化合物NVP-ACC789_化工百科

中文名	N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺
英文名	ACC-789
别名	化合物NVP-ACC789 N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺 N-(3-溴-4-甲基苯基)-4-(吡啶-4-基甲基)酞嗪-1-胺
英文别名	ACC789 ACC-789 Acc-789 ACC 789 ZK 202650 ZK-202650 NVP-ACC-789 NVP-ACC-789 ACC-789 (NVP-ACC789) N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
CAS	300842-64-2
化学式	C21H17BrN4
分子量	405.29
密度	1.441
存储条件	Room Temprature
体外研究	The enzymatic kinase assays demonstrate that NVP-ACC789 is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC 50 s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively. In VEGF-treated cultures, addition of the VEGFR-2 inhibitor NVP-ACC789 reduces BME cell number to baseline levels from 1 μM. Likewise, bFGF-induced BME cell proliferation is reduced markedly by NVP-ACC789 from 1 to 10 μM, without however reaching basal levels. NVP-ACC789 is found to be a potent inhibitor of VEGF-induced HUVE cell proliferation with an IC 50 of 1.6 nM. NVP-ACC789 also completely inhibits VEGF-induced BME and BAE cell invasion and VEGF-C-induced BAE cell invasion. The inhibition is dose-dependent in both cell types with a maximal effect from 1 μM.
体内研究	NVP-ACC789 which is given in daily oral doses for 6 days blocks VEGF-induced angiogenesis in a dose-dependent manner. NVP-ACC789 also inhibits the response to bFGF to some extent, but the dose-response curve is not linear for NVP-ACC789.

北京索莱宝科技有限公司

产品名: NVP-ACC789 去供应商网站查看询盘
CAS: 300842-64-2
产地: 北京
包装: 1mg /瓶
规格: IN4630-1mg
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上海吉至生化科技有限公司

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产品名: N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺去供应商网站查看询盘
CAS: 300842-64-2
产地: 中国上海
包装: 50mg
规格: 99%
价格: 1898.00
库存: 现货
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产品描述: 中文名：N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺英文名:NVP-ACC789 CAS:300842-64-2 规格:99% 产地:中国上更多

上海麦克林生化科技股份有限公司

现货供应

产品名: NVP-ACC789 去供应商网站查看询盘
CAS: 300842-64-2
产地: 上海
规格: N879733
价格: 5mg-204,25mg-483,500mg-5878,10mg-326,50mg-839
库存: 7天内发货
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上海源叶生物科技有限公司

产品名: N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺去供应商网站查看询盘
CAS: 300842-64-2
产地: 上海
价格: 2mg 680,5mg 1230,10mg 1700,25mg 4080
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