大黄素-8-Β-D-葡萄糖苷

中文名	大黄素-8-β-D-吡喃葡萄糖苷
英文名	Emodin-8-glucoside
别名	蒽甙B 大黄素-8-O-葡萄糖苷大黄素-8-Β-D-葡萄糖苷大黄素-8-Β-D-吡喃葡萄糖苷大黄素-8-β-D-吡喃葡萄糖苷大黄酚-8-0-Β-D-葡萄糖苷大黄素-8-O-Β-D-葡萄糖苷大黄素-8-O-Β-D-吡喃葡萄糖苷 EMODIN-8-GLUCOSIDE 大黄素-8-Β-D-吡喃葡萄糖苷
英文别名	Emodin 1-glucoside Emodin glucoside B Emodin-8-glucoside EModin 8-β-D-Glucoside 8-O-β-D-Glucopyranosylemodin EModin-8-O-β-D-glucopyranoside 8-(β-D-Glucopyranosyloxy)-1,6-dihydroxy-3-methylanthraquinone 1,6-Dihydroxy-3-methyl-8-(β-D-glucopyranosyloxy)-9,10-anthraquinone 1-(β-D-Glucopyranosyloxy)-3,8-dihydroxy-6-methylanthracene-9,10-dione
CAS	23313-21-5
化学式	C21H20O10
分子量	432.38
密度	1.667±0.06 g/cm3(Predicted)
熔点	219-220 °C
沸点	798.7±60.0 °C(Predicted)
溶解度	DMSO (微溶)，甲醇 (微溶，加热)，水 (微溶)
酸度系数	6.27±0.20(Predicted)
存储条件	2-8°C(protect from light)
外观	固体
颜色	Yellow to Brown
物化性质	淡黄色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于何首乌，蓼科植物掌叶大黄的干燥根及根茎。
MDL号	MFCD01725365
海关编号	29389090
参考资料展开查看	1. 罗益远刘娟秀刘廷等. UPLC-MS/MS法同时测定何首乌中二苯乙烯蒽醌黄酮及酚酸类成分[J]. 质谱学报 2016(4):327-335. 2. 侯文文石燕红宋嬿等. 一测多评法同步测定何首乌中4种蒽醌类成分的含量[J]. 中国中药杂志 2020 v.45(01):141-149. 3. 张语凡王蕾王鑫等. 何首乌不同炮制时间与方式的薄层特征图谱鉴别[J]. 中华中医药杂志 2018 v.33(11):408-411. 4. 王靖越张语凡柴冲冲等. 何首乌饮片的颜色与蒽醌类和二苯乙烯苷含量的相关性研究[J]. 中南药学 2020(4). 5. 罗益远刘娟秀刘训红等. 同基源何首乌和首乌藤化学成分含量分析[J]. 天然产物研究与开发 2016 28(7):1035-1044. 6. 汪祺, 张茜蕙, 文海若,等. 基于肝微组织考察何首乌主要单体潜在肝毒性[J]. 中国中药杂志, 2020, v.45(12):236-241. 7. 敏,张志,李听弦,陶彩霞,贾平,王光忠.大黄煨制前后HPLC指纹图谱的比较研究[J].时珍国医国药,2020,31(06):1361-1364. 8. 吴嫣艳,任会旭,冯友龙,张莉,张妤琳.安神补脑胶囊HPLC指纹图谱与3种成分含量测定方法研究[J].广东药科大学学报,2020,36(06):778-783. 9. 汪颖舒,朱广灏,王冰,李杰荣,骆前飞,何修滢,赵佳逸,修彦凤.古法黑豆蒸晒与药典黑豆汁连续蒸对何首乌中12个成分含量的影响[J].中草药,2020,51(19):4972-4982. 10. Lin, Longfei, et al. "Application of iTRAQ-based quantitative proteomics approach to identify deregulated proteins associated with liver toxicity induced by polygonum multiflorum in rats." Cellular Physiology and Biochemistry 43.5 (2017): 2102-2116.https:/ 11. Lin, Longfei et al. “A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor.” Frontiers in pharmacology vol. 8 349. 20 Jun. 2017, doi:10.3389/fphar. 12. Lin, Longfei, et al. "Hepatotoxicity and mechanism study of chrysophanol-8-O-glucoside in vitro." Biomedicine & Pharmacotherapy 120 (2019): 109531.https://doi.org/10.1016/j.biopha.2019.109531 13. [IF=10.588] Longfei Lin et al."A novel method to analyze hepatotoxic components in Polygonum multiflorum using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry."J Hazard Mater. 2015 Dec;299:249 14. [IF=5.81] Zhang Miao et al."Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats."Front Pharmacol. 2018 May;0:505 15. [IF=5.81] Lin Longfei et al."A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor."Front Pharmacol. 2017 Jun;0:349 16. [IF=5.645] Fangyuan Gao et al."Cyclodextrin-based ultrasonic-assisted microwave extraction and HPLC-PDA-ESI-ITMSn separation and identification of hydrophilic and hydrophobic components of Polygonum cuspidatum: A green, rapid and effective process."Ind Crop Prod. 20 17. [IF=4.379] Wang Qi et al."Identification and characterization of the structure–activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum."Sci Rep-Uk. 2017 Dec;7(1):1-9 18. [IF=3] Juan HUANG et al."Chemical profiles and metabolite study of raw and processed Polygoni Multiflori Radix in rats by UPLC-LTQ-Orbitrap MSn spectrometry."Chin J Nat Medicines. 2018 May;16:375 19. [IF=1.902] Longfei Lin et al."Simultaneous determination of 14 constituents of Radix polygoni multiflori from different geographical areas by liquid chromatography–tandem mass spectrometry."Biomed Chromatogr. 2015 Jul;29(7):1048-1055 20. [IF=1.902] Longfei Lin et al."Characterization of the constituents in rat plasma after oral administration of radix polygoni multiflori extracts by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry."Biomed Chromatogr. 2015 Oct;29(10 21. [IF=0] Longfei Lin et al."Application of iTRAQ-Based Quantitative Proteomics Approach to Identify Deregulated Proteins Associated with Liver Toxicity Induced by Polygonum Multiflorum in Rats."Cell Physiol Biochem. 2017;43(5):2102-2116 22. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 23. [IF=3.935] Yanchao Xing et al."An effective strategy for distinguishing the processing degree of Polygonum multiflorum based on the analysis of substance and taste by LC-MS, ICP-OES and electronic tongue."J Pharmaceut Biomed. 2021 Oct;205:114328 24. [IF=3.743] Longfei Lin et al."Hepatotoxicity and mechanism study of chrysophanol-8-O-glucoside in vitro."Biomed Pharmacother. 2019 Dec;120:109531 25. [IF=5.645] Huilan Yue et al."Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities."Ind Crop Prod. 2022 Apr;178:114595 26. [IF=5.811] Kong Wei-Song et al."Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury."Front Pharmacol. 2022 Apr;0:928

大黄素-8-Β-D-葡萄糖苷 - 简介

性质:
1、是一种白色至淡黄色结晶性粉末，易溶于热水和热乙醇，微溶于乙醇和乙醚，几乎不溶于乙酸乙酯。
2、具有抗炎、抗菌、抗肿瘤等药理活性。

制法:
主要是从大黄素(Emodin)或大黄提取物中提取得到。一种典型的制备方法是采用柱层析技术分离提纯。

安全信息:
1、避免接触皮肤和吸入粉末。
2、需要保存在密封的容器中，避免阳光直射。

最后更新：2024-06-06 11:02:29

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产品描述: 中文名：大黄素-8-β-D-吡喃葡萄糖苷英文名:Emodin-8-beta-D-Glucoside CAS:23313-21-5 规格:98% 产地:中国上海

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