更昔洛韦钠原料药
更昔洛韦钠(Ganciclovir sodium)
CAS: 107910-75-8
化学式: C9H12N5NaO4
| 中文名 | 更昔洛韦钠 |
| 英文名 | Ganciclovir sodium |
| 别名 | 更昔洛韦钠 注射更昔洛韦 更昔洛韦杂质7 更昔洛韦钠原料药 更昔洛韦钠(二水) 更昔洛韦钠[干冰运输,需加收额外费用] 9-(1,3-二羟基-2-丙氧甲基)-鸟嘌呤钠 |
| 英文别名 | Unii-02L083W284 Rs 21592 sodium Ganciclovir sodium GANCICLOVIR SODIUM Ganciclovir monosodium salt 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-3,9-dihydro-6H-purin-6-one sodium 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-olate 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6h-purin-6-one sodium salt 6H-Purin-6-one, 1,9-dihydro-2-amino-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, monosodium salt 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, monosodium salt |
| CAS | 107910-75-8 |
| EINECS | 641-368-8 |
| 化学式 | C9H12N5NaO4 |
| 分子量 | 277.21 |
| InChI | InChI=1/C9H14N5O4.Na/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16;/h3,5,8,15-16H,1-2,4H2,(H3,10,12,13);/q-1;+1 |
| 存储条件 | 2-8℃ |
| 体外研究 | Ganciclovir sodium is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 mumol versus 72 mumol for acyclovir.The primary mechanism of ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir sodium is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase. |
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