化合物UK371804
UK-371804(UK-371804)
CAS: 256477-09-5
化学式: C14H16ClN5O4S
| 中文名 | UK-371804 |
| 英文名 | UK-371804 |
| 别名 | 化合物UK371804 |
| 英文别名 | UK-371804 Urokinase inhibitor 1 Urokinase inhitibor 1 UK-371804 (Urokinase inhitibor 1) N-[[1-[(Aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methylalanine Alanine, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl- |
| CAS | 256477-09-5 |
| 化学式 | C14H16ClN5O4S |
| 分子量 | 385.83 |
| 溶解度 | DMSO: 10 mg/mL |
| 存储条件 | -20℃ |
| 体外研究 | UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC 50 =0.89 μM). UK-371804 has its excellent enzyme potency (K i =10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). |
| 体内研究 | In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM. |
化合物UK371804 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.592 ml | 12.959 ml | 25.918 ml |
| 5 mM | 0.518 ml | 2.592 ml | 5.184 ml |
| 10 mM | 0.259 ml | 1.296 ml | 2.592 ml |
| 5 mM | 0.052 ml | 0.259 ml | 0.518 ml |
最后更新：2024-01-02 23:10:35
供应商列表
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！