep.2019.112221 3. [IF=3.267] Ping Zhao et al."Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2+."Molecules. 2018 Nov;23(11):2934 4. [IF=3.225] Wenhao Xu et al."Mechanochemical preparation of kaempferol intermolecular complexes for enhancing the solubility and bioavailability."Drug Dev Ind Pharm. 2018;44(12):1924-1932 5. [IF=2.371] Liu Changhe et al."Metformin Regulates the Expression of SK2 and SK3 in the Atria of Rats With Type 2 Diabetes Mellitus Through the NOX4/p38MAPK Signaling Pathway."J Cardiovasc Pharm. 2018 Nov;72(5):205-213 6. [IF=5.396] Yao-Yao Wang et al."Antidiabetic activity of a polysaccharide-protein complex from Asian Clam (Corbicula fluminea) in streptozotoxin-induced diabetic rats and its underlying mechanism."Food Funct. 2019 Sep;10(9):5574-5586 7. [IF=5.279] Mengdi Chen et al."Novel Umami Peptide IPIPATKT with Dual Dipeptidyl Peptidase-IV and Angiotensin I-Converting Enzyme Inhibitory Activities."J Agr Food Chem. 2021;69(19):5463–5470 8. [IF=4.818] Yong Zhang et al."Mangiferin Ameliorates HFD-Induced NAFLD through Regulation of the AMPK and NLRP3 Inflammasome Signal Pathways."J Immunol Res. 2021;2021:4084566 9. [IF=4.225] Zhang Yi et al."Edgeworthia gardneri (Wall.) Meisn. Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3β/FoxO1 Signaling Pathway in Human HepG2 Hepatocytes."Front Pharmacol. 2020 Jan;0:1666 10. [IF=4.171] Lin Han et al."Activation of AMPK/Sirt3 pathway by phloretin reduces mitochondrial ROS in vascular endothelium by increasing the activity of MnSOD via deacetylation."Food Funct. 2020 Apr;11(4):3073-3083 11. [IF=3.757] Wu-Dan Cai et al."Hypoglycemic benefit and potential mechanism of a polysaccharide from Hericium erinaceus in streptozotoxin-induced diabetic rats."Process Biochem. 2020 Jan;88:180 12. [IF=3.718] K e et al."Glucose-lowering activity of dark tea protein extract by modulating spleen–brain axis of diabetic mice."Brit J Nutr. 2020 Dec;126(7):961-969 13. [IF=3.414] Yan Li et al."Dezhou donkey (Equus asinus) milk a potential treatment strategy for type 2 diabetes."J Ethnopharmacol. 2020 Jan;246:112221 14. [IF=5.34] Yi Kuang et al.A network pharmacology-based strategy to explore the pharmacological mechanisms of Antrodia camphorata and antcin K for treating type II diabetes mellitus.Phytomedicine. 2021 Nov;:153851 15. [IF=7.658] Guang-Jie Tai et al."NLRP3 inflammasome links vascular senescence to diabetic vascular lesions."Pharmacol Res. 2022 Apr;178:106143 |
二甲双胍 - 简介
甲福明是一种化学物质。下面是关于甲福明的性质、用途、制法和安全信息的介绍：
性质：
- 外观：白色晶体或结晶粉末；
- 可溶性：甲福明可在醚、酯、酮、芳香烃等有机溶剂中溶解，略溶于水。
用途：
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性质：
- 外观：白色晶体或结晶粉末；
- 可溶性：甲福明可在醚、酯、酮、芳香烃等有机溶剂中溶解，略溶于水。
用途：
-
最后更新：2024-04-09 02:00:10
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