曲札茋苷
曲札茋苷(Piceatannol3'-O-glucoside)
CAS: 94356-26-0
化学式: C20H22O9
| 中文名 | 曲札茋苷 |
| 英文名 | Piceatannol3'-O-glucoside |
| 别名 | 曲札芪苷 曲札茋苷 白皮杉醇-3'-O-葡萄糖苷 反式-白皮杉醇-3-O-葡萄糖苷 白皮杉醇-3'-O-葡萄糖苷对照品 白皮杉醇-3'-O-葡萄糖苷标准品 |
| 英文别名 | Quzhaqigan Piceatannol 3-glycoside Piceatannol3'-O-glucoside Piceatannol 3'-O-glucoside trans-Piceatannol 3-glucoside Piceatannol 3'-O-beta-D-glucopyranoside 3,5,3',4'-trihydroxy-stilbene -3'-b-D-glucoside β-D-Glucopyranoside, 5-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-2-hydroxyphenyl (E)-1-(3,5-dihydroxyphenyl)-2-(3-hydroxy-4-O-β-D-glucopyranose phenyl)ethylene |
| CAS | 94356-26-0 |
| 化学式 | C20H22O9 |
| 分子量 | 406.38 |
| 密度 | 1.593±0.06 g/cm3(Predicted) |
| 熔点 | >219°C (dec.) |
| 沸点 | 721.6±60.0 °C(Predicted) |
| 溶解度 | DMSO (微溶)，乙醇 (微溶，超声处理)，甲醇 (微溶) |
| 酸度系数 | 9.16±0.10(Predicted) |
| 存储条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| MDL号 | MFCD28100371 |
| 体外研究 | Piceatannol 3'-O-glucoside (Piceatannol-3'-O-β-D-glucopyranoside; PG) is a potent component of stilbenes, inhibits the activity of arginase I and II prepared from mouse liver and kidney lysates, respectively, in a dose-dependent manner. In human umbilical vein endothelial cells, incubation of Piceatannol 3'-O-glucoside markedly blocks arginase activity and increases nitrite and nitrate (NOx) production, as measured by Griess assay. In liver lysates, incubation of different concentrations of Piceatannol 3'-O-glucoside significantly decreases arginase I activity (75±5% at 1 µM, 72±7% at 3 µM, 62±1% at 10 µM) compared to untreated control (100±9%). In kidney lysates, the residual arginase activities after incubation of 1, 3 and 10 µM Piceatannol 3'-O-glucoside are 75±6, 74±5, and 53±8%, respectively. Arginase activity is measured in the presence of different concentration of Piceatannol 3'-O-glucoside (from 0 to 120 µM) using liver lysate and kidney lysate. The 50% inhibitory concentrations (IC 50 ) are 11.22 µM for the liver lysate and 11.06 µM for kidney lysate. The values are obtained using the software of Graphpad prizm 4.0. Piceatannol 3'-O-glucoside inhibits arginase activity and increases NO production in HUVECs. Piceatannol 3'-O-glucoside inhibits lipoxygenase activity upto 66% at the concentration of 100 µM and IC 50 value is 69 µM. |
| 体内研究 | In order to ascertain whether Piceatannol 3'-O-glucoside (PG) ameliorates vascular function in wild-type (WT) and atherogenic model mice [apolipoprotein E-null mice (ApoE -/- )] and to investigate the possible underlying mechanism. Preincubation of aortic vessels from WT mice fed a normal diet (ND) with Piceatannol 3'-O-glucoside attenuates vasoconstriction response to U46619 and phenylephrine (PE), while the vasorelaxant response to acetylcholine (Ach) is markedly enhanced in an endothelium-dependent manner. Piceatannol 3'-O-glucoside treatment attenuates the phenylephrine (PE)-dependent contractile response, and significantly improves the acetylcholine (Ach)-dependent vasorelaxation response in aortic rings from ApoE -/- mice fed a high-cholesterol diet (HCD). Piceatannol 3'-O-glucoside administration in the drinking water significantly reduces fatty streak formation in ApoE -/- mice fed an HCD. |
| 参考资料 展开查看 | 1. 孙玉明, 柴洪杰, 张华,等. 高效液相色谱法测定曲札茋苷原料药的含量及有关物质[J]. 中南药学, 2020, v.18;No.169(02):76-79. |
曲札茋苷 - 简介
曲札茋苷是一种天然产物，主要存在于葡萄酒和红茶中。它属于一类称为黄酮类化合物的植物次生代谢产物。
曲札茋苷有着多种重要的生物学和药理学活性，包括抗氧化、抗炎症和抗肿瘤等作用。它还具有保护心血管系统、改善记忆力和促进骨骼健康的效果。
曲札茋苷的制法可以通过提取葡萄皮、茶叶或其他富含该化合物的植物材料来进行。提取物经过纯化和结晶等工艺步骤，最终得到纯度较高的曲札茋苷。
在使用曲札茋苷时应注意其安全性。它是一种天然产物，一般认为对人体无毒副作用。如有必要，使用前请阅读相关产品的说明书和标签，按照指导使用。
曲札茋苷有着多种重要的生物学和药理学活性，包括抗氧化、抗炎症和抗肿瘤等作用。它还具有保护心血管系统、改善记忆力和促进骨骼健康的效果。
曲札茋苷的制法可以通过提取葡萄皮、茶叶或其他富含该化合物的植物材料来进行。提取物经过纯化和结晶等工艺步骤，最终得到纯度较高的曲札茋苷。
在使用曲札茋苷时应注意其安全性。它是一种天然产物，一般认为对人体无毒副作用。如有必要，使用前请阅读相关产品的说明书和标签，按照指导使用。
最后更新：2024-04-09 20:52:54
供应商列表
现货供应
产品名: 白皮杉醇3'-O-葡萄糖苷 去供应商网站查看 询盘CAS: 94356-26-0
产地: 上海
规格: P876250
价格: 25mg-3826,10mg-1897,5mg-999
库存: 15天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: 白皮杉醇3'-O-葡萄糖苷 去供应商网站查看 询盘CAS: 94356-26-0
产地: 上海
规格: P876250
价格: 25mg-3826,10mg-1897,5mg-999
库存: 15天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
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