富玛酸卢帕他定

中文名	富马酸卢帕他定
英文名	Rupatadine fumarate
别名	富马酸泸帕他富玛酸卢帕他定富马酸鲁帕他定富马酸卢帕他定富马酸泸帕他定 8-氯-6,11-二氢-11-[1-[(5-甲基-3-吡啶基)甲基]-4-哌啶亚基]-5H-苯并[5,6]环庚烷并[1,2-B] 8-氯-11-(1-((5-甲基吡啶-3-基)甲基)哌啶-4-亚基)-6,11-二氢-5H-苯并[5,6]环庚[1,2-B]吡啶富马酸盐 8-氯-6,11-二氢-11-[1-[(5-甲基-3-吡啶基)甲基]-4-哌啶亚基]-5H-苯并[5,6]环庚烷并[1,2-b]吡啶富马酸盐
英文别名	Rupax FuMarate Rupafin FuMarate Pafinur FuMarate Rinialer FuMarate Rupatadine Fumarate RUPATADINE FUMARATE Rupatadine fumarate Alergoliber FuMarate 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine fumarate 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidylidene]-5h-benzo[5,6]cyclohepta[1,2-b]pyridine fumarate
CAS	182349-12-8
EINECS	1592732-453-0
化学式	C26H26ClN3.C4H4O4
分子量	532.03
InChI	InChI=1/C26H26ClN3.C4H4O4/c1-18-13-19(16-28-15-18)17-30-11-8-20(9-12-30)25-24-7-6-23(27)14-22(24)5-4-21-3-2-10-29-26(21)25;5-3(6)1-2-4(7)8/h2-3,6-7,10,13-16H,4-5,8-9,11-12,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
熔点	196-198°C
溶解度	甲醇 (微溶加热)
存储条件	Sealed in dry,2-8°C
外观	固体
颜色	White to Pale Brown
体外研究	Rupatadine inhibits both platelet-activating factor (PAF) and histamine (H1) effects through its interaction with specific receptors. Rupatadine competitively inhibits histamine-induced guinea pig ileum contraction (pA2 = 9.29 ?0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4(LTD4). It also competitively inhibits PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2= 6.68 ± 0.08) and in human platelet-rich plasma (HPRP) (IC50 = 0.68 μM), while not affecting ADP- or arachidonic acid-induced platelet aggregation. In another study, it is reported rupatadine and loratadine shows similar inhibitory effect on histamine and TNF-α release, whereas SR-27417A only exhibits inhibitory effect against TNF-α.
体内研究	Rupatadine blocks histamine- and PAF-induced effects in vivo, such as hypotension in rats (ID50 = 1.4 and 0.44 mg/kg i.v., respectively) and bronchoconstriction in guinea pigs (ID50 = 113 and 9.6 μg/kg i.v.). Moreover, it potently inhibits PAF-induced mortality in mice (ID50 = 0.31 and 3.0 mg/kg i.v. and p.o., respectively) and endotoxin-induced mortality in mice and rats (ID50 = 1.6 and 0.66 mg/kg i.v.). Rupatadine's duration of action is long, as assessed by the histamine- and PAF-induced increase in vascular permeability test in dogs (42 and 34% inhibition at 26 h after 1 mg/kg p.o.). Rupatadine at a dose of 100 mg/kg p.o. neither modifies spontaneous motor activity nor prolongs barbiturate-sleeping time in mice, which indicates a lack of sedative effects.

富玛酸卢帕他定 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.88 ml	9.398 ml	18.796 ml
5 mM	0.376 ml	1.88 ml	3.759 ml
10 mM	0.188 ml	0.94 ml	1.88 ml
5 mM	0.038 ml	0.188 ml	0.376 ml

最后更新：2024-01-02 23:10:35

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产品名: 8-氯-11-(1-((5-甲基吡啶-3-基)甲基)哌啶-4-亚基)-6,11-二氢-5H-苯并[5,6]环庚[1,2-b]吡啶富马酸盐去供应商网站查看询盘
CAS: 182349-12-8
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产品描述: 中文名：富马酸卢帕他定英文名:Rupatadin Fumarate CAS:182349-12-8 规格:98% 产地:中国上海

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