中文名 | 射干苷 |
英文名 | Tectoridin |
别名 | 射干苷 鹫尾苷 鸢尾黄酮苷 鸢尾黄酮甙 哈巴苷(分析标准品) 射干苷(分析标准品) TECTORIDIN 鸢尾苷 TECTORIDIN 鸢尾苷 标准品 |
英文别名 | Shekkanin Tectoridin TectoridinI TECTORIDIN (RG) Tectorigenin 7-glucoside Tectorigenin 7-O-β-D-glucopyranoside Tectoridin [Tectorigenin 7-glucoside, Shekanin] D-Glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one 5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside 5-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one |
CAS | 611-40-5 |
化学式 | C22H22O11 |
分子量 | 462.4 |
InChI | InChI=1/C22H22O11/c1-30-21-13(32-22-20(29)19(28)17(26)14(7-23)33-22)6-12-15(18(21)27)16(25)11(8-31-12)9-2-4-10(24)5-3-9/h2-6,8,14,17,19-20,22-24,26-29H,7H2,1H3/t14-,17-,19+,20-,22-/m1/s1 |
密度 | 1.609±0.06 g/cm3(Predicted) |
熔点 | 256-258° |
沸点 | 798.1±60.0 °C(Predicted) |
比旋光度 | D20 -29.4° (pyridine) |
闪点 | 279.7°C |
蒸汽压 | 7.19E-27mmHg at 25°C |
溶解度 | 溶于甲醇 |
折射率 | 1.694 |
酸度系数 | 6.10±0.20(Predicted) |
存储条件 | Inert atmosphere,2-8°C |
外观 | 整洁 |
颜色 | White to Almost white |
物化性质 | 白色结晶粉末,溶于甲醇,来源于射干,鸢尾。 |
MDL号 | MFCD04039835 |
体外研究 | Tectoridin scarcely binds to ER alpha as compared to 17beta-estradiol and genistein. Tectoridin induceds potent estrogenic effects, namely recovery of the population of cells in the S-phase after serum starvation, transactivation of the estrogen response element, and induction of MCF-7 cell proliferation. Tectoridin induces estrogenic effect, and this effect is severely abrogated by treatment with U0126 ( MEK1/2 inhibitor). Tectoridin promotes phosphorylation of ERK1/2, but does not affect phosphorylation of ER alpha at Ser (118). It also increases cellular accumulation of cAMP. |
WGK Germany | 3 |
RTECS | DJ3090000 |
海关编号 | 29389090 |
参考资料 展开查看 | 1. 曾慧婷, 陈超, 禇怀亮,等. 粉葛资源产业化过程废弃物中的黄酮类化学成分分析[J]. 中国药房, 2020, v.31;No.670(04):72-77. 2. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 3. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 4. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884 5. [IF=3.645] Wenjie Wu et al."Simple, rapid, and environmentally friendly method for the separation of isoflavones using ultra-high performance supercritical fluid chromatography."J Sep Sci. 2017 Jul;40(13):2827-2837 6. [IF=6.922] Zhen-Hua Ying et al."Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways."J Inflamm Res. 2021; 14: 341–354 7. [IF=4.769] Jing Han et al."Qualitative and quantitative evaluation of Flos Puerariae by using chemical fingerprint in combination with chemometrics method."J Pharm Anal. 2021 Sep;: 8. [IF=4.759] Wenjie Wu et al."An analytical strategy for accurate, rapid and sensitive quantitative analysis of isoflavones in traditional Chinese medicines using ultra-high performance supercritical fluid chromatography: Take Radix Puerariae as an example."J Chromato 9. [IF=3.645] Ziyun Wei et al.Studies on chemical constituents of Flos Puerariae-Semen Hoveniae medicine pair by HPLC and Fourier transform ion cyclotron resonance mass spectrometry.Journal Of Separation Science.2021 Nov 06 |
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