化合物ICA069673_化工百科

中文名	ICA-069673
英文名	ICA-069673
别名	化合物ICA069673 N-(2-氯-5-嘧啶基)-3,4-二氟苯甲酰胺
英文别名	ICA069673 ICA-069673 ICA 069673 N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-
CAS	582323-16-8
化学式	C11H6ClF2N3O
分子量	269.63
密度	1.539±0.06 g/cm3(Predicted)
沸点	358.9±37.0 °C(Predicted)
溶解度	DMSO : ≥ 34 mg/mL (126.10 mM)
酸度系数	9.47±0.70(Predicted)
存储条件	Sealed in dry,Room Temperature
体外研究	ICA-069673 is found to be 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5 and has no measurable activity against a panel of cardiac ion channels (IC 50 values > 30 μM for hERG, Nav1.5, L type channels, and KCNQ1) as well as no activity on GABA(A) gated channels at 10 μM. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, an 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3. Based on ICA73 sensitivity of chimeric constructs of the transmembrane segments of KCNQ2 and KCNQ3, this drug appears to interact with the KCNQ2 voltage sensor (S1-S4).
参考资料展开查看	1: Provence A, Malysz J, Petkov GV. The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. J Pharmacol Exp Ther. 2015 Sep;354(3):290-301. doi: 10.1124/jpet.115.225268. Epub 2015 Jun 18. PubMed PMID: 26087697; PubMed Central PMCID: PMC4538873. 2: Vicente-Baz J, Lopez-Garcia JA, Rivera-Arconada I. Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology. 2016 Oct;109:131-8. doi: 10.1016/j.neuropharm.2016.05.025. Epub 2016 Jun 2. PubMed PMID: 27263036. 3: Brueggemann LI, Haick JM, Cribbs LL, Byron KL. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol Pharmacol. 2014 Sep;86(3):330-41. doi: 10.1124/mol.114.093799. Epub 2014 Jun 18. PubMed PMID: 24944189; PubMed Central PMCID: PMC4152906. 4: Wang AW, Yang R, Kurata HT. Sequence determinants of subtype-specific actions of KCNQ channel openers. J Physiol. 2017 Feb 1;595(3):663-676. doi: 10.1113/JP272762. Epub 2016 Sep 23. PubMed PMID: 27506413; PubMed Central PMCID: PMC5285613.

化合物ICA069673 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.709 ml	18.544 ml	37.087 ml
5 mM	0.742 ml	3.709 ml	7.417 ml
10 mM	0.371 ml	1.854 ml	3.709 ml
5 mM	0.074 ml	0.371 ml	0.742 ml

最后更新：2024-01-02 23:10:35

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CAS: 582323-16-8
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产品名: N-(2-氯-5-嘧啶基)-3,4-二氟苯甲酰胺去供应商网站查看询盘
CAS: 582323-16-8
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产品描述: 中文名：N-(2-氯-5-嘧啶基)-3,4-二氟苯甲酰胺英文名:ICA-069673 CAS:582323-16-8 规格:98% 产地:中国上海

上海麦克林生化科技股份有限公司

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产品名: ICA-069673 去供应商网站查看询盘
CAS: 582323-16-8
产地: 上海
规格: I878339
价格: 5mg-489,10mg-770,50mg-2443,100mg-3504,1ml-195
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产品名: ICA-069673 去供应商网站查看询盘
CAS: 582323-16-8
产地: 上海
规格: 98%
价格: 5mg 496,10mg 880,25mg 1440,100mg 4480
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