中文名 | 依氟鸟氨酸 |
英文名 | Eflornithine |
别名 | 依氟乌氨酸 依氟鸟氨酸 依氟鸟氨酸碱 二氟甲基鸟氨酸 依氟鸟氨酸碱盐酸盐 消旋型二氟甲基腈盐酸盐 依氟鸟氨酸碱(消旋体) 依氟鸟氨酸碱 (混旋体) 消旋型二氟甲基腈盐酸盐 DL-Α-二氟甲基鸟氨酸盐酸盐 DL-ALPHA-二氟甲基鸟氨酸盐酸盐 |
英文别名 | Dfmo DFMO Ccris 3295 Brn 2250529 Eflornithine Eflornithine base DIFLUOROMETHYLORNITHINE 2-(difluoromethyl)ornithine 2-(difluoromethyl)-ornithin DIFLUOROMETHYLORNITHINE(RG) alpha-difluromethylornithine H-DL-(A-DIFLUOROMETHYL)ORN-OH α-Difluoromethyl-DL-ornithine D,L-2-DIFLUOROMETHYLORNITHINE alpha-difluoromethylornithine H-.alpha.-Difluoro-Me-DL-Orn-OH DL-α-Difluoromethylornithine hydrochloride 96020-91-6 (Mono-hydrochloride, monohydrate) DL-2-(Difluoromethyl)-ornithinehydrochloride alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid DL-α-Difluoromethylornithine hydrochloride hydrate,2-(Difluoromethyl)ornithine hydrochloride hydrate, DFMO hydrochloride hydrate, Eflornithine hydrochloride hydrate |
CAS | 67037-37-0 70052-12-9 |
化学式 | C6H12F2N2O2 |
分子量 | 182.17 |
InChI | InChI=1/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12) |
密度 | 1.1800 (estimate) |
熔点 | 138 °C |
沸点 | 347.0±42.0 °C(Predicted) |
闪点 | 163.7°C |
蒸汽压 | 9.72E-06mmHg at 25°C |
溶解度 | H2O: >10mg/ml,可溶 |
折射率 | 1.462 |
酸度系数 | 1.22±0.44(Predicted) |
存储条件 | Store at 0°C |
外观 | 固体 |
颜色 | white |
体内研究 | Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension. |
WGK Germany | 3 |
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