化合物AZD5305
AZD5305(AZD5305)
CAS: 2589531-76-8
化学式: C22H26N6O2
| 中文名 | AZD5305 |
| 英文名 | AZD5305 |
| 别名 | 化合物AZD5305 5-[4-[(7-乙基-6-氧代-5,6-二氢-1,5-萘啶-3-基)甲基]-1-哌嗪基]-N-甲基吡啶-2-甲酰胺 5-[4-[(7-乙基-5,6-二氢-6-氧代-1,5-萘啶-3-基)甲基]-1-哌嗪基]-N-甲基-2-吡啶甲酰胺 |
| 英文别名 | AZD5305 AZD-5305 5-[4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methylpicolinamide 2-Pyridinecarboxamide, 5-[4-[(7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methyl- |
| CAS | 2589531-76-8 |
| 化学式 | C22H26N6O2 |
| 分子量 | 406.48 |
| 溶解度 | 溶于DMSO |
| 存储条件 | -20℃ |
| 产品用途 | AZD5305 is a potent, selective and oral active PARP inhibitor. AZD5305 is a highly potent inhibitor of PARP1, with significant PARP1-DNA trapping activity, no PARP2-activity, nor binding activity to any other members of the PARP family. AZD5305 has excellent secondary pharmacology and physicochemical properties as well as high oral bioavailability in preclinical species. |
| 靶点 | PARP |
化合物AZD5305 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.46 ml | 12.3 ml | 24.601 ml |
| 5 mM | 0.492 ml | 2.46 ml | 4.92 ml |
| 10 mM | 0.246 ml | 1.23 ml | 2.46 ml |
| 5 mM | 0.049 ml | 0.246 ml | 0.492 ml |
最后更新：2024-01-02 23:10:35
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