中文名 | 柠檬苦素 |
英文名 | limonin from citrus seeds |
别名 | 柠碱 柠檬苦素 檸檬苦素 LIMONIN 柠檬苦素 柠檬苦素,黄柏内酯(橙皮提取) 吴茱萸内酯(标准品,吴茱萸提取) LIMONIN 柠檬苦素 标准品 |
英文别名 | LiMone Evodin Lemonin Limonin Limonine NSC 36508 AI3-37932 CCRIS 4047 Citrolimonin Obaculactone Lemon bitter Evodia lactone Dictamnolactone limonin from citrus seeds Limonoic acid, di-delta-lactone 7,16-Dioxo-7,16-dideoxylimondiol LiMonin, froM TetradiuM ruticarpuM LiMonin SynonyMs LiMonoate D-ring-lactone |
CAS | 1180-71-8 |
化学式 | C26H30O8 |
分子量 | 470.51 |
InChI | InChI=1/C26H30O8/c1-22(2)15-9-16(27)24(4)14(25(15)12-31-18(28)10-17(25)33-22)5-7-23(3)19(13-6-8-30-11-13)32-21(29)20-26(23,24)34-20/h6,8,11,14-15,17,19-20H,5,7,9-10,12H2,1-4H3/t14-,15-,17-,19-,20+,23-,24-,25+,26+/m0/s1 |
密度 | 1.39±0.1 g/cm3(Predicted) |
熔点 | 298 C |
沸点 | 67 °C |
比旋光度 | D -128° (c = 1.21 in acetone) |
闪点 | 358°C |
蒸汽压 | 9.96E-18mmHg at 25°C |
溶解度 | 氯仿 (微溶),DMSO (微溶) |
折射率 | 1.602 |
存储条件 | 2-8°C |
外观 | 整洁 |
颜色 | White to Off-White |
最大波长(λmax) | 285nm(lit.) |
Merck | 14,5494 |
物化性质 | 易于溶酯性有机溶剂,难溶于水,在甲醇、乙醇中溶解度较大。 来源于芸香科植物枳实柚的果实。 |
MDL号 | MFCD00075922 |
危险品标志 | Xn - 有害物品![]() |
风险术语 | 20/21/22 - 吸入、皮肤接触及吞食有害。 |
安全术语 | S36 - 穿戴适当的防护服。 S24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
RTECS | RR1122000 |
海关编号 | 29321900 |
参考资料 展开查看 | 1. 冯昕 赵文军 侯婷 等. UPLC-MS/MS测定二妙散提取物中14种成分的含量[J]. 中国实验方剂学杂志 2017 023(021):79-85. 2. 许杭琳 邓刚 焦聪聪 等. 佛手饮料废渣中分离柠檬苦素的研究[J]. 浙江师范大学学报(自然科学版) 2012(03):322-325. 3. 张红梅 李国 宋龙 等. 吴茱萸与伪品臭辣树果实的生药学鉴定[J]. 中药材 2016(3期):515-518. 4. 刘旭颖, 王纹岚, 葛朝晖,等. 基于优化显微定量法的吴茱萸质量评价[J]. 中国现代中药, 2018, 20(05):561-564. 5. 孙小雯, 彭颖, 何婉莺,等. 星点设计-效应面法优化枳雀内果皮柠檬苦素提取工艺[J]. 食品工业科技, 2018, v.39;No.402(10):175-179. 6. 田广文, 李鹏飞, 杜丽华,等. 柚皮中抑菌物提取工艺优化研究[J]. 安徽农业科学, 2015, 000(005):259-262,265. 7. 张红梅, 李国, 宋龙, et al. 贵州和浙江产吴茱萸指纹图谱分析及含量测定[J]. 中国实验方剂学杂志, 2014, 20(017):69-73. 8. 邵金华, 董加宝, 陈丽. 香柚籽中柠檬苦素的提取及纯化[J]. 食品与发酵工业, 2012(11):189-192. 9. 李一兵 龚桂芝 彭祝春 王艳杰 王炯 洪棋斌.不同甜橙品种果汁中柠檬苦素含量的变化[J].食品与发酵工业 2017 43(02):201-205. 10. 郁萌, 刘春泉, 牛丽影,等. 脱苦处理对枸橼汁品质的影响[J]. 江苏农业科学, 2014, 42(002):211-214. 11. 张珊,黄雪松.高效液相色谱法同时测定柚子中的4种黄酮苷和柠檬苦素[J].食品与机械,2021,37(03):58-63. 12. 周建新,沈硕,杜茂波,李玉洁,孙奕,何爱萍,姚瑶,王明硕,刘淑芝,尹永芹.基于UPLC-Q-TOF-MS技术和整合药理学方法探索吴茱萸经皮成分及其治疗腹泻的分子机制[J].中国实验方剂学杂志,2021,27(07):112-120. 13. Zhang, Yining, et al. "Development and validation of a sensitive LC–MS/MS assay for quantification of bruceine D in rat plasma." Biomedical Chromatography 30.11 (2016): 1873-1876.https://doi.org/10.1002/bmc.3724 14. [IF=4.411] Jun Zhang et al."Effects of Postharvest Time, Heat Treatment, pH and Filtration on the Limonin Content in Newhall Navel Orange (Citrus sinensis Osbeck cv. Newhall) Juice."Molecules. 2018 Oct;23(10):2691 15. [IF=1.902] Yining Zhang et al."Development and validation of a sensitive LC–MS/MS assay for quantification of bruceine D in rat plasma."Biomed Chromatogr. 2016 Nov;30(11):1873-1876 16. [IF=4.411] Liuyi Yu et al."Systematic Detection and Identification of Bioactive Ingredients from Citrus aurantium L. var. amara Using HPLC-Q-TOF-MS Combined with a Screening Method."Molecules. 2020 Jan;25(2):357 17. [IF=4.268] Runyu Yang et al."Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1."Phytomedicine. 2020 Apr;69:153211 18. [IF=4.192] Runyu Yang et al."Limonin Attenuates LPS-Induced Hepatotoxicity by Inhibiting Pyroptosis via NLRP3/Gasdermin D Signaling Pathway."J Agr Food Chem. 2021;69(3):982–991 19. [IF=3.943] Changqin Song et al."Limonin ameliorates dextran sulfate sodium-induced chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-κB signaling."Int Immunopharmacol. 2021 Jan;90:107161 20. [IF=3.463] Yun Liu et al."Structural diversity and distribution of limonoids in pummelo (Citrus grandis) fruit revealed by comprehensive UHPLC-MS/MS analysis."Sci Hortic-Amsterdam. 2021 May;282:109996 21. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 22. [IF=2.408] Wei Ling et al."Evaluation of Pomelo Seed Extracts as Natural Antioxidant, Antibacterial, Herbicidal Agents, and Their Functional Components."Chemistry & Biodiversity. 2021 Oct 27 23. [IF=4.556] Jingyi Zhang et al.Variations of the chemical composition of Citrus sinensis Osbeck cv. Newhall fruit in relation to the symptom severity of Huanglongbing.J Food Compos Anal. 2021 Nov;:104269 24. [IF=5.81] Yunjia Li et al."Limonin Alleviates Non-alcoholic Fatty Liver Disease by Reducing Lipid Accumulation, Suppressing Inflammation and Oxidative Stress."Front Pharmacol. 2021; 12: 801730 |
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