坎普他汀_化工百科

中文名	COMPSTATIN
英文名	Compstatin
别名	坎普他汀化合物COMPSTATIN COMPSTATIN游离态
英文别名	COMPSTATIN Compstatin H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2, (Disulfide bond) Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt (Disulfide bond) L-Threoninamide, L-isoleucyl-L-cysteinyl-L-valyl-L-valyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-histidyl-L-histidyl-L-arginyl-L-cysteinyl-, cyclic (2→12)-disulfide
CAS	206645-99-0
化学式	C66H99N23O17S2
分子量	1550.77
存储条件	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
体外研究	Compstatin exhibits an in vitro half-life in human blood of about2 hr. In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster.
体内研究	Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures. Compstatin is stable in baboon plasma for more than 24 h. Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group. Animal Model: Juvenile baboons ( P. Anubis ) weighing 10.5-28.8 kg. Dosage: 50, 25 mg/kg 60 min after heparin and 2 min before protamine. Administration: A bolus injection. Result: Completely inhibited complement activation induced by heparin–protamine complexes.

坎普他汀 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	0.645 ml	3.224 ml	6.448 ml
5 mM	0.129 ml	0.645 ml	1.29 ml
10 mM	0.064 ml	0.322 ml	0.645 ml
5 mM	0.013 ml	0.064 ml	0.129 ml

最后更新：2024-01-02 23:10:35

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