儿茶素没食子酸酯

中文名	儿茶素没食子酸酯
英文名	Catechin gallate
别名	儿茶素没食子酸儿茶素没食子酸酯儿茶素没食子酯酸儿茶素没食子酸酯CG (-)-没食子酸儿茶素酯 (-)-儿茶素没食子酸酯 (-)-儿茶素没食子酸酯, 来源于绿茶 (2S,3R)-2-(3,4-二羟苯基)-3,4-二氢-1(2H)-苯并-3,5,7-三醇3-(3,4,5-三羟基苯甲酸)
英文别名	Catechin gallate (-)-Catechin gallate(CG) (-)-Catechin 3-O-gallate) Choriogonadotropin subunit β Chorionic gonadotrophin chain β ANTI-CG antibody produced in mouse Catechin gallate CG (-)-Catechin gallate (-)-Catechin gallate ((-)-Catechin 3-gallate Anti-HCG β, C-Terminal antibody produced in rabbit
CAS	130405-40-2
化学式	C22H18O10
分子量	442.37
InChIKey	LSHVYAFMTMFKBA-CTNGQTDRSA-N
密度	1.80±0.1 g/cm3(Predicted)
熔点	248-251 °C (decomp)
沸点	861.7±65.0 °C(Predicted)
溶解度	DMSO (微溶) 、乙醇 (微溶)
酸度系数	7.75±0.25(Predicted)
存储条件	2-8°C
外观	固体
颜色	Pale Yellow to Light Red
物化性质	白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于绿茶。
MDL号	MFCD00214258
体外研究	(-)-Catechin gallate (CG) directly interacts with DNA oligomers and inhibits the activity of COX-1 and COX-2 enzymes, the gene expression of matrix metalloproteinase-9 in macrophage-differentiated HL-60 myeloid leukemia cells, the adipocyte uptake of glucose by the transporter, GLUT4, and the activities of various proteasomes, i.e., the multicatalytic proteases responsible for the degradation of most cellular proteins. The relative cytotoxicities of a 3-day exposure to (-)-Catechin gallate are determined for cancerous CAL27 and HSG cells, immortalized epithelioid S-G cells, and normal HGF-1 gingival fibroblasts. The concentration at which toxicity (P≤0.01) initially occur is 25 μM (-)-Catechin gallate for S-G cells, 50 μM (-)-Catechin gallate for CAL27 cells, 62.5 μM (-)-Catechin gallate for HSG cells and 75 μM (-)-Catechin gallate for HGF-1 fibroblasts. The calculated neutral red (NR 50 ) values for a 3-day exposure to (-)-Catechin gallate are 58 μM for S-G cells, 62 μM for CAL27 cells, 90 μM for HSG cells and 132 μM for HGF-1 fibroblasts.
危险品标志	Xi - 刺激性物品
风险术语	36/37/38 - 刺激眼睛、呼吸系统和皮肤。
安全术语	S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。
WGK Germany	3
海关编号	29329990
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儿茶素没食子酸酯 - 简介

儿茶素没食子酸酯（Epicatechin gallate）是一种化合物，属于茶多酚类化合物。它是茶叶中的主要成分之一，尤其是绿茶中含量较高。

儿茶素没食子酸酯具有抗氧化、抗炎、抗菌和抗癌等多种生理活性。儿茶素没食子酸酯还具有抗糖尿病和降低胆固醇等作用。

制取儿茶素没食子酸酯一般采用提取和结晶方法。通过将茶叶浸泡在适当的溶剂中，如乙醇，来提取茶叶中的茶多酚类化合物。然后，通过过滤和浓缩过程将提取液中的杂质去除，获得所需的儿茶素没食子酸酯溶液。通过结晶过程将溶液中的儿茶素没食子酸酯结晶出来。

儿茶素没食子酸酯在一般情况下被认为是安全的。在使用过程中仍应注意适量饮用，避免过量摄入而引起不适。对于儿童、孕妇和哺乳期妇女，应遵医嘱使用。个别人群可能对儿茶素没食子酸酯过敏，在使用之前应先进行适度的皮肤敏感性测试。

最后更新：2024-04-09 21:01:54

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